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PHANTOM SIGNED

Phenotypic screening the host antimicrobial responses towards the eradication of Mycobacterium tubercuosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 PHANTOM project word cloud

Explore the words cloud of the PHANTOM project. It provides you a very rough idea of what is the project "PHANTOM" about.

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Project "PHANTOM" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 170˙121.00

Map

 Project objective

The co-evolution between hosts and their parasites is one of the most fascinating examples of evolutionary adaptation. However, there is a paucity of information on how the human immune system co-adapts to the parasites phenotypic plasticity, and how it dynamically rearranges its molecular phenotypes aiming to counteract the pathogenic threats. Hence, many therapies for the treatment of intracellular bacteria-related infection (e.g., tuberculosis) are currently obsolete, especially because of the rise in drug resistance. In this framework, the main goal of my proposal is to decipher the unexplored phenotype ‘bar-codes’ of host-pathogen interaction, in order to reversely engineer a drug delivery platform aiming to target infected cells only, and to eradicate intracellular parasites. The final aim will be that of eradicating the severe intracellular pathogens Mycobacterium tuberculosis (Mtb), as it is the major cause of mortality related to bacterial infection worldwide. According to the World Health Organisation, in fact, approximately one-third of the world’s population is asymptomatically affected by TB, with about 9 million new cases of per year (of which 11% are children under 15 years), and 1.4 million of deaths. Despite decades of control programs, TB is still second only to HIV as the greatest killer worldwide due to a single infectious agent (the average killing rate of TB is 3 people per minute). This project will thus explore the molecular bases of Mtb-host interaction. These investigations will be used to engineer 'super-selective' polymeric nanoparticles targeting infected cells only (thus avoiding side effects), and to eradicate intracellular parasite. This will be done while adopting strategies that counteract the development drug resistance. Hence, this project will avoid falling in what has been called as the potential new ‘Dark Middle Age” era of lack of antibiotics.

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The information about "PHANTOM" are provided by the European Opendata Portal: CORDIS opendata.

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