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PITBUL SIGNED

Point-of-Care implementation of TB testing with ultra-fast Local Heating PCR

Total Cost €

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EC-Contrib. €

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Partnership

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 PITBUL project word cloud

Explore the words cloud of the PITBUL project. It provides you a very rough idea of what is the project "PITBUL" about.

break    local    exploding    resistant    incidence    ambition    instruments    strains    proven    disposable    eastern    wrong    tb    resistance    active    instrument    lpcr    poct    pathogen    software    healthcare    rates    pathogens    clinical    demonstration    baltic    fast    decision    ultimately    countries    space    epidemiological    drug    heating    leaving    centers    ultra    tuberculosis    specialized    cartridge    detection    clinics    infect    causing    confer    building    imply    markers    contender    unmet    carry    mainly    clinically    migration    mutations    care    panel    reagents    community    human    workflow    lab    facilities    made    patterns    highest    molecular    hospitals    jails    patient    infected    germany    automated    escapes    commercial    pcr    impacting    point    latvia    mobility    15    spreading    tracking    italy    shelter    sensitive    mdr    onboard    trl    multiplexed    capacity    epidemic    tanzania    detected    population    region    prototype    thought    cloud    surge    globally    treatment    capture    mutation   

Project "PITBUL" data sheet

The following table provides information about the project.

Coordinator
GNA BIOSOLUTIONS GMBH 

Organization address
address: Am Klopferspitz 19
city: Martinsried
postcode: 82152
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.pitbul-project.eu
 Total cost 3˙858˙771 €
 EC max contribution 3˙858˙771 € (100%)
 Programme 1. H2020-EU.2.1.1.1. (A new generation of components and systems: Engineering of advanced embedded and energy and resource efficient components and systems)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-X-KET-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GNA BIOSOLUTIONS GMBH DE (Martinsried) coordinator 1˙643˙490.00
2    ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO IT (ROMA) participant 647˙811.00
3    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 484˙852.00
4    TATAA BIOCENTER AB SE (GOTEBORG) participant 368˙750.00
5    MULTID ANALYSES AB SE (GOTEBORG) participant 325˙000.00
6    LATVIJAS UNIVERSITATE LV (RIGA) participant 307˙617.00
7    DODOMA REGION TZ (DODOMA) participant 81˙250.00

Map

 Project objective

The overall goal of this project is to bring the unique, ultra-fast Local Heating PCR technology and its current lab-proven prototype instruments from TRL 4 up to TRL 6 into clinical demonstration in tuberculosis centers in Italy, Latvia, and Tanzania. This will imply a fully automated workflow on the instrument and all necessary reagents onboard of the integrated disposable cartridge, and a cloud based software for tracking epidemiological patterns.

The application, ultra-fast point-of-care testing (POCT) for tuberculosis (TB) as well as emerging TB resistance markers, is an unmet healthcare need, not only in Europe, but globally. About one third of the human population is thought to carry the pathogen. One patient with active TB can typically infect 10-15 others. In the EU, the highest incidence rates are observed in Eastern Europe and the Baltic region. Furthermore, a very recent surge has been observed in some EU countries, e.g. in Germany, mainly due to higher mobility and migration. On top of this, multi-drug resistant (MDR) TB strains are becoming epidemic, causing exploding treatment costs.

Active tuberculosis needs to be rapidly detected at hospitals, in- and out-patient clinics, specialized TB centers, jails, community centers, and shelter facilities. Such a test should be highly sensitive and capture all of the clinically relevant mutations that confer resistance in TB; if only one mutation escapes detection, the wrong treatment decision might be made, leaving the patient infected and capable of spreading resistant pathogens. Therefore, a panel of multiplexed markers will be adopted to LPCR in this project.

It is ultimately the project’s ambition to develop a European-based contender in the emerging molecular POCT system space. The integrated TB/MDR TB LPCR system, a break-through-technology, aims specifically at impacting healthcare, TB knowledge and capacity building, and enabling future commercial success of the products.

 Deliverables

List of deliverables.
Website (and Data Management Plan, and online repository) set up Websites, patent fillings, videos etc. 2019-09-10 10:58:05

Take a look to the deliverables list in detail:  detailed list of PITBUL deliverables.

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The information about "PITBUL" are provided by the European Opendata Portal: CORDIS opendata.

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