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TUNING-BRAKES SIGNED

Fine-tuning the brain’s brakes – modulating inhibitory control with transcranial alternating current stimulation

Total Cost €

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EC-Contrib. €

0

Partnership

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 TUNING-BRAKES project word cloud

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Project "TUNING-BRAKES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2022-10-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 165˙598.00

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 Project objective

Inhibitory control over unwanted thoughts, emotions and movements is essential for effective interaction with our environment. This becomes particularly evident when there is too little inhibition, as in obsessive-compulsive disorder or Tourette’s syndrome, or too much, as in Parkinson’s disease. Recent evidence links successful inhibition to the power of neural oscillations in the beta band (15-30Hz) in a circuit involving the frontal cortex and the subthalamic nucleus. While this is an important step forward, it is not yet sufficient to develop effective neuromodulatory treatments for inhibitory control disorders. For that, we need to understand how the beta oscillations mediate neuronal communication within the fronto-subthalamic circuit. In this proposal, I address this challenging question through novel applications of transcranial alternating current stimulation (tACS). This non-invasive brain stimulation technique aligns neuronal oscillations to an oscillating low-intensity electrical current applied to the brain. This external control over oscillatory power and phase will allow me to investigate: (1) the functional relevance of beta oscillatory phase, and (2) the causal role of interactions between beta oscillations and other frequency bands (‘cross-frequency coupling’). Subsequently, I will develop an innovative, non-invasive, treatment strategy for inhibitory control deficits, by recording and modulating abnormal circuit activity only when present. Maastricht University is the ideal place to perform this research program as it is one of the only institutes in the world that has access to a new generation of deep brain stimulators, enabling concurrent recording of cortical and subthalamic activity, and it houses one of the pioneering groups in using oscillation-based non-invasive brain stimulation. Integration within this multidisciplinary team will offer an exceptional opportunity to increase my skill set, and capability to launch my own research group.

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