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PROCHIP SIGNED

Chromatin organization PROfiling with high-throughput super-resolution microscopy on a CHIP

Total Cost €

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EC-Contrib. €

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Partnership

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 PROCHIP project word cloud

Explore the words cloud of the PROCHIP project. It provides you a very rough idea of what is the project "PROCHIP" about.

laser    frontier    pathogenic    heterogeneities    samples    predicting    microenvironment    toxicity    scientists    formed    chip    integrate    benchmarks    accurate    resistance    throughput    cancer    micromachining    fluorescence    scanned    technologies    microfluidics    company    responsiveness    illumination    chromatin    3d    computer    guidance    thousands    disease    genetic    coin    fashion    femtosecond    force    diagnosis    tumor    permit    components    photo    diffraction    single    heterogeneity    epigenetics    device    photonics    minimal    brand    functional    causing    decipher    tumorigenesis    precision    possibilities    influenced    waveguides    fabricating    therapeutic    sciences    optofluidic    types    profile    microfluidic    cell    epigenetic    differential    driving    opening    domains    microscope    cells    lenses    limit    young    universities    analyze    therapies    hundreds    data    smaller    outcome    resolution    none    biological    channels    glass    progression    imaging    fluidic    microchannels    medical    substrate    super    organization    automatic    function    excitation    movement   

Project "PROCHIP" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://pro-chip.eu/
 Total cost 2˙496˙525 €
 EC max contribution 2˙496˙525 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 601˙250.00
2    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 511˙880.00
3    ELVESYS FR (PARIS) participant 499˙271.00
4    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) participant 492˙873.00
5    INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON FR (VILLEURBANNE CEDEX) participant 360˙250.00
6    UNIVERSITE D'ANGERS FR (ANGERS CEDEX 01) participant 31˙000.00

Map

 Project objective

Cancer is both a genetic and an epigenetic disease whose outcome is influenced by tumor microenvironment, which represents the major driving force of tumorigenesis causing the functional heterogeneity observed in most cancer types. Defining the 3D-organization of cancer-associated chromatin domains would represent a new frontier to decipher tumor heterogeneity. None of the currently available technologies permit to rapidly analyze thousands of cells and profile their chromatin organization at single cell level, as needed for medical diagnosis and therapeutic guidance. The goal of the project is to build a high-throughput super-resolution microscope in a microfluidic chip smaller than a coin. With this device we will provide high resolution imaging of hundreds of cells at the diffraction limit and beyond, with minimal photo-toxicity. Femtosecond laser micromachining allows fabricating with accurate precision optofluidic components as waveguides, microchannels and lenses in a glass substrate. We will integrate them in a single chip, to achieve the required illumination path for advanced fluorescence excitation and sample movement: in the same chip biological samples will be scanned along fluidic channels in a fully automatic fashion. High-throughput data on chromatin distribution in hundreds of samples will be generated, allowing to decipher the pathogenic function of tumor heterogeneities in tumor progression. These data will be used as benchmarks for predicting differential responsiveness and/or resistance of cancer cells to targeted therapies opening brand new possibilities for medical diagnosis and therapeutic guidance. The consortium is formed by young scientists from Universities in the field of photonics, computer sciences and epigenetics, and a leading company in microfluidics.

 Publications

year authors and title journal last update
List of publications.
2019 Andrea Crespi, Roberto Osellame, Francesca Bragheri
Femtosecond-laser-written optofluidics in alumino-borosilicate glass
published pages: 100042, ISSN: 2590-1478, DOI: 10.1016/j.omx.2019.100042
Optical Materials: X 4 2020-02-06
2019 Authors Ali Ahmad, Carole Frindel, David Rousseau
Détection de différence de densité de marqueurs fluorescents en microscopie superrésolue : approche pointilliste ou texturale ?
published pages: , ISSN: , DOI:
2019-12-16
2019 Ali Ahmad, Carole Frindel, Pejman Rasti, David Sarrut, David Rousseau
Deep learning based detection of cells in 3D light sheet fluorescence microscopy
published pages: , ISSN: , DOI:
Quantitative BioImaging Conference 2019-12-16
2019 Federico Sala, Petra Paiè, Roberto Memeo, Roberto Osellame, Andrea Farina, Andrea Bassi, Francesca Bragheri
Optofluidic lab-on-chips for high throughput 3D imaging of cells and tissues
published pages: 11002, ISSN: 2100-014X, DOI: 10.1051/epjconf/201921511002
EPJ Web of Conferences 215 2019-11-20

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The information about "PROCHIP" are provided by the European Opendata Portal: CORDIS opendata.

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