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Identifying preclinical Alzheimer´s disease in the community using a panel of biomarkers among individuals with Subjective Memory Complaints

Total Cost €


EC-Contrib. €






 IPACBIS project word cloud

Explore the words cloud of the IPACBIS project. It provides you a very rough idea of what is the project "IPACBIS" about.

msca    alzheimer    back    aged    population    acute    baseline    interestingly    epidemic    communication    disease    impairment    detected    imaging    cognitive    positive    tested    plans    mainly    positron    track    tau    complaints    countries    cure    lumbar    chances    classified    barcelona    trials    subjective    ace    sensitive    fundaci    international    emission    preserved    percentage    experiencing    healthy    onset    collaborative    preclinical    ad    fellowship    benefit    underlying    training    stages    therapy    tenure    cognition    career    elderly    tomography    smc    puncture    individuals    specialized    receive    prevention    2y    optical    symptoms    united    follow    initial    risk    sleep    anxiety    lack    techniques    coherence    researcher    therapies    decline    neuropsychological    biomarker    oacute    record    modifying    florbetaben    small    start    subgroup    publication    socio    drugs    memory    brains    followed    dementia    200    academic    organization    connections    economical    clinical    neuropathology    tests    join    independent    biomarkers    host    plasma    depression    stay   

Project "IPACBIS" data sheet

The following table provides information about the project.


Organization address
postcode: 8014
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO ACE ES (BARCELONA) coordinator 158˙121.00


 Project objective

The dementia epidemic is a growing socio-economical problem in developed countries, including Europe, mainly due to aged population. Alzheimer´s disease (AD), the leading cause of dementia, has currently no prevention or cure. Identifying AD at early stages will likely improve the chances of developing an effective therapy. AD-related changes can be detected in brains of healthy individuals many years before the onset of cognitive decline using biomarkers. Testing all elderly healthy individuals would not be cost-effective, but interestingly many of them experience subjective memory complaints (SMC) but show preserved cognition when tested. Although conditions such as drugs, depression, anxiety or lack of sleep may be the underlying cause of SMC, a small percentage of individuals with SMC are experiencing the very initial symptoms of AD. The aim of this proposal is to identify which subgroup of individuals with SMC is at risk of developing AD dementia in the future. 200 individuals with SMC will be followed-up for 2y and tested with positron emission tomography with Florbetaben, plasma, lumbar puncture, optical coherence tomography and very sensitive neuropsychological tests at the Fundació ACE in Barcelona. Those finally classified as preclinical AD due to positive biomarkers at baseline and cognitive impairment at follow-up will be offered to join clinical trials for disease-modifying therapies against AD. The MSCA fellowship will allow the researcher to establish an independent career back in Europe after a stay in the United States, start academic tenure-track, improve her publication record, and receive specialized training in novel biomarker techniques and the preclinical phase of AD. The host organization will benefit from the researcher´s knowledge in tau imaging and neuropathology and her international connections to establish new collaborative projects. Plans for communication, exploitation and dissemination of the results will be established.


year authors and title journal last update
List of publications.
2020 Marta Marquié, Sergi Valero, Miguel Castilla-Marti, Joan Martínez, Octavio Rodríguez-Gómez, Ángela Sanabria, Juan Pablo Tartari, Gemma C. Monté-Rubio, Oscar Sotolongo-Grau, Montserrat Alegret, Alba Pérez-Cordón, Natalia Roberto, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Isabel Hernández, Maitee Rosende-Roca, Ana Mauleón, Liliana Vargas, Carla Abdelnour, Silvia Gil, Ester Esteb
Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-020-00602-9
Alzheimer\'s Research & Therapy 12/1 2020-04-15
2019 Marta Marquié, Miguel Castilla-Martí, Sergi Valero, Joan Martínez, Domingo Sánchez, Isabel Hernández, Maitée Rosende-Roca, Liliana Vargas, Ana Mauleón, Octavio Rodríguez-Gómez, Carla Abdelnour, Silvia Gil, Miguel A. Santos-Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Ángela Sanabria, Natalia Roberto, Sonia Moreno-Grau, Itziar de Rojas, Rafael Simó, Andree
Visual impairment in aging and cognitive decline: experience in a Memory Clinic
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45055-9
Scientific Reports 9/1 2019-08-05

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The information about "IPACBIS" are provided by the European Opendata Portal: CORDIS opendata.

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