Opendata, web and dolomites


Excel in Rare Diseases’ Research: Focus on LYSOsomal Disorders and CILiopathies

Total Cost €


EC-Contrib. €






 LYSOCIL project word cloud

Explore the words cloud of the LYSOCIL project. It provides you a very rough idea of what is the project "LYSOCIL" about.

power    expects    joint    cooperation    lysosomal    stimulating    care    cedoc    biomedical    genetics    networks    center    multidisciplinary    uuml    2021    diagnosis    unlock    citations    university    reinforce    telethon    special    training    chronic    nms    national    international    scientific    collaborations    diseases    retreats    innovation    indicators    meetings    practices    journals    ciliopathies       think    forefront    nster    interactions    exchange    nova    diversity    etiology    school    lysocil    diagnostic    agendas    virtual    igm    outstanding    families    competitiveness    articulated    leverage    collaborative    internationally    rare    tigem    understand    multiple    gm    percentage    big    strategy    unl    individual    rds    20    excellence    wwu    patients    health    index    twinning    outside    rd    winter    lasting    scattered    local    satellite    network    portuguese    tanks    ftele    capacity    paramount    ecosystems    medicine    medical    publications   

Project "LYSOCIL" data sheet

The following table provides information about the project.


Organization address
city: LISBOA
postcode: 1099 085
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 967˙572 €
 EC max contribution 967˙572 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-05-2017-Twinning
 Funding Scheme CSA
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2021-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) coordinator 626˙878.00
2    FONDAZIONE TELETHON IT (ROMA) participant 183˙068.00


 Project objective

The high diversity, low numbers and scattered distribution of patients affected rare diseases (RDs) represent a big challenge for biomedical research and health care, the patients and their families. International cooperation is paramount to understand the etiology and find better diagnostic procedures for RDs. LYSOCIL addresses that need through a scientific strategy to reinforce research and innovation excellence in the study of lysosomal diseases and ciliopathies, with a special attention on the diagnosis and etiology of these diseases. The Chronic Diseases Research Center of the NOVA Medical School (UNL-NMS-CEDOC) aims to be at the forefront of European and international scientific excellence in chronic RDs. Towards this goal, UNL-NMS-CEDOC is twinning with two internationally leading research institutions, the Münster University (WWU) and the Telethon Institute of Genetics and Medicine (TIGEM - FTELE.IGM). LYSOCIL will leverage on WWU and TIGEM’s outstanding multidisciplinary knowledge and experience, research and training best practices, as well as collaborative networks to enhance the research capacity and innovation potential of CEDOC-NMS. LYSOCIL is an integrated network of interactions (exchange and training of researchers, satellite meetings, Winter Retreats, virtual think tanks, etc.), articulated with the individual and joint scientific agendas of the partners, to power the research capacity of CEDOC-NMS and of its local and national ecosystems. LYSOCIL expects to increase by 20% in multiple indicators by 2021, including the number of citations; h-index of UNL-NMS-CEDOC researchers; percentage of publications in top impact journals; number of international collaborations and publications. By stimulating novel and long-lasting interactions between UNL-NMS-CEDOC, WWU and TIGEM (FTELE.GM) l unlock the research potential within and outside CEDOC-NMS, with an overall increase in the Portuguese and European RD research competitiveness.


year authors and title journal last update
List of publications.
2019 Carole Oudot, Andreia Gomes, Valérie Nicolas, Morgane Le Gall, Philippe Chaffey, Cédric Broussard, Giuseppe Calamita, Maria Mastrodonato, Patrizia Gena, Jean-Luc Perfettini, Jocelyne Hamelin, Antoinette Lemoine, Rodolphe Fischmeister, Helena L.A. Vieira, Claudia N. Santos, Catherine Brenner
CSRP3 mediates polyphenols-induced cardioprotection in hypertension
published pages: 29-42, ISSN: 0955-2863, DOI: 10.1016/j.jnutbio.2019.01.001
The Journal of Nutritional Biochemistry 66 2020-04-01
2019 David J. Smith, Thomas D. Montenegro-Johnson, Susana S. Lopes
Symmetry-Breaking Cilia-Driven Flow in Embryogenesis
published pages: 105-128, ISSN: 0066-4189, DOI: 10.1146/annurev-fluid-010518-040231
Annual Review of Fluid Mechanics 51/1 2020-04-01
2019 Martin D. Burkhalter, Arthi Sridhar, Pedro Sampaio, Raquel Jacinto, Martina S. Burczyk, Cornelia Donow, Max Angenendt, Maja Hempel, Paul Walther, Petra Pennekamp, Heymut Omran, Susana S. Lopes, Stephanie M. Ware, Melanie Philipp
Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis
published pages: 2841-2855, ISSN: 0021-9738, DOI: 10.1172/jci98890
Journal of Clinical Investigation 129/7 2020-04-01
2019 Daniel Noronha Osório, Ricardo Viana-Soares, João Pedro Marto, Marcelo D. Mendonça, Hugo P. Silva, Cláudia Quaresma, Miguel Viana-Baptista, Hugo Gamboa, Helena L. A. Vieira
Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
published pages: , ISSN: 1471-2261, DOI: 10.1186/s12872-019-1181-5
BMC Cardiovascular Disorders 19/1 2020-04-01
2019 Cláudia Figueiredo-Pereira, Regina Menezes, Sofia Ferreira, Cláudia N Santos, Helena L A Vieira
Carbon monoxide released by CORM-A1 prevents yeast cell death via autophagy stimulation
published pages: , ISSN: 1567-1364, DOI: 10.1093/femsyr/foz051
FEMS Yeast Research 19/5 2020-04-01
2019 Paolo Sanzà, Richard D. Evans, Deborah A. Briggs, Marta Cantero, Lluis Montoliu, Shyamal Patel, Elena V. Sviderskaya, Aymelt Itzen, Ana C. Figueiredo, Miguel C. Seabra, Alistair N. Hume
Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a
published pages: jcs212035, ISSN: 0021-9533, DOI: 10.1242/jcs.212035
Journal of Cell Science 132/9 2020-04-01
2019 Mahmoud R. Fassad, Mitali P. Patel, Amelia Shoemark, Thomas Cullup, Jane Hayward, Mellisa Dixon, Andrew V. Rogers, Sarah Ollosson, Claire Jackson, Patricia Goggin, Robert A. Hirst, Andrew Rutman, James Thompson, Lucy Jenkins, Paul Aurora, Eduardo Moya, Philip Chetcuti, Chris O\'Callaghan, Deborah J Morris-Rosendahl, Christopher M. Watson, Robert Wilson, Siobhan Carr, Woolf Walker, Andreia Pitno, Su
Clinical utility of NGS diagnosis and disease stratification in a multiethnic primary ciliary dyskinesia cohort
published pages: jmedgenet-2019-1, ISSN: 0022-2593, DOI: 10.1136/jmedgenet-2019-106501
Journal of Medical Genetics 2020-04-01
2019 Matthew J. Hayes, Thomas Burgoyne, Silene T. Wavre-Shapton, Tanya Tolmachova, Miguel C. Seabra, Clare E. Futter
Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease
published pages: 2515, ISSN: 1552-5783, DOI: 10.1167/iovs.19-26784
Investigative Opthalmology & Visual Science 60/7 2020-04-01
2019 Stefanie Kuhns, Cecília Seixas, Sara Pestana, Bárbara Tavares, Renata Nogueira, Raquel Jacinto, José S Ramalho, Jeremy C Simpson, Jens S Andersen, Arnaud Echard, Susana S Lopes, Duarte C Barral, Oliver E Blacque
Rab35 controls cilium length, function and membrane composition
published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201847625
EMBO reports 20/10 2020-04-01
2019 Hugo Moreiras, Francisco J. C. Pereira, Matilde V. Neto, Liliana Bento‐Lopes, Tiago C. Festas, Miguel C. Seabra, Duarte C. Barral
The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes
published pages: 366-371, ISSN: 1755-1471, DOI: 10.1111/pcmr.12840
Pigment Cell & Melanoma Research 33/2 2020-04-01
2019 Elisabeth M. Storck, Julia Morales-Sanfrutos, Remigiusz A. Serwa, Nattawadee Panyain, Thomas Lanyon-Hogg, Tanya Tolmachova, Leandro N. Ventimiglia, Juan Martin-Serrano, Miguel C. Seabra, Beata Wojciak-Stothard, Edward W. Tate
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics
published pages: 552-561, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0237-6
Nature Chemistry 11/6 2020-04-01
2019 Cristina Casalou, Alexandra Faustino, Fernanda Silva, Inês C. Ferreira, Daniela Vaqueirinho, Andreia Ferreira, Pedro Castanheira, Teresa Barona, José S. Ramalho, Jacinta Serpa, Ana Félix, Duarte C. Barral
Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling
published pages: 1461, ISSN: 2072-6694, DOI: 10.3390/cancers11101461
Cancers 11/10 2020-04-01
2019 Hugo Moreiras, Mafalda Lopes‐da‐Silva, Miguel C. Seabra, Duarte C. Barral
Melanin processing by keratinocytes: A non‐microbial type of host‐pathogen interaction?
published pages: 301-304, ISSN: 1398-9219, DOI: 10.1111/tra.12638
Traffic 20/4 2020-04-01
2015 Cláudia S F Queiroga, Alessandro Vercelli, Helena L A Vieira
Carbon monoxide and the CNS: challenges and achievements
published pages: 1533-1545, ISSN: 0007-1188, DOI: 10.1111/bph.12729
British Journal of Pharmacology 172/6 2019-05-23
2015 Sara R. Oliveira, Helena L.A. Vieira, Carlos B. Duarte
Effect of carbon monoxide on gene expression in cerebrocortical astrocytes: Validation of reference genes for quantitative real-time PCR
published pages: 80-89, ISSN: 1089-8603, DOI: 10.1016/j.niox.2015.07.003
Nitric Oxide 49 2019-05-23
2015 Ana S. Almeida, Cláudia Figueiredo-Pereira, Helena L. A. Vieira
Carbon monoxide and mitochondria – modulation of cell metabolism, redox response and cell death
published pages: , ISSN: 1664-042X, DOI:
Frontiers in Physiology 6 2019-05-23
2015 Sara R. Oliveira, Cláudia S. F. Queiroga, Helena L. A. Vieira
Mitochondria and carbon monoxide: cytoprotection and control of cell metabolism - a role for Ca2+?
