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rEnDOx SIGNED

REDOX SIGNALING AND METABOLIC STATES IN ANGIOGENESIS IN HEALTH AND DISEASE

Total Cost €

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EC-Contrib. €

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Partnership

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Project "rEnDOx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.massimosantorolab.com
 Total cost 1˙999˙827 €
 EC max contribution 1˙999˙827 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 1˙696˙074.00
2    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 303˙752.00

Map

 Project objective

Endothelial cells (ECs) exhibit a remarkable and unique plasticity in terms of redox biology and metabolism. They can quickly adapt to oxygen, nitric oxide and metabolic variations. Therefore, EC must be equipped with a selective and unique repertoire of redox and metabolic mechanisms, that play a crucial role to preserve redox balance, and adjust metabolic conditions in both normal and pathological angiogenesis. The identification of such redox signaling and metabolic pathways is crucial to the gaining of better insights in endothelial biology and dysfunction. More importantly, these insights could be used to establish innovative therapeutic approaches for the treatment of those conditions where aberrant or excessive angiogenesis is the underlying cause of the disease itself. However, the formation, actions, key molecular interactions, and physiological and pathological relevance of redox signals in ECs remain unclear. Here, by using cutting-edge real-time redox imaging platforms, and innovative molecular and genetic approaches in different in vivo animal models, we will (1) reveal the working of redox signaling in EC in health and disease, (2) shed light on the novel role for the mevalonate metabolic pathway in angiogenesis and (3) provide solid evidence, that manipulation of endothelial redox and metabolic state by genetic alteration of the redox rheostat UBIAD1, is a valuable strategy by which to block pathological angiogenesis in vivo. The ultimate objective is to open the way for the development of innovative (cancer) therapeutic strategies and complement the existing ones based on genetic or pharmacological manipulation of redox rheostats to balance oxidative or reductive stress in angiogenic processes. The success of this project is built upon our major expertise in the field of angiogenesis in small vertebrate animal models as well as on the collaborations with leading laboratories that are active in research on the pre-clinical stages for angiogenesis-rel

 Publications

year authors and title journal last update
List of publications.
2018 Roxana E. Oberkersch, Massimo M. Santoro
Role of amino acid metabolism in angiogenesis
published pages: , ISSN: 1537-1891, DOI: 10.1016/j.vph.2018.11.001
Vascular Pharmacology 2019-05-23
2018 E. Zulato, F. Ciccarese, V. Agnusdei, M. Pinazza, G. Nardo, E. Iorio, M. Curtarello, M. Silic-Benussi, E. Rossi, C. Venturoli, E. Panieri, M.M. Santoro, V. Di Paolo, L. Quintieri, V. Ciminale, S. Indraccolo
LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation
published pages: 479-490, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.09.019
Biochemical Pharmacology 156 2019-05-23
2018 Massimo Mattia Santoro
Fashioning blood vessels by ROS signalling and metabolism
published pages: 35-42, ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2017.08.002
Seminars in Cell & Developmental Biology 80 2019-03-18
2018 Dougall M. Norris, Massimo M. Santoro
Before the Pump
published pages: 2763-2764, ISSN: 1079-5642, DOI: 10.1161/atvbaha.118.311893
Arteriosclerosis, Thrombosis, and Vascular Biology 38/12 2019-03-18
2018 Sanjay Sinha, Massimo Mattia Santoro
New models to study vascular mural cell embryonic origin: implications in vascular diseases
published pages: 481-491, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy005
Cardiovascular Research 114/4 2019-03-18
2016 Raj Sewduth, Massimo M. Santoro
“Decoding” Angiogenesis: New Facets Controlling Endothelial Cell Behavior
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00306
Frontiers in Physiology 7 2019-03-18
2018 Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06406-8
Nature Communications 9/1 2019-03-18
2018 Katia Rupel, Luisa Zupin, Andrea Colliva, Anselmo Kamada, Augusto Poropat, Giulia Ottaviani, Margherita Gobbo, Lidia Fanfoni, Rossella Gratton, Massimo Santoro, Roberto Di Lenarda, Matteo Biasotto, Serena Zacchigna
Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo
published pages: 1-11, ISSN: 1942-0900, DOI: 10.1155/2018/6510159
Oxidative Medicine and Cellular Longevity 2018 2019-03-18
2018 Jacoba J. Louw, Ricardo Nunes Bastos, Xiaowen Chen, Céline Verdood, Anniek Corveleyn, Yaojuan Jia, Jeroen Breckpot, Marc Gewillig, Hilde Peeters, Massimo M. Santoro, Francis Barr, Koenraad Devriendt
Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings
published pages: e1007138, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007138
PLOS Genetics 14/1 2019-03-18
2016 E Panieri, M M Santoro
ROS homeostasis and metabolism: a dangerous liason in cancer cells
published pages: e2253, ISSN: 2041-4889, DOI: 10.1038/cddis.2016.105
Cell Death and Disease 7/6 2019-05-31
2017 Dafne Gays, Christopher Hess, Annalisa Camporeale, Ugo Ala, Paolo Provero, Christian Mosimann, Massimo M. Santoro
An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates
published pages: 464-478, ISSN: 0950-1991, DOI: 10.1242/dev.133926
Development 144/3 2019-05-31
2017 Emiliano Panieri, Massimo M. Santoro
Data on metabolic-dependent antioxidant response in the cardiovascular tissues of living zebrafish under stress conditions
published pages: 427-432, ISSN: 2352-3409, DOI: 10.1016/j.dib.2017.04.034
Data in Brief 12 2019-05-31
2016 Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. Böttcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini, Donatella Valdembri
PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
published pages: 13546, ISSN: 2041-1723, DOI: 10.1038/ncomms13546
Nature Communications 7 2019-05-31
2017 Xiaowen Chen, Dafne Gays, Carlo Milia, Massimo M. Santoro
Cilia Control Vascular Mural Cell Recruitment in Vertebrates
published pages: 1033-1047, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.12.044
Cell Reports 18/4 2019-05-31
2016 Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg, Ralf H. Adams
Blood flow controls bone vascular function and osteogenesis
published pages: 13601, ISSN: 2041-1723, DOI: 10.1038/ncomms13601
Nature Communications 7 2019-05-31
2017 Emiliano Panieri, Carlo Millia, Massimo M. Santoro
Real-time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues
published pages: , ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2017.02.022
Free Radical Biology and Medicine 2019-05-31

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