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IPACBIS SIGNED

Identifying preclinical Alzheimer´s disease in the community using a panel of biomarkers among individuals with Subjective Memory Complaints

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 IPACBIS project word cloud

Explore the words cloud of the IPACBIS project. It provides you a very rough idea of what is the project "IPACBIS" about.

economical    independent    complaints    academic    positron    tau    impairment    classified    anxiety    sensitive    lack    training    subgroup    baseline    fellowship    200    tomography    connections    clinical    preserved    biomarkers    united    career    experiencing    tests    organization    neuropsychological    cure    international    optical    countries    imaging    plasma    communication    benefit    publication    risk    techniques    receive    ad    therapy    symptoms    prevention    tenure    stages    cognition    back    trials    record    aged    population    track    healthy    acute    neuropathology    lumbar    host    sleep    coherence    decline    join    chances    researcher    florbetaben    memory    collaborative    msca    stay    modifying    specialized    oacute    elderly    preclinical    underlying    subjective    emission    dementia    brains    cognitive    follow    disease    epidemic    start    socio    initial    individuals    biomarker    mainly    puncture    2y    detected    onset    small    positive    drugs    alzheimer    depression    ace    percentage    followed    tested    smc    barcelona    therapies    interestingly    plans    fundaci   

Project "IPACBIS" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO ACE 

Organization address
address: MARQUES DE SENTMENAT 57
city: BARCELONA
postcode: 8014
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO ACE ES (BARCELONA) coordinator 158˙121.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

The dementia epidemic is a growing socio-economical problem in developed countries, including Europe, mainly due to aged population. Alzheimer´s disease (AD), the leading cause of dementia, has currently no prevention or cure. Identifying AD at early stages will likely improve the chances of developing an effective therapy. AD-related changes can be detected in brains of healthy individuals many years before the onset of cognitive decline using biomarkers. Testing all elderly healthy individuals would not be cost-effective, but interestingly many of them experience subjective memory complaints (SMC) but show preserved cognition when tested. Although conditions such as drugs, depression, anxiety or lack of sleep may be the underlying cause of SMC, a small percentage of individuals with SMC are experiencing the very initial symptoms of AD. The aim of this proposal is to identify which subgroup of individuals with SMC is at risk of developing AD dementia in the future. 200 individuals with SMC will be followed-up for 2y and tested with positron emission tomography with Florbetaben, plasma, lumbar puncture, optical coherence tomography and very sensitive neuropsychological tests at the Fundació ACE in Barcelona. Those finally classified as preclinical AD due to positive biomarkers at baseline and cognitive impairment at follow-up will be offered to join clinical trials for disease-modifying therapies against AD. The MSCA fellowship will allow the researcher to establish an independent career back in Europe after a stay in the United States, start academic tenure-track, improve her publication record, and receive specialized training in novel biomarker techniques and the preclinical phase of AD. The host organization will benefit from the researcher´s knowledge in tau imaging and neuropathology and her international connections to establish new collaborative projects. Plans for communication, exploitation and dissemination of the results will be established.

 Publications

year authors and title journal last update
List of publications.
2020 Marta Marquié, Sergi Valero, Miguel Castilla-Marti, Joan Martínez, Octavio Rodríguez-Gómez, Ángela Sanabria, Juan Pablo Tartari, Gemma C. Monté-Rubio, Oscar Sotolongo-Grau, Montserrat Alegret, Alba Pérez-Cordón, Natalia Roberto, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Isabel Hernández, Maitee Rosende-Roca, Ana Mauleón, Liliana Vargas, Carla Abdelnour, Silvia Gil, Ester Esteb
Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-020-00602-9
Alzheimer\'s Research & Therapy 12/1 2020-04-15
2019 Marta Marquié, Miguel Castilla-Martí, Sergi Valero, Joan Martínez, Domingo Sánchez, Isabel Hernández, Maitée Rosende-Roca, Liliana Vargas, Ana Mauleón, Octavio Rodríguez-Gómez, Carla Abdelnour, Silvia Gil, Miguel A. Santos-Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Ángela Sanabria, Natalia Roberto, Sonia Moreno-Grau, Itziar de Rojas, Rafael Simó, Andree
Visual impairment in aging and cognitive decline: experience in a Memory Clinic
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45055-9
Scientific Reports 9/1 2019-08-05

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The information about "IPACBIS" are provided by the European Opendata Portal: CORDIS opendata.

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