published pages: , ISSN: 0022-3751, DOI:
The Journal of Physiology 2019-05-23
2015 Thomas Burgoyne, Ingrid P. Meschede, Jemima J. Burden, Maryse Bailly, Miguel C. Seabra, Clare E. Futter
Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment
published pages: 15922-15927, ISSN: 0027-8424, DOI: 10.1073/pnas.1509285113
Proceedings of the National Academy of Sciences 112/52 2019-05-03
2016 Otilia V. Vieira
Rab3a and Rab10 are regulators of lysosome exocytosis and plasma membrane repair
published pages: 349-351, ISSN: 2154-1248, DOI: 10.1080/21541248.2016.1235004
Small GTPases 9/4 2019-05-03
2018 Nanna Dreyer-Andersen, Ana Sofia Almeida, Pia Jensen, Morad Kamand, Justyna Okarmus, Tine Rosenberg, Stig Düring Friis, Alberto Martínez Serrano, Morten Blaabjerg, Bjarne Winther Kristensen, Troels Skrydstrup, Jan Bert Gramsbergen, Helena L. A. Vieira, Morten Meyer
Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells
published pages: e0191207, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0191207
PLOS ONE 13/1 2019-05-03
2018 Mark S. Gibson, Neuza Domingues, Otilia V. Vieira
Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00654
Frontiers in Physiology 9 2019-05-03
2018 Rita Gorgulho, Raquel Jacinto, Susana S. Lopes, Sofia A. Pereira, Erin M. Tranfield, Gabriel G. Martins, Emilio J. Gualda, Rico J. E. Derks, Ana C. Correia, Evelyne Steenvoorden, Petra Pintado, Oleg A. Mayboroda, Emilia C. Monteiro, Judit Morello
Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations
published pages: 411-423, ISSN: 0340-5761, DOI: 10.1007/s00204-017-2063-1
Archives of Toxicology 92/1 2019-05-03
2017 Florent Ubelmann, Tatiana Burrinha, Laura Salavessa, Ricardo Gomes, Cláudio Ferreira, Nuno Moreno, Cláudia Guimas Almeida
Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid
published pages: 102-122, ISSN: 1469-221X, DOI: 10.15252/embr.201642738
EMBO reports 18/1 2019-05-03
2018 Mathias J. Gerl, Winchil L. C. Vaz, Neuza Domingues, Christian Klose, Michal A. Surma, Júlio L. Sampaio, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo-Gonçalves, Jorge Ferreira, Claudia Borbinha, João Pedro Marto, Miguel Viana-Baptista, Kai Simons, Otilia V. Vieira
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-33116-4
Scientific Reports 8/1 2019-05-03
2018 Judit Morello, Rico J. E. Derks, Susana S. Lopes, Evelyne Steenvoorden, Emilia C. Monteiro, Oleg A. Mayboroda, Sofia A. Pereira
Zebrafish Larvae Are a Suitable Model to Investigate the Metabolic Phenotype of Drug-Induced Renal Tubular Injury
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.01193
Frontiers in Pharmacology 9 2019-05-03
2018 Sandra I. Anjo, Tania Martins-Marques, Paulo Pereira, Henrique Girão, Bruno Manadas
Elucidation of the dynamic nature of interactome networks: A practical tutorial
published pages: 116-126, ISSN: 1874-3919, DOI: 10.1016/j.jprot.2017.04.011
Journal of Proteomics 171 2019-05-03
2017 Florent Ubelmann, Tatiana Burrinha, Cláudia Guimas Almeida
A Novel Protocol to Quantitatively Measure the Endocytic Trafficking of Amyloid Precursor Protein (APP) in Polarized Primary Neurons with Sub-cellular Resolution
published pages: , ISSN: 2331-8325, DOI: 10.21769/BioProtoc.2629
BIO-PROTOCOL 7/23 2019-05-03
2017 Steve Catarino, Paulo Pereira, Henrique Girão
Molecular control of chaperone-mediated autophagy
published pages: 663-674, ISSN: 0071-1365, DOI: 10.1042/EBC20170057
Essays In Biochemistry 61/6 2019-05-03
2017 Ana Rita Ramalho, Adriana Toscano, Paulo Pereira, Henrique Girão, Lino Gonçalves, Carla Marques
Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia
published pages: 367-373, ISSN: 0870-2551, DOI: 10.1016/j.repc.2016.09.018
Revista Portuguesa de Cardiologia 36/5 2019-05-03
2018 Bettina Winckler, Victor Faundez, Sandra Maday, Qian Cai, Cláudia Guimas Almeida, Huaye Zhang
The Endolysosomal System and Proteostasis: From Development to Degeneration
