Opendata, web and dolomites


An enzyme-based self-oscillating gel

Total Cost €


EC-Contrib. €






 OSCILLOGEL project word cloud

Explore the words cloud of the OSCILLOGEL project. It provides you a very rough idea of what is the project "OSCILLOGEL" about.

biochemical    shrinks    biologically    interdependence    self    understand    models    flow    release    counterintuitive    lowers    found    individually    chemoresponsive    eliminated    obtain    stimuli    exploring    valve    motility    subsystems    periodic    pull    morphogenesis    mechanics    enzyme    diffusion    biological    lacks    rigid    stress    linked    dynamic    urea    property    inorganic    reactions    big    continual    versa    continuous    closing    chemical    oscillation    oscillatory    motion    energy    chemistry    responsive    hydrogel    lifts    autonomous    mostly    synthetic    biochemistry    though    arise    oscillator    vice    opening    components    intrinsic    transport    constant    fresh    functions    fit    wish    periodicity    force    popular    engineer    reactants    loops    inconvenience    swells    reaction    biocompatible    drive    merely    collective    feedback    corresponding    urease    material    elasticity    off    lacking    unreacted    load    itself    differentiation    power    generally    emerges    immobilized    environment    operated    underlying    living    mechanical    clue    regulatory    attributed    insufficiently    source    maintained    structural    external    forwards    uniform    first    coupled    mechano    gel   

Project "OSCILLOGEL" data sheet

The following table provides information about the project.


Organization address
postcode: S10 2TN

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 183˙454.00


 Project objective

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems. I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this autonomous system could fit to engineer regulatory functions by opening-closing a valve or to obtain biologically meaningful chemical responses by applying a force (pull, release) and vice versa.

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The information about "OSCILLOGEL" are provided by the European Opendata Portal: CORDIS opendata.

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