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SysOrganoid SIGNED

A systems biology approach to investigate cell fate switches in intestinal organoids

Total Cost €

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EC-Contrib. €

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Partnership

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 SysOrganoid project word cloud

Explore the words cloud of the SysOrganoid project. It provides you a very rough idea of what is the project "SysOrganoid" about.

cell    programs    molecular    profound    perturbations    gene    time    differentiation    biology    cells    view    plasticity    dna    integrative    small    epigenetics    transcription    basic    first    maintenance    epithelium    provides    fate    histones    enriched    perfect    intricate    big    organoids    proteomics    mechanisms    translational    spectrometry    pioneering    integral    mouse    scientific    medicine    post    complementary    omics    understand    readers    epigenetic    de    opportunity    cultured    integrate    shown    cancer    networks    stem    molecule    emerged    dynamic    chromatin    methylated    obtain    cultures    area    mass    embryonic    paradigm    intestinal    proteins    interact    cellular    remarkable    revealed    contain    vitro    technologies    implications    regulatory    types    combination    homeostasis    orchestrate    manner    expression    sequencing    organ    adult    regenerative    modifications    hydroxy    powerful    miniguts    generation    functionally    organoid   

Project "SysOrganoid" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙000˙000.00

Map

 Project objective

Mass spectrometry-based proteomics and next generation DNA sequencing emerged as two powerful and complementary technologies in biology. I was the first to integrate these technologies in the area of epigenetics to identify and functionally characterize proteins that interact with post-translational modifications on histones and (hydroxy)methylated DNA (so-called chromatin ‘readers’). My pioneering work revealed that an intricate networks of transcription factors, chromatin modifications and chromatin readers orchestrate dynamic gene expression programs during embryonic stem cell differentiation. The next big challenge is to understand the molecular mechanisms, which help to control maintenance and differentiation of adult stem cells as an integral part of an organ. Intestinal organoid cultures recently emerged as a paradigm to study adult stem cell maintenance and differentiation. These ‘miniguts’ can be cultured in vitro and contain all the different cell types that are present in the mouse small intestinal epithelium. Recently it was shown that small-molecule driven perturbations can be used to obtain organoids which are strongly enriched for specific intestinal cell types. This system thus provides a perfect opportunity to study for the first time and in a controlled manner, adult stem cell maintenance and (de)differentiation. Using small molecule-driven perturbations and a unique combination of ‘omics’ technologies, which are embedded in my department, I will provide a systems-wide view of the molecular (epigenetic) mechanisms that orchestrate cell fate changes in intestinal organoids. This integrative approach will identify the major regulatory networks that define the remarkable cellular plasticity of the mouse small intestinal epithelium. Beyond this basic scientific goal, our work will also have profound implications for cancer research and regenerative medicine, both of which are characterized by changes in adult stem cell homeostasis.

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The information about "SYSORGANOID" are provided by the European Opendata Portal: CORDIS opendata.

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