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IPACBIS SIGNED

Identifying preclinical Alzheimer´s disease in the community using a panel of biomarkers among individuals with Subjective Memory Complaints

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IPACBIS project word cloud

Explore the words cloud of the IPACBIS project. It provides you a very rough idea of what is the project "IPACBIS" about.

countries    join    trials    publication    united    stay    prevention    biomarkers    follow    sensitive    classified    academic    dementia    complaints    socio    chances    followed    researcher    cure    anxiety    detected    cognition    subjective    therapies    collaborative    experiencing    receive    healthy    clinical    mainly    impairment    ace    tests    drugs    underlying    sleep    therapy    independent    aged    disease    techniques    oacute    specialized    subgroup    percentage    msca    communication    neuropsychological    biomarker    plans    fellowship    ad    training    elderly    neuropathology    positron    cognitive    modifying    tenure    baseline    economical    plasma    memory    smc    2y    imaging    fundaci    onset    benefit    brains    decline    tomography    population    interestingly    symptoms    track    tested    risk    lack    international    optical    start    preserved    emission    organization    lumbar    coherence    depression    alzheimer    career    connections    epidemic    back    preclinical    florbetaben    host    tau    individuals    acute    stages    puncture    barcelona    small    positive    200    initial    record   

Project "IPACBIS" data sheet

The following table provides information about the project.

Coordinator		 FUNDACIO ACE 

Organization address
address: MARQUES DE SENTMENAT 57
city: BARCELONA
postcode: 8014
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO ACE ES (BARCELONA) coordinator 158˙121.00

Map

 Project objective

The dementia epidemic is a growing socio-economical problem in developed countries, including Europe, mainly due to aged population. Alzheimer´s disease (AD), the leading cause of dementia, has currently no prevention or cure. Identifying AD at early stages will likely improve the chances of developing an effective therapy. AD-related changes can be detected in brains of healthy individuals many years before the onset of cognitive decline using biomarkers. Testing all elderly healthy individuals would not be cost-effective, but interestingly many of them experience subjective memory complaints (SMC) but show preserved cognition when tested. Although conditions such as drugs, depression, anxiety or lack of sleep may be the underlying cause of SMC, a small percentage of individuals with SMC are experiencing the very initial symptoms of AD. The aim of this proposal is to identify which subgroup of individuals with SMC is at risk of developing AD dementia in the future. 200 individuals with SMC will be followed-up for 2y and tested with positron emission tomography with Florbetaben, plasma, lumbar puncture, optical coherence tomography and very sensitive neuropsychological tests at the Fundació ACE in Barcelona. Those finally classified as preclinical AD due to positive biomarkers at baseline and cognitive impairment at follow-up will be offered to join clinical trials for disease-modifying therapies against AD. The MSCA fellowship will allow the researcher to establish an independent career back in Europe after a stay in the United States, start academic tenure-track, improve her publication record, and receive specialized training in novel biomarker techniques and the preclinical phase of AD. The host organization will benefit from the researcher´s knowledge in tau imaging and neuropathology and her international connections to establish new collaborative projects. Plans for communication, exploitation and dissemination of the results will be established.

 Publications

year authors and title journal last update
List of publications.
2020 Marta Marquié, Sergi Valero, Miguel Castilla-Marti, Joan Martínez, Octavio Rodríguez-Gómez, Ángela Sanabria, Juan Pablo Tartari, Gemma C. Monté-Rubio, Oscar Sotolongo-Grau, Montserrat Alegret, Alba Pérez-Cordón, Natalia Roberto, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Isabel Hernández, Maitee Rosende-Roca, Ana Mauleón, Liliana Vargas, Carla Abdelnour, Silvia Gil, Ester Esteb
Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-020-00602-9 		Alzheimer\'s Research & Therapy 12/1 2020-04-15
2019 Marta Marquié, Miguel Castilla-Martí, Sergi Valero, Joan Martínez, Domingo Sánchez, Isabel Hernández, Maitée Rosende-Roca, Liliana Vargas, Ana Mauleón, Octavio Rodríguez-Gómez, Carla Abdelnour, Silvia Gil, Miguel A. Santos-Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Ángela Sanabria, Natalia Roberto, Sonia Moreno-Grau, Itziar de Rojas, Rafael Simó, Andree
Visual impairment in aging and cognitive decline: experience in a Memory Clinic
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45055-9 		Scientific Reports 9/1 2019-08-05

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The information about "IPACBIS" are provided by the European Opendata Portal: CORDIS opendata.

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