published pages: 9364-9374, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.1665-18.2018
The Journal of Neuroscience 38/44 2019-05-03
2018 Sara R. Oliveira, Cláudia Figueiredo-Pereira, Carlos B. Duarte, Helena L. A. Vieira
P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes—Transcriptomic Study
published pages: , ISSN: 0893-7648, DOI: 10.1007/s12035-018-1302-7
Molecular Neurobiology 2019-05-03
2017 P. Pintado, P. Sampaio, B. Tavares, T. D. Montenegro-Johnson, D. J. Smith, S. S. Lopes
Dynamics of cilia length in left–right development
published pages: 161102, ISSN: 2054-5703, DOI: 10.1098/rsos.161102
Royal Society Open Science 4/3 2019-05-03
2018 Claudia N. Santos, Andreia Gomes, Carole Oudot, Daniela Dias-Pedroso, Ana Rodriguez-Mateos, Helena L.A. Vieira, Catherine Brenner
Pure Polyphenols Applications for Cardiac Health and Disease
published pages: 2137-2156, ISSN: 1381-6128, DOI: 10.2174/1381612824666180608102344
Current Pharmaceutical Design 24/19 2019-05-03
2017 Florent Ubelmann, Tatiana Burrinha, Cláudia Guimas Almeida
Measuring the Endocytic Recycling of Amyloid Precursor Protein (APP) in Neuro2a Cells
published pages: , ISSN: 2331-8325, DOI: 10.21769/BioProtoc.2635
BIO-PROTOCOL 7/23 2019-05-03
2018 Elsa Seixas, Cristina Escrevente, Miguel C. Seabra, Duarte C. Barral
Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31171-5
Scientific Reports 8/1 2019-05-03
2018 Cláudia Guimas Almeida, Farzaneh Sadat Mirfakhar, Catarina Perdigão, Tatiana Burrinha
Impact of late-onset Alzheimer’s genetic risk factors on beta-amyloid endocytic production
published pages: 2577-2589, ISSN: 1420-682X, DOI: 10.1007/s00018-018-2825-9
Cellular and Molecular Life Sciences 75/14 2019-05-03
2017 Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling, Ian Henry, Leonor Saúde, Susana Santos Lopes
Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.25165
eLife 6 2019-05-03
2018 Ioannis S. Dimopoulos, Stephanie C. Hoang, Alina Radziwon, Natalia M. Binczyk, Miguel C. Seabra, Robert E. MacLaren, Rizwan Somani, Matthew T.S. Tennant, Ian M. MacDonald
Two-Year Results After AAV2-Mediated Gene Therapy for Choroideremia: The Alberta Experience
published pages: 130-142, ISSN: 0002-9394, DOI: 10.1016/j.ajo.2018.06.011
American Journal of Ophthalmology 193 2019-05-03
2015 Tânia Martins-Marques, Steve Catarino, Carla Marques, Paulo Pereira, Henrique Girão
To beat or not to beat: degradation of Cx43 imposes the heart rhythm
published pages: , ISSN: 0300-5127, DOI:
Biochemical Society transactions 2019-05-03
2018 Kanmin Xue, Jasleen K Jolly, Alun R. Barnard, Anna Rudenko, Anna P. Salvetti, Maria I. Patrício, Thomas L. Edwards, Markus Groppe, Harry O. Orlans, Tanya Tolmachova, Graeme C. Black, Andrew R. Webster, Andrew J. Lotery, Graham E. Holder, Susan M. Downes, Miguel C. Seabra, Robert E. MacLaren
Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia
published pages: 1507-1512, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0185-5
Nature Medicine 24/10 2019-05-03
2018 Ana S. Almeida, Nuno L. Soares, Catarina O. Sequeira, Sofia A. Pereira, Ursula Sonnewald, Helena L.A. Vieira
Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway
published pages: 338-347, ISSN: 2213-2317, DOI: 10.1016/j.redox.2018.05.004
Redox Biology 17 2019-05-03
2017 Rui Baptista, Carla Marques, Steve Catarino, Francisco J Enguita, Marina C Costa, Paulo Matafome, Mónica Zuzarte, Graça Castro, Abílio Reis, Pedro Monteiro, Mariano Pêgo, Paulo Pereira, Henrique Girão
MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1
published pages: 53-64, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx187
Cardiovascular Research 114/1 2019-05-03
2015 Silène T. Wavre-Shapton, Alessandra A. Calvi, Mark Turmaine, Miguel C. Seabra, Daniel F. Cutler, Clare E. Futter, Hannah M. Mitchison
Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).
