Opendata, web and dolomites

ProtoMet SIGNED

Protometabolic pathways: exploring the chemical roots of systems biology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 ProtoMet project word cloud

Explore the words cloud of the ProtoMet project. It provides you a very rough idea of what is the project "ProtoMet" about.

reconstituted    coacervate    enter    structures    mimic    laboratories    microfluidic    gain    skills    record    big    catalysts    biology    tremendous    understanding    progress    positioned    underpinnings    life    triose    houses    chemistry    tools    protocellular    think    industry    acid    protometabolism    construction    glycolysis    formulations    exploited    prebiotic    coacervates    scientists    etched    compartments    molecules    esrs    absence    expertise    experts    citric    disciplines    metallodrug    vehicles    train    regulated    secondments    science    enduring    extremely    chips    ultimately    stage    eight    reverse    containing    vesicles    variety    similarly    medicinal    peptide    underlying    philosophy    logically    primarily    elucidating    synthetic    newfound    compartment    either    plan    greatest    academia    chemical    alongside    maintenance    drug    specializes    cycle    mysteries    generation    company    gave    metallo    historical    firsthand    microfluidics    living    methodically    complete    cells    consisting    secondment    colleagues    recruited    protocell   

Project "ProtoMet" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TRENTO 

Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122
website: www.unitn.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙174˙048 €
 EC max contribution 2˙174˙048 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 261˙499.00
2    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 303˙172.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 281˙276.00
4    CHERRY BIOTECH FR (RENNES) participant 274˙802.00
5    ELVESYS FR (PARIS) participant 274˙802.00
6    UNIVERSITE DE STRASBOURG FR (STRASBOURG) participant 274˙802.00
7    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 252˙788.00
8    UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA ES (LEIOA) participant 250˙904.00
9    KUTXAGESTION ZERBITZUAK S.L.U. ES (DONOSTIA - SAN SEBASTIAN) partner 0.00
10    METALLOPHARM LLC US (Delaware) partner 0.00
11    NANOVEX BIOTECHNOLOGIES SL ES (LLANERA) partner 0.00

Map

 Project objective

Understanding how prebiotic chemistry gave rise to life as we know it represents one of the greatest enduring mysteries. The complete absence of a historical record requires the collaboration of scientists from different disciplines with access to advanced tools in order to make any meaningful progress. Here, we plan to exploit this tremendous challenge to train a new generation of scientists to think big, but also to work methodically and logically alongside colleagues from academia and industry. Eight Early-Stage Researchers (ESRs) will be recruited to work in laboratories with expertise in systems chemistry, synthetic biology, microfluidics, and science philosophy to develop together a reconstituted protometabolism within compartments consisting of coacervates, vesicles, coacervate containing vesicles, and compartments etched into microfluidic chips. The underlying protometabolism will be composed of triose glycolysis and a reverse citric acid cycle and will be regulated by (metallo)peptide catalysts. Importantly, the protometabolism will support the maintenance of the compartment that houses the protocell. The ESRs that primarily focus on the construction of compartments that mimic protocellular structures will gain firsthand experience in how their formulations could be exploited as drug delivery vehicles through secondments at partner organizations. Similarly, the ESRs that develop (metallo)peptide catalysts will apply their newfound skills to the development of drug molecules through a secondment at a company that specializes in metallodrug formulations. Ultimately, by becoming experts in elucidating the chemical underpinnings of all known living cells, the ESRs will be extremely well positioned to enter a wide variety of research fields from synthetic biology to medicinal chemistry in either industry or academia.

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The information about "PROTOMET" are provided by the European Opendata Portal: CORDIS opendata.

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