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OSCILLOGEL SIGNED

An enzyme-based self-oscillating gel

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 OSCILLOGEL project word cloud

Explore the words cloud of the OSCILLOGEL project. It provides you a very rough idea of what is the project "OSCILLOGEL" about.

merely    continual    functions    synthetic    oscillation    corresponding    enzyme    fit    power    interdependence    load    stress    collective    big    off    individually    immobilized    material    coupled    chemical    continuous    components    oscillatory    biological    forwards    subsystems    lifts    reactants    mostly    models    dynamic    chemistry    drive    fresh    clue    elasticity    mechanics    motion    emerges    obtain    unreacted    structural    understand    mechanical    linked    urease    biocompatible    swells    mechano    chemoresponsive    rigid    wish    lacking    property    diffusion    intrinsic    urea    energy    engineer    uniform    itself    operated    opening    reaction    vice    gel    insufficiently    biochemistry    responsive    pull    constant    oscillator    inconvenience    maintained    underlying    periodic    arise    external    autonomous    living    motility    found    regulatory    release    biologically    stimuli    lacks    hydrogel    self    force    generally    eliminated    counterintuitive    source    inorganic    shrinks    popular    closing    valve    first    loops    morphogenesis    versa    though    environment    exploring    feedback    differentiation    periodicity    reactions    transport    flow    attributed    lowers    biochemical   

Project "OSCILLOGEL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 183˙454.00

Map

 Project objective

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems. I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this autonomous system could fit to engineer regulatory functions by opening-closing a valve or to obtain biologically meaningful chemical responses by applying a force (pull, release) and vice versa.

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The information about "OSCILLOGEL" are provided by the European Opendata Portal: CORDIS opendata.

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