Opendata, web and dolomites

CircaCHIP SIGNED

Development of Circadian Rhythms on Chip

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CircaCHIP project word cloud

Explore the words cloud of the CircaCHIP project. It provides you a very rough idea of what is the project "CircaCHIP" about.

levy    pharmaceuticals    rational    self    micro    drug    dependent    et    bavli    regulation    changing    compounded    responding    leap    al    libraries    little    rhythms    efficient    day    predict    idiopathic    metabolic    function    hepatocytes    properly    liver    oscillations    generation    human    diseases    chronopharmacology    cycles    drugs    microfluidic    quantum    animal    2015    temperature    inverted    livers    groundbreaking    biotechnology    efforts    describe    chip    edge    clearance    models    dynamically    systemic    synchronization    lack    prevalent    stems    physiology    diabetes    fatty    acetaminophen    vitro    hormones    toxicity    obesity    captures    responsible    environment    differences    metabolism    model    mimic    limited    capability    2016    complexity    night    expandable    nature    idiosyncratic    predicting    pressing    nutritional    disease    create    platform    circadian    tissue    pnas    highlighted    assembled    troglitazone    dynamics    tracks    cutting    interventions    explained    pharmaceutical    time    inability    physiological    hormonal    formulate    pharmacokinetics   

Project "CircaCHIP" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 149˙969 €
 EC max contribution 149˙969 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 149˙969.00

Map

 Project objective

The liver is responsible for the systemic regulation of human metabolism, responding to a dynamically changing hormonal and nutritional environment. These physiological dynamics limited our ability to model human metabolism in our efforts to create efficient pharmaceutical interventions for prevalent metabolic diseases, such as fatty liver disease, obesity, and type-2 diabetes. In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. Chronopharmacology). The problem stems from our inability to model the dynamics of human metabolism in vitro, and compounded by the failure of animal models to predict human response due to differences in physiology, metabolic regulation, and an inverted day/night cycles. In addition, in vitro hepatocytes show little to no metabolic function and lack the physiological complexity of human tissue. Therefore, there is a pressing need to develop models that mimic human physiological complexity. Recently, we established groundbreaking libraries of expandable human hepatocytes (Levy et al. Nature Biotechnology 2015) and a cutting-edge liver-on-chip platform that tracks metabolic dynamics in real time (Bavli et al. PNAS 2016). Our technology explained the idiopathic toxicity of acetaminophen and the idiosyncratic toxicity of troglitazone and was recently highlighted by the H2020 program. Here, we describe the development of a novel platform that captures the synchronization of circadian rhythms in self-assembled human micro-livers by microfluidic oscillations of temperature and hormones. Our next generation model for liver metabolism will present a quantum leap in capability, offering to go beyond animal models by predicting time-of-day dependent toxicity and drug clearance. In addition, we will enable the rational design of a new generation of pharmaceuticals

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CIRCACHIP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CIRCACHIP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More