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PHANTOM SIGNED

Phenotypic screening the host antimicrobial responses towards the eradication of Mycobacterium tubercuosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PHANTOM project word cloud

Explore the words cloud of the PHANTOM project. It provides you a very rough idea of what is the project "PHANTOM" about.

counteract    organisation    falling    avoiding    evolution    age    human    15    reversely    codes    agent    host    11    phenotypic    infectious    drug    hence    parasites    polymeric    worldwide    plasticity    fascinating    approximately    molecular    eradicating    decipher    middle    mortality    despite    final    platform    tb    bacterial    deaths    threats    world    pathogens    examples    therapies    phenotypes    pathogenic    severe    population    greatest    co    intracellular    bacteria    dark    resistance    people    adapts    infection    strategies    programs    rate    era    cells    lack    tuberculosis    health    selective    rearranges    immune    engineer    decades    obsolete    dynamically    paucity    killing    nanoparticles    mtb    antibiotics    infected    hiv    asymptomatically    bar    mycobacterium    pathogen    minute    adopting    investigations    hosts    children    eradicate    interaction    killer    framework    single    phenotype    parasite    super    bases    fact    explore    evolutionary    million    treatment    unexplored   

Project "PHANTOM" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 170˙121.00

Map

 Project objective

The co-evolution between hosts and their parasites is one of the most fascinating examples of evolutionary adaptation. However, there is a paucity of information on how the human immune system co-adapts to the parasites phenotypic plasticity, and how it dynamically rearranges its molecular phenotypes aiming to counteract the pathogenic threats. Hence, many therapies for the treatment of intracellular bacteria-related infection (e.g., tuberculosis) are currently obsolete, especially because of the rise in drug resistance. In this framework, the main goal of my proposal is to decipher the unexplored phenotype ‘bar-codes’ of host-pathogen interaction, in order to reversely engineer a drug delivery platform aiming to target infected cells only, and to eradicate intracellular parasites. The final aim will be that of eradicating the severe intracellular pathogens Mycobacterium tuberculosis (Mtb), as it is the major cause of mortality related to bacterial infection worldwide. According to the World Health Organisation, in fact, approximately one-third of the world’s population is asymptomatically affected by TB, with about 9 million new cases of per year (of which 11% are children under 15 years), and 1.4 million of deaths. Despite decades of control programs, TB is still second only to HIV as the greatest killer worldwide due to a single infectious agent (the average killing rate of TB is 3 people per minute). This project will thus explore the molecular bases of Mtb-host interaction. These investigations will be used to engineer 'super-selective' polymeric nanoparticles targeting infected cells only (thus avoiding side effects), and to eradicate intracellular parasite. This will be done while adopting strategies that counteract the development drug resistance. Hence, this project will avoid falling in what has been called as the potential new ‘Dark Middle Age” era of lack of antibiotics.

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The information about "PHANTOM" are provided by the European Opendata Portal: CORDIS opendata.

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