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CircaCHIP SIGNED

Development of Circadian Rhythms on Chip

Total Cost €

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EC-Contrib. €

0

Partnership

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 CircaCHIP project word cloud

Explore the words cloud of the CircaCHIP project. It provides you a very rough idea of what is the project "CircaCHIP" about.

models    platform    toxicity    dependent    highlighted    quantum    nature    physiological    dynamically    generation    predicting    inability    model    diabetes    acetaminophen    night    metabolic    day    pressing    2015    libraries    responsible    leap    lack    function    responding    interventions    captures    self    edge    complexity    vitro    disease    pnas    cycles    pharmaceuticals    inverted    animal    compounded    biotechnology    tissue    troglitazone    idiosyncratic    capability    bavli    differences    hepatocytes    2016    predict    metabolism    dynamics    pharmacokinetics    formulate    rhythms    changing    groundbreaking    nutritional    chip    drug    expandable    describe    environment    human    create    pharmaceutical    efforts    efficient    drugs    livers    systemic    stems    hormones    cutting    limited    oscillations    levy    micro    explained    fatty    circadian    clearance    al    diseases    properly    physiology    time    prevalent    temperature    idiopathic    microfluidic    rational    tracks    et    little    assembled    hormonal    synchronization    liver    obesity    mimic    chronopharmacology    regulation   

Project "CircaCHIP" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 149˙969 €
 EC max contribution 149˙969 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 149˙969.00

Map

 Project objective

The liver is responsible for the systemic regulation of human metabolism, responding to a dynamically changing hormonal and nutritional environment. These physiological dynamics limited our ability to model human metabolism in our efforts to create efficient pharmaceutical interventions for prevalent metabolic diseases, such as fatty liver disease, obesity, and type-2 diabetes. In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. Chronopharmacology). The problem stems from our inability to model the dynamics of human metabolism in vitro, and compounded by the failure of animal models to predict human response due to differences in physiology, metabolic regulation, and an inverted day/night cycles. In addition, in vitro hepatocytes show little to no metabolic function and lack the physiological complexity of human tissue. Therefore, there is a pressing need to develop models that mimic human physiological complexity. Recently, we established groundbreaking libraries of expandable human hepatocytes (Levy et al. Nature Biotechnology 2015) and a cutting-edge liver-on-chip platform that tracks metabolic dynamics in real time (Bavli et al. PNAS 2016). Our technology explained the idiopathic toxicity of acetaminophen and the idiosyncratic toxicity of troglitazone and was recently highlighted by the H2020 program. Here, we describe the development of a novel platform that captures the synchronization of circadian rhythms in self-assembled human micro-livers by microfluidic oscillations of temperature and hormones. Our next generation model for liver metabolism will present a quantum leap in capability, offering to go beyond animal models by predicting time-of-day dependent toxicity and drug clearance. In addition, we will enable the rational design of a new generation of pharmaceuticals

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The information about "CIRCACHIP" are provided by the European Opendata Portal: CORDIS opendata.

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