Opendata, web and dolomites

Striking streaks SIGNED

Invariant Natural Killer T-cells in atherogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Striking streaks project word cloud

Explore the words cloud of the Striking streaks project. It provides you a very rough idea of what is the project "Striking streaks" about.

many    presented    expert    natural    elusive    atherogenesis    first    immune    followed    plaque    explore    mass    lipid    labeling    cerundolo    inkt    maturation    cell    monaco    biotin    structural    mouse    setting    cytometry    underlies    antigens    immunology    secondly    restriction    therapeutic    function    invariant    survivors    resident    renowned    later    phenotype    life    exact    model    site    cells    excellent    physician    am    spectrometry    university    identification    molecules    glycolipid    pivotal    human    antigen    lifelong    cd1d    sortase    functional    interaction    enzymes    oxford    atheroma    killer    fight    passionate    disorders    atherosclerosis    etiology    vivo    inspired    cardiovascular    inkts    chronic    isolation    treatment    laboratory    manipulate    complexes    scientist    prof    sortagging    struggle    unravel    combines    bacterial    plan    childhood    ex    cd1d1    kennedy    cleavage    employs    translational    disease    innovative   

Project "Striking streaks" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

Map

 Project objective

Many survivors of childhood chronic disease struggle with early atherosclerosis later in life. As a physician-scientist I am inspired by their lifelong fight, and my research focuses on the etiology and treatment of early atherosclerosis. Here, I aim to unravel the role of invariant Natural Killer T-cells (iNKTs) in atherogenesis. iNKTs are unique for their restriction to lipid antigens presented on CD1d molecules, which underlies their pivotal role in lipid-driven disorders such as atherosclerosis. The exact role of iNKTs however remains elusive, as long as the involved plaque-associated lipid antigens have not been identified. Therefore, I developed CD1d-sortagging as a novel and innovative approach for lipid antigen identification. CD1d-sortagging employs bacterial sortase enzymes for site-specific cleavage and biotin labeling of CD1d-lipid antigen complexes, followed by isolation and mass spectrometry identification of the lipid antigens. At the Cardiovascular Immunology laboratory of Prof. Monaco at the Kennedy Institute of Oxford University, in a unique collaboration with renowned iNKT-glycolipid expert Prof. Cerundolo, I first aim to identify plaque-associated lipid antigens. CD1d-sortagging will be applied ex vivo in a human atheroma model, and in vivo in a CD1d1-sortagging mouse model for atherosclerosis. Upon identification, I secondly aim to unravel the impact of plaque-associated lipid antigens on iNKT cell phenotype and function using Mass Cytometry of plaque-resident immune cells and study the structural and functional aspects of plaque lipid-iNKT cell interaction. Finally, I will explore the therapeutic potential of plaque-associated lipid antigens to manipulate iNKT cell function and atherogenesis in a mouse model for atherosclerosis. Taken together, this proposal combines an innovative approach and excellent research setting with translational impact, an effective work plan, and maturation of a passionate physician-scientist.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STRIKING STREAKS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "STRIKING STREAKS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MIGPSC (2018)

Shaping the European Migration Policy: the role of the security industry

Read More  

MBL-Fermions (2020)

Probing many-body localization dynamics using ultracold fermions in an optical lattice

Read More  

STRESS-Mums (2019)

Study on TRansition and Exclusion in Society of Single-Mums

Read More