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CircaCHIP SIGNED

Development of Circadian Rhythms on Chip

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CircaCHIP project word cloud

Explore the words cloud of the CircaCHIP project. It provides you a very rough idea of what is the project "CircaCHIP" about.

toxicity    self    metabolism    rhythms    groundbreaking    pharmaceutical    responsible    et    tissue    diseases    fatty    vitro    differences    physiological    prevalent    temperature    physiology    bavli    liver    expandable    circadian    assembled    platform    nature    predict    describe    oscillations    generation    pressing    troglitazone    create    properly    animal    regulation    pnas    idiopathic    dynamically    cutting    environment    little    idiosyncratic    hepatocytes    limited    interventions    highlighted    lack    captures    hormonal    synchronization    systemic    formulate    chip    biotechnology    metabolic    tracks    models    drugs    leap    efficient    nutritional    dynamics    chronopharmacology    microfluidic    hormones    levy    pharmacokinetics    inverted    mimic    libraries    predicting    obesity    acetaminophen    drug    night    2016    rational    explained    al    dependent    function    capability    human    pharmaceuticals    edge    complexity    responding    quantum    efforts    2015    time    model    changing    livers    day    compounded    disease    inability    cycles    stems    micro    diabetes    clearance   

Project "CircaCHIP" data sheet

The following table provides information about the project.

Coordinator		 THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Israel [IL]
 Total cost 149˙969 €
 EC max contribution 149˙969 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 149˙969.00

Map

 Project objective

The liver is responsible for the systemic regulation of human metabolism, responding to a dynamically changing hormonal and nutritional environment. These physiological dynamics limited our ability to model human metabolism in our efforts to create efficient pharmaceutical interventions for prevalent metabolic diseases, such as fatty liver disease, obesity, and type-2 diabetes. In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. Chronopharmacology). The problem stems from our inability to model the dynamics of human metabolism in vitro, and compounded by the failure of animal models to predict human response due to differences in physiology, metabolic regulation, and an inverted day/night cycles. In addition, in vitro hepatocytes show little to no metabolic function and lack the physiological complexity of human tissue. Therefore, there is a pressing need to develop models that mimic human physiological complexity. Recently, we established groundbreaking libraries of expandable human hepatocytes (Levy et al. Nature Biotechnology 2015) and a cutting-edge liver-on-chip platform that tracks metabolic dynamics in real time (Bavli et al. PNAS 2016). Our technology explained the idiopathic toxicity of acetaminophen and the idiosyncratic toxicity of troglitazone and was recently highlighted by the H2020 program. Here, we describe the development of a novel platform that captures the synchronization of circadian rhythms in self-assembled human micro-livers by microfluidic oscillations of temperature and hormones. Our next generation model for liver metabolism will present a quantum leap in capability, offering to go beyond animal models by predicting time-of-day dependent toxicity and drug clearance. In addition, we will enable the rational design of a new generation of pharmaceuticals

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The information about "CIRCACHIP" are provided by the European Opendata Portal: CORDIS opendata.

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