published pages: , ISSN: 0964-6906, DOI:
Human Molecular Genetics 2019-05-03
2018 Daniela Dias-Pedroso, Joel Guerra, Andreia Gomes, Carole Oudot, Catherine Brenner, Cláudia N. Santos, Helena L. A. Vieira
Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol
published pages: , ISSN: 1530-7905, DOI: 10.1007/s12012-018-9485-8
Cardiovascular Toxicology 2019-05-03
2019 J. Solowiej-Wedderburn, D.J. Smith, S.S. Lopes, T.D. Montenegro-Johnson
Wall stress enhanced exocytosis of extracellular vesicles as a possible mechanism of left-right symmetry-breaking in vertebrate development
published pages: 220-226, ISSN: 0022-5193, DOI: 10.1016/j.jtbi.2018.10.015
Journal of Theoretical Biology 460 2019-05-03
2016 Tania Martins-Marques, Maria Joao Pinho, Monica Zuzarte, Carla Oliveira, Paulo Pereira, Joost P. G. Sluijter, Celia Gomes, Henrique Girao
Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin
published pages: 32538, ISSN: 2001-3078, DOI: 10.3402/jev.v5.32538
Journal of Extracellular Vesicles 5/1 2019-05-03
2015 Marta Mauro-Lizcano, Lorena Esteban-Martínez, Esther Seco, Ana Serrano-Puebla, Lucia Garcia-Ledo, Cláudia Figueiredo-Pereira, Helena L A Vieira, Patricia Boya
New method to assess mitophagy flux by flow cytometry
published pages: 833-843, ISSN: 1554-8627, DOI: 10.1080/15548627.2015.1034403
Autophagy 11/5 2019-05-03
2018 Maria S. Correia, Hugo Moreiras, Francisco J.C. Pereira, Matilde V. Neto, Tiago C. Festas, Abul K. Tarafder, José S. Ramalho, Miguel C. Seabra, Duarte C. Barral
Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments
published pages: 637-646, ISSN: 0022-202X, DOI: 10.1016/j.jid.2017.09.042
Journal of Investigative Dermatology 138/3 2019-05-03
2015 Carolina Thieleke‐Matos, Mafalda Lopes da Silva, Laura Cabrita‐Santos, Martim D. Portal, Inês P. Rodrigues, Vanessa Zuzarte‐Luis, José S. Ramalho, Clare E. Futter, Maria M. Mota, Duarte C. Barral, Miguel C. Seabra
Host cell autophagy contributes to Plasmodium liver development
published pages: , ISSN: 1462-5814, DOI:
Cellular Microbiology 2019-05-03
2016 Ângela S. Inácio, Neuza S. Domingues, Alexandra Nunes, Patrícia T. Martins, Maria J. Moreno, Luís M. Estronca, Rui Fernandes, António J. M. Moreno, Maria J. Borrego, João P. Gomes, Winchil L. C. Vaz, Otília V. Vieira
Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: mechanisms of action and clinical implications in antibacterial prophylaxis
published pages: 641-654, ISSN: 0305-7453, DOI: 10.1093/jac/dkv405
Journal of Antimicrobial Chemotherapy 71/3 2019-05-03
2016 Marisa Encarnação, Lília Espada, Cristina Escrevente, Denisa Mateus, José Ramalho, Xavier Michelet, Inês Santarino, Victor W. Hsu, Michael B. Brenner, Duarte C. Barral, Otília V. Vieira
A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair
published pages: 631-640, ISSN: 0021-9525, DOI: 10.1083/jcb.201511093
The Journal of Cell Biology 213/6 2019-05-03
2016 Bret Wankel, Jiangyong Ouyang, Xuemei Guo, Krassimira Hadjiolova, Jeremy Miller, Yi Liao, Daniel Kai Long Tham, Rok Romih, Leonardo R. Andrade, Iwona Gumper, Jean-Pierre Simon, Rakhee Sachdeva, Tanya Tolmachova, Miguel C. Seabra, Mitsunori Fukuda, Nicole Schaeren-Wiemers, Wan Jin Hong, David D. Sabatini, Xue-Ru Wu, Xiangpeng Kong, Gert Kreibich, Michael J. Rindler, Tung-Tien Sun
Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells
published pages: 1621-1634, ISSN: 1059-1524, DOI: 10.1091/mbc.E15-04-0230
Molecular Biology of the Cell 27/10 2019-05-03
2016 Ângela S. Inácio, Alexandra Nunes, Catarina Milho, Luís Jaime Mota, Maria J. Borrego, João P. Gomes, Winchil L. C. Vaz, Otília V. Vieira
In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents
published pages: , ISSN: 0066-4804, DOI:
Antimicrobial agents and chemotherapy 2019-05-03
2016 Susana A. Gonçalves, Diana Macedo, Helena Raquel, Pedro D. Simões, Flaviano Giorgini, José S. Ramalho, Duarte C. Barral, Luís Ferreira Moita, Tiago Fleming Outeiro
shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity
published pages: e1005995, ISSN: 1553-7390, DOI: 10.1371/journal.pgen.1005995
PLOS Genetics 12/4 2019-05-03
2015 B. Walker, E. Schmid, A. Russo, E.-M. Schmidt, O. Burk, P. Münzer, A. Velic, B. Macek, M. Schaller, M. Schwab, M. C. Seabra, M. Gawaz, F. Lang, O. Borst
Impact of the serum- and glucocorticoid-inducible kinase 1 on platelet dense granule biogenesis and secretion
published pages: 1325-1334, ISSN: 1538-7933, DOI: 10.1111/jth.12998
Journal of Thrombosis and Haemostasis 13/7 2019-05-03
2015 Margaret Alexander, Ruozhen Hu, Marah C. Runtsch, Dominique A. Kagele, Timothy L. Mosbruger, Tanya Tolmachova, Miguel C. Seabra, June L. Round, Diane M. Ward, Ryan M. O’Connell
Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
published pages: , ISSN: 2041-1723, DOI: 10.1038/ncomms8321
Nature Communications 6/1 2019-05-03
2015 Nadine Reichhart, Magdalena Markowski, Shimpei Ishiyama, Andrea Wagner, Sergio Crespo-Garcia, Talitha Schorb, José S. Ramalho, Vladimir M. Milenkovic, Renate Föckler, Miguel C. Seabra, Olaf Strauß
Rab27a GTPase modulates L-type Ca(2+) channel function via interaction with the II-III linker of CaV1.3 subunit.
