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An enzyme-based self-oscillating gel

Total Cost €


EC-Contrib. €






 OSCILLOGEL project word cloud

Explore the words cloud of the OSCILLOGEL project. It provides you a very rough idea of what is the project "OSCILLOGEL" about.

operated    force    swells    continuous    release    biologically    popular    reactions    gel    shrinks    chemical    pull    functions    biochemistry    fresh    oscillation    valve    emerges    though    underlying    motion    biological    feedback    living    urease    coupled    merely    generally    itself    urea    chemistry    motility    property    first    energy    opening    uniform    individually    mechano    biochemical    stress    linked    constant    models    intrinsic    collective    periodic    flow    enzyme    immobilized    engineer    responsive    lowers    power    vice    forwards    clue    inorganic    biocompatible    fit    mostly    differentiation    source    off    mechanical    mechanics    big    closing    reactants    external    understand    components    versa    lacking    diffusion    exploring    inconvenience    found    loops    morphogenesis    reaction    lacks    periodicity    autonomous    stimuli    self    chemoresponsive    obtain    arise    wish    synthetic    insufficiently    lifts    unreacted    environment    oscillatory    dynamic    elasticity    continual    structural    hydrogel    counterintuitive    eliminated    corresponding    drive    attributed    material    regulatory    rigid    interdependence    subsystems    maintained    load    transport    oscillator   

Project "OSCILLOGEL" data sheet

The following table provides information about the project.


Organization address
postcode: S10 2TN

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 183˙454.00


 Project objective

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems. I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this autonomous system could fit to engineer regulatory functions by opening-closing a valve or to obtain biologically meaningful chemical responses by applying a force (pull, release) and vice versa.

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The information about "OSCILLOGEL" are provided by the European Opendata Portal: CORDIS opendata.

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