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CircaCHIP SIGNED

Development of Circadian Rhythms on Chip

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CircaCHIP project word cloud

Explore the words cloud of the CircaCHIP project. It provides you a very rough idea of what is the project "CircaCHIP" about.

microfluidic    chronopharmacology    inability    pharmaceutical    human    quantum    pharmaceuticals    2016    levy    responding    responsible    create    dependent    assembled    explained    cycles    rhythms    hepatocytes    acetaminophen    generation    captures    nutritional    2015    bavli    interventions    cutting    self    limited    predict    obesity    leap    al    efforts    disease    drug    compounded    regulation    function    toxicity    stems    environment    formulate    tracks    clearance    lack    highlighted    micro    nature    diseases    troglitazone    day    hormones    systemic    dynamics    properly    platform    changing    animal    circadian    et    inverted    time    pharmacokinetics    expandable    model    efficient    liver    rational    tissue    mimic    metabolic    idiopathic    predicting    chip    biotechnology    dynamically    drugs    describe    pnas    physiology    oscillations    prevalent    groundbreaking    temperature    differences    night    little    fatty    diabetes    vitro    capability    livers    physiological    libraries    complexity    pressing    metabolism    hormonal    edge    synchronization    idiosyncratic    models   

Project "CircaCHIP" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 149˙969 €
 EC max contribution 149˙969 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 149˙969.00

Map

 Project objective

The liver is responsible for the systemic regulation of human metabolism, responding to a dynamically changing hormonal and nutritional environment. These physiological dynamics limited our ability to model human metabolism in our efforts to create efficient pharmaceutical interventions for prevalent metabolic diseases, such as fatty liver disease, obesity, and type-2 diabetes. In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. Chronopharmacology). The problem stems from our inability to model the dynamics of human metabolism in vitro, and compounded by the failure of animal models to predict human response due to differences in physiology, metabolic regulation, and an inverted day/night cycles. In addition, in vitro hepatocytes show little to no metabolic function and lack the physiological complexity of human tissue. Therefore, there is a pressing need to develop models that mimic human physiological complexity. Recently, we established groundbreaking libraries of expandable human hepatocytes (Levy et al. Nature Biotechnology 2015) and a cutting-edge liver-on-chip platform that tracks metabolic dynamics in real time (Bavli et al. PNAS 2016). Our technology explained the idiopathic toxicity of acetaminophen and the idiosyncratic toxicity of troglitazone and was recently highlighted by the H2020 program. Here, we describe the development of a novel platform that captures the synchronization of circadian rhythms in self-assembled human micro-livers by microfluidic oscillations of temperature and hormones. Our next generation model for liver metabolism will present a quantum leap in capability, offering to go beyond animal models by predicting time-of-day dependent toxicity and drug clearance. In addition, we will enable the rational design of a new generation of pharmaceuticals

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The information about "CIRCACHIP" are provided by the European Opendata Portal: CORDIS opendata.

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