Opendata, web and dolomites

MS SPIDOC SIGNED

Mass Spectrometry for Single Particle Imaging of Dipole Oriented protein Complexes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MS SPIDOC project word cloud

Explore the words cloud of the MS SPIDOC project. It provides you a very rough idea of what is the project "MS SPIDOC" about.

imaging    single    free    accessible    spi    times    wealth    molecular    gas    movies    facility    entered    orient    identification    area    xfel    proteins    resolution    transient    particles    time    tremendously    stage    risk    expertise    unfolding    native    biomolecular    components    dipole    peak    industry    instrument    environment    speeding    combined    biomolecules    strengthen    axis    market    particle    ray    datasets    overcome    pattern    consumption    renders    microscopy    reconstruct    structural    spidoc    operation    repetition    smaller    limited    computer    viral    separated    data    structure    opened    unparalleled    generation    ms    em    spectrometry    electron    protein    crystallization    named    rate    internationally    conformation    yielding    thereby    brilliance    reconstruction    derive    easing    image    structures    background    conformational    era    bottleneck    mass    oriented    simulations    combines    orientation    lasers    complexes    machines    give   

Project "MS SPIDOC" data sheet

The following table provides information about the project.

Coordinator
HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE 

Organization address
address: MARTINISTRASSE 52
city: HAMBURG
postcode: 20251
website: www.hpi-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.ms-spidoc.eu
 Total cost 3˙730˙000 €
 EC max contribution 3˙730˙000 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE DE (HAMBURG) coordinator 499˙125.00
2    EUROPEAN X-RAY FREE-ELECTRON LASERFACILITY GMBH DE (SCHENEFELD) participant 600˙000.00
3    FASMATECH EPISTIMONIKI KAI TECHNOLOGIKI ANONYMI ETAIREIA EL (AFIDNES ATTIKIS) participant 587˙500.00
4    UPPSALA UNIVERSITET SE (UPPSALA) participant 512˙500.00
5    SPECTROMETRY VISION BV NL (ALMERE) participant 432˙500.00
6    UNIVERSITAET GREIFSWALD DE (GREIFSWALD) participant 421˙000.00
7    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 362˙375.00
8    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) participant 315˙000.00

Map

 Project objective

The European XFEL has just entered user operation. With its unparalleled peak brilliance and repetition rate, European XFEL has the potential to further applications in single particle imaging (SPI), thus far limited to large viral particles at X-ray Free-Electron Lasers (XFEL). SPI will allow imaging protein complexes without the need for crystallization. This eventually renders transient conformational states accessible for high resolution structural studies yielding molecular movies of biomolecular machines. A major bottleneck is the wealth of data required to reconstruct a single structure leading to long processing times. This is currently also a problem in electron microscopy (EM). MS SPIDOC will overcome this data challenge by developing a native mass spectrometry (MS) system for sample delivery, named X-MS-I. It will provide mass and conformation selected biomolecules, which are oriented along their dipole axis upon imaging. This will enable structural reconstruction from much smaller datasets speeding up the analysis time tremendously. Moreover, the system features low sample consumption and a controlled low background easing pattern identification. The main objectives of the project are: • Deliver mass and conformation separated biomolecules for SPI. • Orient proteins for SPI. • Image protein complex unfolding • Exploit potential of protein orientation for other applications The MS SPIDOC consortium combines internationally leading expertise in different fields relevant to the project: Instrument design and development, computer simulations as well as working with biomolecules in the gas phase and on SPI are combined to implement the novel sample environment at the next generation XFEL facility. New components and methods will be opened to the market and thereby strengthen the European Research Area (ERA) and industry. This early stage high-risk project will give rise to a new technology with major impact on how to derive structures of biomolecules.

 Deliverables

List of deliverables.
Dissemination and Exploitation plan Documents, reports 2020-02-12 17:33:30
Instrumental settings for structural integrity Documents, reports 2020-02-12 17:33:23
Data management plan Open Research Data Pilot 2020-02-12 17:33:27
Stability range and charge distribution of electrosprayed ions Documents, reports 2020-02-12 17:33:23
Public and internal web services, logo Websites, patent fillings, videos etc. 2020-01-28 17:14:12

Take a look to the deliverables list in detail:  detailed list of MS SPIDOC deliverables.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MS SPIDOC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MS SPIDOC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.2.1.)

Quromorphic (2019)

Neuromrophic Quantum Computing

Read More  

INITIO (2019)

INnovative chemIcal sensors for enanTioselective detectIon of chiral pOllutants

Read More  

EDRA (2019)

Hardware-Assisted Decoupled Access Execution on the Digital Market: The EDRA Framework

Read More