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OSCILLOGEL SIGNED

An enzyme-based self-oscillating gel

Total Cost €

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EC-Contrib. €

0

Partnership

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 OSCILLOGEL project word cloud

Explore the words cloud of the OSCILLOGEL project. It provides you a very rough idea of what is the project "OSCILLOGEL" about.

first    components    lacks    fit    synthetic    feedback    off    engineer    periodicity    opening    popular    biological    loops    load    mechanics    structural    dynamic    release    periodic    inconvenience    motion    continual    gel    merely    immobilized    autonomous    motility    flow    understand    models    individually    reactants    though    generally    exploring    obtain    enzyme    biologically    reaction    intrinsic    chemoresponsive    self    biochemical    oscillatory    elasticity    urease    constant    mechanical    biochemistry    coupled    underlying    big    operated    clue    energy    wish    insufficiently    differentiation    subsystems    inorganic    reactions    corresponding    environment    attributed    maintained    chemical    oscillator    shrinks    pull    biocompatible    linked    forwards    drive    arise    rigid    morphogenesis    responsive    chemistry    oscillation    functions    swells    collective    material    closing    found    transport    mechano    lifts    lowers    stimuli    source    vice    regulatory    power    itself    interdependence    living    external    continuous    uniform    urea    emerges    eliminated    fresh    counterintuitive    versa    property    lacking    force    unreacted    hydrogel    stress    mostly    diffusion    valve   

Project "OSCILLOGEL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 183˙454.00

Map

 Project objective

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems. I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this autonomous system could fit to engineer regulatory functions by opening-closing a valve or to obtain biologically meaningful chemical responses by applying a force (pull, release) and vice versa.

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The information about "OSCILLOGEL" are provided by the European Opendata Portal: CORDIS opendata.

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