Opendata, web and dolomites

BCSC-ST

Breast cancer stem-like cells specific vulnerabilities: focus in HER2 over-expression and protein glycosylation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "BCSC-ST" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.ncl.ac.uk/medicalsciences/contact/team/profile/rodriguezbarruecoruth.html
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 195˙454.00

Map

 Project objective

Breast cancer is the most common cause of female cancer death in Europe, hence it is urgent finding alternative treatments. A small population of cells that display stem cell characteristics has been described in breast cancer (BCSC) and linked to tumour progression, resistance to treatment and metastasis. New therapeutic approaches propose the use of stem cell targeting agents in combination with traditional chemotherapy. However, selective targeting of BCSC is still challenging as they are very similar to normal stem cells. Here, I propose to probe two characteristics that may be specific of BCSC: HER2 over-expression and altered protein glycosylation. I will use state-of-the-art technologies including the standardization of a new protocol to isolate Circulating Tumour Cells (CTCs) from blood, and the generation of a library of CRISPRs targeting all the genes related with protein glycosylation. After six years of postdoctoral stage in New York, I have wide experience in RNAi screens valuable for the library development. Supervised by Prof. Elliott at Newcastle University, I aim to learn the insights of protein glycosylation in cancer. The identification of BCSC specific vulnerabilities has important clinical implications as they represent outstanding candidates for new targeted therapies. Importantly, HER2 and protein glycosylation are mainly located in the surface of the cells, being accessible to targeting agents. The accomplishment of the proposal will contribute to my development as an independent researcher since I will: 1) gain knowledge in BCSC and protein glycosylation, fields with multiple functional implications; 2) generate data to use in my future projects, including a list of targeted therapies candidates; 3) standardize a method for isolating CTCs to further study breast cancer metastasis; 4) learn to use CRISPR libraries and generate a library with multiple applications; and 5) be trained and guided in the transition to a full autonomous position.

 Publications

year authors and title journal last update
List of publications.
2017 Ruth Rodriguez-Barrueco, Erin A. Nekritz, François Bertucci, Jiyang Yu, Felix Sanchez-Garcia, Tizita Z. Zeleke, Andrej Gorbatenko, Daniel Birnbaum, Elena Ezhkova, Carlos Cordon-Cardo, Pascal Finetti, David Llobet-Navas, Jose M. Silva
miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy
published pages: 553-566, ISSN: 0890-9369, DOI: 10.1101/gad.292318.116
Genes & Development 31/6 2019-06-11

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BCSC-ST" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BCSC-ST" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MIGPSC (2018)

Shaping the European Migration Policy: the role of the security industry

Read More  

RESTRICTIONAPP (2019)

A multilinear approach to the restriction problem with applications to geometric measure theory, the Schrödinger equation and inverse problems

Read More  

NPsVLCD (2019)

Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease

Read More