Opendata, web and dolomites

Huntingtin hPSC

Unraveling huntingtin function in cortical and striatal human development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Huntingtin hPSC project word cloud

Explore the words cloud of the Huntingtin hPSC project. It provides you a very rough idea of what is the project "Huntingtin hPSC" about.

remove    huntingtin    later    huntington    psc    populations    pro    transcriptional    htt    cortical    adulthood    cortex    expansion    mouse    gene    shown    poorly    proteins    trafficking    expression    stage    striatal    defects    causes    hd    stem    cells    survival    caused    occurring    lines    differentiated    neuronal    functional    motor    mid    vesicular    full    pluripotent    cag    human    pathology    cell    differentiation    dysfunction    arborization    phenotypes    progenitor    models    conditional    born    neurodevelopmental    mitotic    monogenetic    generate    disease    suggest    brain    cytoplasm    inside    neurodegenerative    dissected    function    roles    cognitive    autosomic    apoptotic    deficits    rare    regulator    manifested    anti    absence    genetic    migration    neurons    date    neural    overview    life    repeat    dendritic    give    severe    dissect    transporter    dominant    knock    nucleus    developmental    maturation    showed    protein    disrupt    disorder    fate    microtubules    symptoms   

Project "Huntingtin hPSC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.cattaneolab.it/
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 180˙277.00

Map

 Project objective

Huntington's disease (HD) is a rare neurodegenerative autosomic dominant disorder that causes severe motor dysfunction and cognitive deficits. Although HD main symptoms are manifested at mid-life, increasing evidence suggest that early neurodevelopmental defects may contribute to the late pathology. HD is a monogenetic disorder caused by a CAG repeat expansion inside the huntingtin gene (Htt). The functional role of Htt has been widely studied as a pro-survival anti-apoptotic factor, a regulator of vesicular trafficking along microtubules, a transporter of proteins between nucleus and cytoplasm, and a transcriptional role, however it’s main role in the brain during development and later adulthood is still poorly understood. Recently, genetic mouse models have shown that the loss of huntingtin from the brain at an early stage of development results in mitotic neural progenitor defects that disrupt cell fate in the cortex. In addition, the same study showed that loss-of-function of huntingtin specifically in early born neurons showed neuronal migration and neuronal dendritic arborization defects. However, to date, no studies have addressed and dissected the different roles of the human huntingtin protein in human cortical and striatal development specifically in different cell populations, or the effects of early phenotypes caused by loss-of-function of huntingtin in the late neuronal function. Here, I will study and dissect the function of human huntingtin during human development using human pluripotent stem cells (PSC) differentiated towards cortical and striatal neurons. Through this project I will generate several conditional knock out and full knock out human PSC lines to remove Htt expression specifically from different neuronal cell populations. Overall, all these analyses will give an overview of the developmental changes occurring in the absence of Htt function during cortical and striatal differentiation and neuronal maturation.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HUNTINGTIN HPSC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HUNTINGTIN HPSC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EPIC (2019)

Evolution of Planktonic Gastropod Calcification

Read More  

GenEl (2020)

General readout electronics for cross-sectoral application in European research infrastructure

Read More  

SOCIALEU (2019)

The missing pillar. European social policy and Eurosceptic challenges (SOCIALEU)

Read More