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OSCILLOGEL SIGNED

An enzyme-based self-oscillating gel

Total Cost €

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EC-Contrib. €

0

Partnership

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 OSCILLOGEL project word cloud

Explore the words cloud of the OSCILLOGEL project. It provides you a very rough idea of what is the project "OSCILLOGEL" about.

autonomous    rigid    reaction    material    maintained    coupled    exploring    generally    hydrogel    emerges    arise    lowers    biocompatible    attributed    responsive    source    off    chemical    release    transport    merely    biological    immobilized    mechanics    constant    gel    biochemistry    individually    enzyme    though    eliminated    motility    versa    stimuli    external    obtain    dynamic    morphogenesis    property    itself    underlying    mechanical    closing    linked    subsystems    corresponding    force    elasticity    feedback    lacks    synthetic    differentiation    flow    popular    urea    oscillator    structural    understand    oscillation    inorganic    valve    inconvenience    periodic    wish    interdependence    biologically    stress    reactants    opening    lifts    mostly    continuous    living    functions    forwards    continual    self    first    collective    biochemical    insufficiently    operated    pull    urease    motion    uniform    fit    shrinks    big    clue    models    fresh    loops    unreacted    lacking    components    swells    power    reactions    diffusion    chemoresponsive    environment    intrinsic    chemistry    regulatory    found    periodicity    load    engineer    mechano    counterintuitive    energy    drive    vice    oscillatory   

Project "OSCILLOGEL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 183˙454.00

Map

 Project objective

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems. I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this autonomous system could fit to engineer regulatory functions by opening-closing a valve or to obtain biologically meaningful chemical responses by applying a force (pull, release) and vice versa.

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The information about "OSCILLOGEL" are provided by the European Opendata Portal: CORDIS opendata.

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