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OSCILLOGEL SIGNED

An enzyme-based self-oscillating gel

Total Cost €

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EC-Contrib. €

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Partnership

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 OSCILLOGEL project word cloud

Explore the words cloud of the OSCILLOGEL project. It provides you a very rough idea of what is the project "OSCILLOGEL" about.

living    motion    synthetic    gel    drive    biochemical    emerges    continual    responsive    swells    urease    fit    vice    self    valve    environment    first    maintained    load    linked    components    chemical    enzyme    lowers    versa    motility    structural    generally    models    stress    obtain    urea    individually    clue    uniform    popular    morphogenesis    reactants    exploring    force    periodic    pull    coupled    lacking    big    material    autonomous    arise    fresh    reaction    understand    though    lifts    intrinsic    continuous    chemistry    itself    collective    feedback    biocompatible    functions    found    lacks    closing    reactions    biological    unreacted    engineer    off    regulatory    flow    periodicity    hydrogel    oscillation    external    mechanics    energy    immobilized    inconvenience    inorganic    biochemistry    biologically    power    counterintuitive    oscillator    loops    wish    eliminated    merely    subsystems    rigid    forwards    shrinks    interdependence    dynamic    diffusion    corresponding    mechanical    source    underlying    oscillatory    mostly    differentiation    operated    elasticity    transport    mechano    insufficiently    release    constant    attributed    opening    chemoresponsive    property    stimuli   

Project "OSCILLOGEL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 183˙454.00

Map

 Project objective

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems. I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this autonomous system could fit to engineer regulatory functions by opening-closing a valve or to obtain biologically meaningful chemical responses by applying a force (pull, release) and vice versa.

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