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SysOrganoid SIGNED

A systems biology approach to investigate cell fate switches in intestinal organoids

Total Cost €

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EC-Contrib. €

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Partnership

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 SysOrganoid project word cloud

Explore the words cloud of the SysOrganoid project. It provides you a very rough idea of what is the project "SysOrganoid" about.

mass    organ    expression    shown    understand    adult    mouse    integral    integrative    complementary    differentiation    manner    big    time    pioneering    perfect    epithelium    types    molecule    generation    biology    cellular    basic    programs    molecular    proteomics    cultures    omics    fate    intestinal    functionally    provides    epigenetics    post    perturbations    networks    miniguts    implications    vitro    enriched    profound    integrate    medicine    cancer    orchestrate    revealed    technologies    dynamic    sequencing    dna    cells    interact    emerged    view    proteins    regenerative    first    de    scientific    stem    combination    translational    transcription    small    intricate    methylated    organoid    readers    cultured    hydroxy    cell    homeostasis    plasticity    modifications    paradigm    spectrometry    opportunity    embryonic    gene    contain    maintenance    remarkable    powerful    histones    organoids    chromatin    obtain    mechanisms    area    epigenetic    regulatory   

Project "SysOrganoid" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 2˙000˙000.00

Map

 Project objective

Mass spectrometry-based proteomics and next generation DNA sequencing emerged as two powerful and complementary technologies in biology. I was the first to integrate these technologies in the area of epigenetics to identify and functionally characterize proteins that interact with post-translational modifications on histones and (hydroxy)methylated DNA (so-called chromatin ‘readers’). My pioneering work revealed that an intricate networks of transcription factors, chromatin modifications and chromatin readers orchestrate dynamic gene expression programs during embryonic stem cell differentiation. The next big challenge is to understand the molecular mechanisms, which help to control maintenance and differentiation of adult stem cells as an integral part of an organ. Intestinal organoid cultures recently emerged as a paradigm to study adult stem cell maintenance and differentiation. These ‘miniguts’ can be cultured in vitro and contain all the different cell types that are present in the mouse small intestinal epithelium. Recently it was shown that small-molecule driven perturbations can be used to obtain organoids which are strongly enriched for specific intestinal cell types. This system thus provides a perfect opportunity to study for the first time and in a controlled manner, adult stem cell maintenance and (de)differentiation. Using small molecule-driven perturbations and a unique combination of ‘omics’ technologies, which are embedded in my department, I will provide a systems-wide view of the molecular (epigenetic) mechanisms that orchestrate cell fate changes in intestinal organoids. This integrative approach will identify the major regulatory networks that define the remarkable cellular plasticity of the mouse small intestinal epithelium. Beyond this basic scientific goal, our work will also have profound implications for cancer research and regenerative medicine, both of which are characterized by changes in adult stem cell homeostasis.

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The information about "SYSORGANOID" are provided by the European Opendata Portal: CORDIS opendata.

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