published pages: , ISSN: 0898-6568, DOI:
Cellular Signalling 2019-05-03
2015 T. Burgoyne, M. N. O\'Connor, M. C. Seabra, D. F. Cutler, C. E. Futter
Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL
published pages: 1400-1407, ISSN: 0021-9533, DOI: 10.1242/jcs.164400
Journal of Cell Science 128/7 2019-05-03
2016 Cristina Casalou, Alexandra Faustino, Duarte C. Barral
Arf proteins in cancer cell migration
published pages: 270-282, ISSN: 2154-1248, DOI: 10.1080/21541248.2016.1228792
Small GTPases 7/4 2019-05-03
2016 Thomas L. Edwards, Jasleen K. Jolly, Markus Groppe, Alun R. Barnard, Charles L. Cottriall, Tanya Tolmachova, Graeme C. Black, Andrew R. Webster, Andrew J. Lotery, Graham E. Holder, Kanmin Xue, Susan M. Downes, Matthew P. Simunovic, Miguel C. Seabra, Robert E. MacLaren
Visual Acuity after Retinal Gene Therapy for Choroideremia
published pages: 1996-1998, ISSN: 0028-4793, DOI: 10.1056/NEJMc1509501
New England Journal of Medicine 374/20 2019-05-03
2016 Ana S. Almeida, Nuno L. Soares, Melissa Vieira, Jan Bert Gramsbergen, Helena L. A. Vieira
Carbon Monoxide Releasing Molecule-A1 (CORM-A1) Improves Neurogenesis: Increase of Neuronal Differentiation Yield by Preventing Cell Death
published pages: e0154781, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0154781
PLOS ONE 11/5 2019-05-03
2016 Daniela Pedroso, Ana R. Nunes, Lucília N. Diogo, Carole Oudot, Emília C. Monteiro, Catherine Brenner, Helena L.A. Vieira
Hippocampal neurogenesis response: What can we expect from two different models of hypertension?
published pages: 199-206, ISSN: 0006-8993, DOI: 10.1016/j.brainres.2016.05.044
Brain Research 1646 2019-05-03
2015 Quanlong Lu, Christine Insinna, Carolyn Ott, Jimmy Stauffer, Petra A. Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo-Seok Hwang, Ira O. Daar, Susana Lopes, Jennifer Lippincott-Schwartz, Peter K. Jackson, Steve Caplan, Christopher J. Westlake
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation
published pages: 228-240, ISSN: 1465-7392, DOI: 10.1038/ncb3109
Nature Cell Biology 17/3 2019-05-03
2015 Tânia Martins-Marques, Steve Catarino, Carla Marques, Paulo Matafome, Teresa Ribeiro-Rodrigues, Rui Baptista, Paulo Pereira, Henrique Girão
Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs
published pages: 196-201, ISSN: 0300-9084, DOI: 10.1016/j.biochi.2015.02.020
Biochimie 112 2019-05-03
2016 Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, Slimane Ait-Si-Ali, Takahiko Akematsu, Emmanuel T Akporiaye, Mohamed Al-Rubeai, Guillermo M Albaiceta, Chris Albanese, Diego Albani, Matthew L Albert, Jesus Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte-Beceril, Emad S Alnemri, Covadonga Alonso, Nihal Altan-Bonnet, Dario C Altieri, Silvia Alvarez, Lydia Alvarez-Erviti, Sandro Alves, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A Anania, Stig U Andersen, Usha P Andley, Catherine K Andreadi, Nathalie Andrieu-Abadie, Alberto Anel, David K Ann, Shailendra Anoopkumar-Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustin Aranda, Jun Araya, Alexandre Arcaro, Esperanza Arias, Hirokazu Arimoto, Aileen R Ariosa, Jane L Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askanas, Eric Asselin, Ryuichiro Atarashi, Sally S Atherton, Julie D Atkin, Laura D Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan M Backer, Dong-Hun Bae, Jae-sung Bae, Ok-Nam Bae, Soo Han Bae, Eric H Baehrecke, Seung-Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xue-Yuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rajkumar Banerjee, Gábor Bánhegyi, Haijun Bao, Benoit Barbeau, Maria D Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C Bassham, Maria Teresa Bassi, Robert C Bast, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle Bauckman, Bradley L Baumgarner, K Ulrich Bayer, Rupert Beale, Jean-François Beaulieu, George R. Beck, Christoph Becker, J David Beckham, Pierre-André Bédard, Patrick J Bednarski, Thomas J Begley, Christian Behl, Christian Behrends, Georg MN Behrens, Kevin E Behrns, Eloy Bejarano, Amine Belaid, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S