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CircaCHIP SIGNED

Development of Circadian Rhythms on Chip

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 CircaCHIP project word cloud

Explore the words cloud of the CircaCHIP project. It provides you a very rough idea of what is the project "CircaCHIP" about.

inverted    environment    pharmacokinetics    metabolic    night    microfluidic    limited    self    dynamics    little    dynamically    temperature    quantum    biotechnology    rational    toxicity    2015    compounded    livers    responsible    regulation    prevalent    disease    vitro    bavli    acetaminophen    complexity    fatty    al    drugs    tissue    predicting    inability    oscillations    captures    hormones    2016    systemic    tracks    pharmaceutical    highlighted    capability    metabolism    levy    et    rhythms    edge    synchronization    time    animal    leap    stems    changing    physiology    diabetes    expandable    generation    predict    platform    idiopathic    formulate    mimic    responding    explained    obesity    dependent    circadian    describe    cutting    groundbreaking    properly    drug    pressing    chip    efficient    efforts    models    libraries    pharmaceuticals    hepatocytes    micro    nature    assembled    create    nutritional    pnas    chronopharmacology    physiological    lack    model    human    idiosyncratic    interventions    troglitazone    day    hormonal    cycles    liver    differences    function    clearance    diseases   

Project "CircaCHIP" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 149˙969 €
 EC max contribution 149˙969 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 149˙969.00

Map

 Project objective

The liver is responsible for the systemic regulation of human metabolism, responding to a dynamically changing hormonal and nutritional environment. These physiological dynamics limited our ability to model human metabolism in our efforts to create efficient pharmaceutical interventions for prevalent metabolic diseases, such as fatty liver disease, obesity, and type-2 diabetes. In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. Chronopharmacology). The problem stems from our inability to model the dynamics of human metabolism in vitro, and compounded by the failure of animal models to predict human response due to differences in physiology, metabolic regulation, and an inverted day/night cycles. In addition, in vitro hepatocytes show little to no metabolic function and lack the physiological complexity of human tissue. Therefore, there is a pressing need to develop models that mimic human physiological complexity. Recently, we established groundbreaking libraries of expandable human hepatocytes (Levy et al. Nature Biotechnology 2015) and a cutting-edge liver-on-chip platform that tracks metabolic dynamics in real time (Bavli et al. PNAS 2016). Our technology explained the idiopathic toxicity of acetaminophen and the idiosyncratic toxicity of troglitazone and was recently highlighted by the H2020 program. Here, we describe the development of a novel platform that captures the synchronization of circadian rhythms in self-assembled human micro-livers by microfluidic oscillations of temperature and hormones. Our next generation model for liver metabolism will present a quantum leap in capability, offering to go beyond animal models by predicting time-of-day dependent toxicity and drug clearance. In addition, we will enable the rational design of a new generation of pharmaceuticals

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The information about "CIRCACHIP" are provided by the European Opendata Portal: CORDIS opendata.

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