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LIGHTUP SIGNED

Turning the cortically blind brain to see: from neural computations to system dynamicsgenerating visual awareness in humans and monkeys

Total Cost €

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EC-Contrib. €

0

Partnership

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 LIGHTUP project word cloud

Explore the words cloud of the LIGHTUP project. It provides you a very rough idea of what is the project "LIGHTUP" about.

functions    animal    lacking    estimating    enhanced    damage    emergence    flexibility    restoration    generating    interactions    hebbian    clinical    neuroscience    protocol    tms    monkeys    transcranial    bayesian    devastating    mechanistic    affords    associative    analyzing    directionality    population    retain    signal    first    bases    flow    despite    firm    blindsight    proven    tuning    leverages    visual    cortex    rehabilitation    human    combines    causal    intervention    neurophysiology    model    invasive    direction    receptive    computational    ones    magnetic    conscious    plasticity    blindness    training    integrate    micro    wisdom    distant    dynamic    cortical    connectivity    clarify    humans    circuits    refined    behavioural    neuroimaging    piloted    lightup    data    lost    combine    paradigm    monkey    experiential    translate    brain    behavioral    association    re    framework    place    induce    richness    devise    neurobiological    stimulation    dissociate    fmri    nonconscious    specifies    patients   

Project "LIGHTUP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TORINO 

Organization address
address: VIA GIUSEPPE VERDI 8
city: TORINO
postcode: 10124
website: www.unito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙994˙212 €
 EC max contribution 1˙994˙212 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) coordinator 1˙067˙288.00
2    STICHTING KATHOLIEKE UNIVERSITEIT BRABANT NL (TILBURG) participant 666˙923.00
3    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 260˙000.00

Map

 Project objective

Visual awareness affords flexibility and experiential richness, and its loss following brain damage has devastating effects. However, patients with blindness following cortical damage may retain visual functions, despite visual awareness is lacking (blindsight). But, how can we translate non-conscious visual abilities into conscious ones after damage to the visual cortex? To place our understanding of visual awareness on firm neurobiological and mechanistic bases, I propose to integrate human and monkey neuroscience. Next, I will translate this wisdom into evidence-based clinical intervention. First, LIGHTUP will apply computational neuroimaging methods at the micro-scale level, estimating population receptive fields in humans and monkeys. This will enable analyzing fMRI signal similar to the way tuning properties are studied in neurophysiology, and to clarify how brain areas translate visual properties into responses associated with awareness. Second, LIGHTUP leverages a behavioural paradigm that can dissociate nonconscious visual abilities from awareness in monkeys, thus offering a refined animal model of visual awareness. Applying behavioural-Dynamic Causal Modelling to combine fMRI and behavioral data, LIGHTUP will build up a Bayesian framework that specifies the directionality of information flow in the interactions across distant brain areas, and their causal role in generating visual awareness. In the third part, I will devise a rehabilitation protocol that combines brain stimulation and visual training to promote the (re)emergence of lost visual awareness. LIGHTUP will exploit non-invasive transcranial magnetic stimulation (TMS) in a novel protocol that enables stimulation of complex cortical circuits and selection of the direction of connectivity that is enhanced. This associative stimulation has been proven to induce Hebbian plasticity, and we have piloted its effects in fostering visual awareness in association with visual restoration training.

 Publications

year authors and title journal last update
List of publications.
2019 Alessia Celeghin, Arianna Bagnis, Matteo Diano, Carlos Andrés Méndez, Tommaso Costa, Marco Tamietto
Functional neuroanatomy of blindsight revealed by activation likelihood estimation meta-analysis
published pages: 109-118, ISSN: 0028-3932, DOI: 10.1016/j.neuropsychologia.2018.06.007
Neuropsychologia 128 2020-04-15
2019 James Danckert, Marco Tamietto, Yves Rossetti
Definition: Blindsight
published pages: 569-570, ISSN: 0010-9452, DOI: 10.1016/j.cortex.2019.01.027
Cortex 119 2020-04-15
2019 Arianna Bagnis, Alessia Celeghin, Cristina Onesta Mosso, Marco Tamietto
Toward an integrative science of social vision in intergroup bias
published pages: 318-326, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2019.04.020
Neuroscience & Biobehavioral Reviews 102 2020-04-15
2019 Loraine Georgy, Bert Jans, Marco Tamietto, Alain Ptito
Functional reorganization of population receptive fields in a hemispherectomy patient with blindsight
published pages: 198-203, ISSN: 0028-3932, DOI: 10.1016/j.neuropsychologia.2018.06.026
Neuropsychologia 128 2020-04-15
2020 Elizabeth S. Paul, Shlomi Sher, Marco Tamietto, Piotr Winkielman, Michael T. Mendl
Towards a comparative science of emotion: Affect and consciousness in humans and animals
published pages: 749-770, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2019.11.014
Neuroscience & Biobehavioral Reviews 108 2020-04-15
2019 Alessia Celeghin, Valentina Galetto, Marco Tamietto, Marina Zettin
Emotion Recognition in Low-Spatial Frequencies Is Partly Preserved following Traumatic Brain Injury
published pages: 1-10, ISSN: 2314-6133, DOI: 10.1155/2019/9562935
BioMed Research International 2019 2020-04-15
2019 Marco Tamietto, Robert W. Kentridge
Standing on the shoulders of a giant
published pages: 2-5, ISSN: 0028-3932, DOI: 10.1016/j.neuropsychologia.2019.04.020
Neuropsychologia 128 2020-04-15
2020 Elisabetta Palagi, Alessia Celeghin, Marco Tamietto, Piotr Winkielman, Ivan Norscia
The neuroethology of spontaneous mimicry and emotional contagion in human and non-human animals
published pages: 149-165, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2020.01.020
Neuroscience & Biobehavioral Reviews 111 2020-04-15
2018 Beatrice de Gelder, Rebecca Watson, Minye Zhan, Matteo Diano, Marco Tamietto, Maarten J. Vaessen
Classical paintings may trigger pain and pleasure in the gendered brain
published pages: 171-180, ISSN: 0010-9452, DOI: 10.1016/j.cortex.2018.09.011
Cortex 109 2020-04-15
2019 Matthias Michel, Diane Beck, Ned Block, Hal Blumenfeld, Richard Brown, David Carmel, Marisa Carrasco, Mazviita Chirimuuta, Marvin Chun, Axel Cleeremans, Stanislas Dehaene, Stephen M. Fleming, Chris Frith, Patrick Haggard, Biyu J. He, Cecilia Heyes, Melvyn A. Goodale, Liz Irvine, Mitsuo Kawato, Robert Kentridge, Jean-Remi King, Robert T. Knight, Sid Kouider, Victor Lamme, Dominique Lamy, Hakwan Lau
Opportunities and challenges for a maturing science of consciousness
published pages: 104-107, ISSN: 2397-3374, DOI: 10.1038/s41562-019-0531-8
Nature Human Behaviour 3/2 2020-04-15
2018 Hisao Nishijo, Robert Rafal, Marco Tamietto
Editorial: Limbic-Brainstem Roles in Perception, Cognition, Emotion, and Behavior
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00395
Frontiers in Neuroscience 12 2020-03-05

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The information about "LIGHTUP" are provided by the European Opendata Portal: CORDIS opendata.

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