Bess, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard-Piechaczyk, Viktor Billes, Claudia Bincoletto, Baris Bingol, Sara W Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo A Blanco, Heidi Kiil Blomhoff, Emilio Boada-Romero, Stefan Böckler, Marianne Boes, Kathleen Boesze-Battaglia, Lawrence H Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luis M Botana, Joelle Botti, German Bou, Marina Bouché, Marion Bouchecareilh, Marie-Josée Boucher, Michael E Boulton, Sebastien G Bouret, Patricia Boya, Michaël Boyer-Guittaut, Peter V Bozhkov, Nathan Brady, Vania MM Braga, Claudio Brancolini, Gerhard H Braus, José M Bravo-San Pedro, Lisa A Brennan, Emery H Bresnick, Patrick Brest, Dave Bridges, Marie-Agnès Bringer, Marisa Brini, Glauber C Brito, Bertha Brodin, Paul S Brookes, Eric J Brown, Karen Brown, Hal E Broxmeyer, Alain Bruhat, Patricia Chakur Brum, John H Brumell, Nicola Brunetti-Pierri, Robert J Bryson-Richardson, Shilpa Buch, Alastair M Buchan, Hikmet Budak, Dmitry V Bulavin, Scott J Bultman, Geert Bultynck, Vladimir Bumbasirevic, Yan Burelle, Robert E Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahova, Dongsheng Cai, Jingjing Cai, Qian Cai, Sara Calatayud,
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
published pages: 1-222, ISSN: 1554-8627, DOI: 10.1080/15548627.2015.1100356
Autophagy 12/1 2019-05-03
2017 Inês B. Santarino, Otília V. Vieira
Maturation of phagosomes containing different erythrophagocytic particles in primary macrophages
published pages: 1281-1290, ISSN: 2211-5463, DOI: 10.1002/2211-5463.12262
FEBS Open Bio 7/9 2019-05-03
2016 João Carlos Ribeiro, Bárbara Oliveiros, Paulo Pereira, Natália António, Thomas Hummel, António Paiva, Eduardo D. Silva
Accelerated age-related olfactory decline among type 1 Usher patients
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep28309
Scientific Reports 6/1 2019-05-03
2017 Inês B. Santarino, Michelle S. Viegas, Neuza S. Domingues, Ana M. Ribeiro, Miguel P. Soares, Otília V. Vieira
Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05687-1
Scientific Reports 7/1 2019-05-03
2017 Teresa M. Ribeiro-Rodrigues, Tiago L. Laundos, Rita Pereira-Carvalho, Daniela Batista-Almeida, Ricardo Pereira, Vanessa Coelho-Santos, Ana P. Silva, Rosa Fernandes, Monica Zuzarte, Francisco J. Enguita, Marina C. Costa, Perpetua Pinto-do-Ó, Marta T. Pinto, Pedro Gouveia, Lino Ferreira, Justin C. Mason, Paulo Pereira, Brenda R. Kwak, Diana S. Nascimento, Henrique Girão
Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis
published pages: 1338-1350, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx118
Cardiovascular Research 113/11 2019-05-03
2017 Neuza Domingues, Luís M.B.B. Estronca, João Silva, Marisa R. Encarnação, Rita Mateus, Diogo Silva, Inês B. Santarino, Margarida Saraiva, Maria I.L. Soares, Teresa M.V.D. Pinho e Melo, António Jacinto, Winchil L.C. Vaz, Otília V. Vieira
Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages
published pages: 210-220, ISSN: 1388-1981, DOI: 10.1016/j.bbalip.2016.10.009
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862/2 2019-05-03
2016 Cecília Seixas, Soo Young Choi, Noemi Polgar, Nicole L. Umberger, Michael P. East, Xiaofeng Zuo, Hugo Moreiras, Rania Ghossoub, Alexandre Benmerah, Richard A. Kahn, Ben Fogelgren, Tamara Caspary, Joshua H. Lipschutz, Duarte C. Barral
Arl13b and the exocyst interact synergistically in ciliogenesis
published pages: 308-320, ISSN: 1059-1524, DOI: 10.1091/mbc.E15-02-0061
Molecular Biology of the Cell 27/2 2019-05-03
2017 Jayne Louise Wilson, Frédéric Bouillaud, Ana S. Almeida, Helena L. Vieira, Mohand Ouidir Ouidja, Jean-Luc Dubois-Randé, Roberta Foresti, Roberto Motterlini
Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus
published pages: 311-323, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2017.01.022
Free Radical Biology and Medicine 104 2019-05-03
2016 Ana S. Almeida, Ursula Sonnewald, Paula M. Alves, Helena L.A. Vieira
Carbon monoxide improves neuronal differentiation and yield by increasing the functioning and number of mitochondria
published pages: 423-435, ISSN: 0022-3042, DOI: 10.1111/jnc.13653
Journal of Neurochemistry 138/3 2019-05-03
