Explore the words cloud of the IPACBIS project. It provides you a very rough idea of what is the project "IPACBIS" about.
The following table provides information about the project.
|Coordinator Country||Spain [ES]|
|Total cost||158˙121 €|
|EC max contribution||158˙121 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-03-01 to 2020-02-29|
Take a look of project's partnership.
The dementia epidemic is a growing socio-economical problem in developed countries, including Europe, mainly due to aged population. Alzheimer´s disease (AD), the leading cause of dementia, has currently no prevention or cure. Identifying AD at early stages will likely improve the chances of developing an effective therapy. AD-related changes can be detected in brains of healthy individuals many years before the onset of cognitive decline using biomarkers. Testing all elderly healthy individuals would not be cost-effective, but interestingly many of them experience subjective memory complaints (SMC) but show preserved cognition when tested. Although conditions such as drugs, depression, anxiety or lack of sleep may be the underlying cause of SMC, a small percentage of individuals with SMC are experiencing the very initial symptoms of AD. The aim of this proposal is to identify which subgroup of individuals with SMC is at risk of developing AD dementia in the future. 200 individuals with SMC will be followed-up for 2y and tested with positron emission tomography with Florbetaben, plasma, lumbar puncture, optical coherence tomography and very sensitive neuropsychological tests at the Fundació ACE in Barcelona. Those finally classified as preclinical AD due to positive biomarkers at baseline and cognitive impairment at follow-up will be offered to join clinical trials for disease-modifying therapies against AD. The MSCA fellowship will allow the researcher to establish an independent career back in Europe after a stay in the United States, start academic tenure-track, improve her publication record, and receive specialized training in novel biomarker techniques and the preclinical phase of AD. The host organization will benefit from the researcher´s knowledge in tau imaging and neuropathology and her international connections to establish new collaborative projects. Plans for communication, exploitation and dissemination of the results will be established.
|year||authors and title||journal||last update|
Marta MarquiÃ©, Sergi Valero, Miguel Castilla-Marti, Joan MartÃnez, Octavio RodrÃguez-GÃ³mez, Ãngela Sanabria, Juan Pablo Tartari, Gemma C. MontÃ©-Rubio, Oscar Sotolongo-Grau, Montserrat Alegret, Alba PÃ©rez-CordÃ³n, Natalia Roberto, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Isabel HernÃ¡ndez, Maitee Rosende-Roca, Ana MauleÃ³n, Liliana Vargas, Carla Abdelnour, Silvia Gil, Ester Esteb
Association between retinal thickness and Î²-amyloid brain accumulation in individuals with subjective cognitive decline: FundaciÃ³ ACE Healthy Brain Initiative
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-020-00602-9
|Alzheimer\'s Research & Therapy 12/1||2020-04-15|
Marta MarquiÃ©, Miguel Castilla-MartÃ, Sergi Valero, Joan MartÃnez, Domingo SÃ¡nchez, Isabel HernÃ¡ndez, MaitÃ©e Rosende-Roca, Liliana Vargas, Ana MauleÃ³n, Octavio RodrÃguez-GÃ³mez, Carla Abdelnour, Silvia Gil, Miguel A. Santos-Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Alba PÃ©rez-CordÃ³n, Ãngela Sanabria, Natalia Roberto, Sonia Moreno-Grau, Itziar de Rojas, Rafael SimÃ³, Andree
Visual impairment in aging and cognitive decline: experience in a Memory Clinic
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-45055-9
|Scientific Reports 9/1||2019-08-05|
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