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SysOrganoid SIGNED

A systems biology approach to investigate cell fate switches in intestinal organoids

Total Cost €

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EC-Contrib. €

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Partnership

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 SysOrganoid project word cloud

Explore the words cloud of the SysOrganoid project. It provides you a very rough idea of what is the project "SysOrganoid" about.

medicine    miniguts    regulatory    biology    small    first    orchestrate    transcription    cell    perturbations    manner    powerful    generation    gene    obtain    methylated    perfect    time    combination    intricate    enriched    chromatin    contain    profound    modifications    readers    revealed    cultures    plasticity    cells    paradigm    functionally    epithelium    emerged    epigenetics    molecule    epigenetic    cellular    basic    post    integrate    spectrometry    dna    area    translational    scientific    maintenance    understand    expression    proteomics    mechanisms    fate    complementary    programs    regenerative    organoids    differentiation    view    integral    cultured    big    implications    embryonic    remarkable    networks    histones    dynamic    stem    vitro    organoid    proteins    intestinal    de    cancer    shown    adult    hydroxy    omics    mouse    interact    homeostasis    provides    pioneering    molecular    technologies    sequencing    mass    integrative    types    opportunity    organ   

Project "SysOrganoid" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙000˙000.00

Map

 Project objective

Mass spectrometry-based proteomics and next generation DNA sequencing emerged as two powerful and complementary technologies in biology. I was the first to integrate these technologies in the area of epigenetics to identify and functionally characterize proteins that interact with post-translational modifications on histones and (hydroxy)methylated DNA (so-called chromatin ‘readers’). My pioneering work revealed that an intricate networks of transcription factors, chromatin modifications and chromatin readers orchestrate dynamic gene expression programs during embryonic stem cell differentiation. The next big challenge is to understand the molecular mechanisms, which help to control maintenance and differentiation of adult stem cells as an integral part of an organ. Intestinal organoid cultures recently emerged as a paradigm to study adult stem cell maintenance and differentiation. These ‘miniguts’ can be cultured in vitro and contain all the different cell types that are present in the mouse small intestinal epithelium. Recently it was shown that small-molecule driven perturbations can be used to obtain organoids which are strongly enriched for specific intestinal cell types. This system thus provides a perfect opportunity to study for the first time and in a controlled manner, adult stem cell maintenance and (de)differentiation. Using small molecule-driven perturbations and a unique combination of ‘omics’ technologies, which are embedded in my department, I will provide a systems-wide view of the molecular (epigenetic) mechanisms that orchestrate cell fate changes in intestinal organoids. This integrative approach will identify the major regulatory networks that define the remarkable cellular plasticity of the mouse small intestinal epithelium. Beyond this basic scientific goal, our work will also have profound implications for cancer research and regenerative medicine, both of which are characterized by changes in adult stem cell homeostasis.

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The information about "SYSORGANOID" are provided by the European Opendata Portal: CORDIS opendata.

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