2015 Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Paulo Pereira, Patrice Codogno, Henrique Girao
Autophagy and Ubiquitination in Cardiovascular Diseases
published pages: 243-251, ISSN: 1044-5498, DOI: 10.1089/dna.2014.2765
DNA and Cell Biology 34/4 2019-05-03
2015 Joao Vasco Ferreira, Ana Rosa Soares, Jose Silva Ramalho, Paulo Pereira, Henrique Girao
K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep10210
Scientific Reports 5/1 2019-05-03
2015 Teresa M. Ribeiro-Rodrigues, Steve Catarino, Maria J. Pinho, Paulo Pereira, Henrique Girao
Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive
published pages: , ISSN: 0300-5127, DOI:
Biochemical Society transactions 2019-05-03
2017 João T. Proença, Duarte C. Barral, Isabel Gordo
Commensal-to-pathogen transition: One-single transposon insertion results in two pathoadaptive traits in Escherichia coli -macrophage interaction
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-04081-1
Scientific Reports 7/1 2019-05-03
2017 Margaret Alexander, Andrew G. Ramstead, Kaylyn M. Bauer, Soh-Hyun Lee, Marah C. Runtsch, Jared Wallace, Thomas B. Huffaker, Dane K. Larsen, Tanya Tolmachova, Miguel C. Seabra, June L. Round, Diane M. Ward, Ryan M. O’Connell
Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli
published pages: 3559-3570, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1700904
The Journal of Immunology 199/10 2019-05-03
2016 Susana S. Lopes, Martin Distel, Claudia Linker, Rita Fior, Rui Monteiro, Isaac H. Bianco, Ruben Portugues, Uwe Strähle, Leonor Saúde
Report of the 4th European Zebrafish Principal Investigator Meeting
published pages: 590-595, ISSN: 1545-8547, DOI: 10.1089/zeb.2016.1364
Zebrafish 13/6 2019-05-03
2015 Tania Martins-Marques, Steve Catarino, Monica Zuzarte, Carla Marques, Paulo Matafome, Paulo Pereira, Henrique Girão
Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes
published pages: 231-245, ISSN: 0264-6021, DOI: 10.1042/BJ20141370
Biochemical Journal 467/2 2019-05-03
2015 M. Roxo-Rosa, R. Jacinto, P. Sampaio, S. S. Lopes
The zebrafish Kupffer\'s vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR
published pages: 1356-1366, ISSN: 2046-6390, DOI: 10.1242/bio.014076
Biology Open 4/11 2019-05-03
2017 Z. Wang, C. Figueiredo-Pereira, C. Oudot, H.L.A. Vieira, C. Brenner
Mitochondrion: a common organelle for distinct cell deaths?
published pages: , ISSN: 1937-6448, DOI:
International review of cell and molecular biology 2019-05-03
2016 T. D. Montenegro-Johnson, D. I. Baker, D. J. Smith, S. S. Lopes
Three-dimensional flow in Kupffer’s Vesicle
published pages: 705-725, ISSN: 0303-6812, DOI: 10.1007/s00285-016-0967-7
Journal of Mathematical Biology 73/3 2019-05-03
2017 Ana S. Almeida, Helena L. A. Vieira
Role of Cell Metabolism and Mitochondrial Function During Adult Neurogenesis
published pages: 1787-1794, ISSN: 0364-3190, DOI: 10.1007/s11064-016-2150-3
Neurochemical Research 42/6 2019-05-03
2015 Ana Silva, Luana Naia, Alejandro Dominguez, Márcio Ribeiro, Joana Rodrigues, Otília V. Vieira, Volkmar Lessmann, Ana Cristina Rego
Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington\'s Disease
published pages: 207-218, ISSN: 1660-2854, DOI: 10.1159/000375447
Neurodegenerative Diseases 15/4 2019-05-03
2015 Ana Rosa Soares, Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Joao Vasco Ferreira, Steve Catarino, Maria João Pinho, Monica Zuzarte, Sandra Isabel Anjo, Bruno Manadas, Joost P.G. Sluijter, Paulo Pereira, Henrique Girao
Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep13243
Scientific Reports 5/1 2019-05-03
2015 Tania Martins-Marques, Sandra Isabel Anjo, Paulo Pereira, Bruno Manadas, Henrique Girão
Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart
published pages: 3040-3055, ISSN: 1535-9476, DOI: 10.1074/mcp.M115.052894
Molecular & Cellular Proteomics 14/11 2019-05-03
2018 David J. Smith, Thomas D. Montenegro-Johnson, Susana S. Lopes
Symmetry-Breaking Cilia-Driven Flow in Embryogenesis
published pages: , ISSN: 0066-4189, DOI:
Annual Review of Fluid Mechanics 2019-02-12

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