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PHANTOM SIGNED

Phenotypic screening the host antimicrobial responses towards the eradication of Mycobacterium tubercuosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 PHANTOM project word cloud

Explore the words cloud of the PHANTOM project. It provides you a very rough idea of what is the project "PHANTOM" about.

single    hiv    investigations    co    falling    threats    agent    drug    infection    tuberculosis    eradicating    adopting    plasticity    counteract    health    dynamically    asymptomatically    eradicate    era    selective    deaths    intracellular    host    avoiding    decades    bacteria    rearranges    organisation    polymeric    despite    middle    molecular    engineer    parasite    people    parasites    fact    bacterial    explore    human    11    pathogens    minute    approximately    obsolete    fascinating    phenotypes    adapts    infectious    hence    infected    dark    strategies    examples    severe    pathogen    antibiotics    age    mtb    decipher    killer    framework    15    evolutionary    greatest    unexplored    reversely    mycobacterium    killing    codes    super    worldwide    final    bases    cells    interaction    evolution    world    mortality    lack    pathogenic    phenotypic    hosts    therapies    paucity    phenotype    treatment    children    platform    tb    immune    population    resistance    nanoparticles    programs    bar    rate    million   

Project "PHANTOM" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA 

Organization address
address: CARRER BALDIRI REIXAC PLANTA 2A 10-12
city: BARCELONA
postcode: 8028
website: http://www.ibecbarcelona.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA ES (BARCELONA) coordinator 170˙121.00

Map

 Project objective

The co-evolution between hosts and their parasites is one of the most fascinating examples of evolutionary adaptation. However, there is a paucity of information on how the human immune system co-adapts to the parasites phenotypic plasticity, and how it dynamically rearranges its molecular phenotypes aiming to counteract the pathogenic threats. Hence, many therapies for the treatment of intracellular bacteria-related infection (e.g., tuberculosis) are currently obsolete, especially because of the rise in drug resistance. In this framework, the main goal of my proposal is to decipher the unexplored phenotype ‘bar-codes’ of host-pathogen interaction, in order to reversely engineer a drug delivery platform aiming to target infected cells only, and to eradicate intracellular parasites. The final aim will be that of eradicating the severe intracellular pathogens Mycobacterium tuberculosis (Mtb), as it is the major cause of mortality related to bacterial infection worldwide. According to the World Health Organisation, in fact, approximately one-third of the world’s population is asymptomatically affected by TB, with about 9 million new cases of per year (of which 11% are children under 15 years), and 1.4 million of deaths. Despite decades of control programs, TB is still second only to HIV as the greatest killer worldwide due to a single infectious agent (the average killing rate of TB is 3 people per minute). This project will thus explore the molecular bases of Mtb-host interaction. These investigations will be used to engineer 'super-selective' polymeric nanoparticles targeting infected cells only (thus avoiding side effects), and to eradicate intracellular parasite. This will be done while adopting strategies that counteract the development drug resistance. Hence, this project will avoid falling in what has been called as the potential new ‘Dark Middle Age” era of lack of antibiotics.

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The information about "PHANTOM" are provided by the European Opendata Portal: CORDIS opendata.

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