Opendata, web and dolomites

OXIGENATED SIGNED

Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 OXIGENATED project word cloud

Explore the words cloud of the OXIGENATED project. It provides you a very rough idea of what is the project "OXIGENATED" about.

assembly    limited    argentina    surface    serum    chemistry    entrapped    emission    estonia    peptides    content    skills    albumin    pdt    transport    tissue    exchanging    exposed    actively    homing    treatment    modified    science    brazil    tomography    vivo    hemoglobin    toxicity    oxigenated    seconded    species    photosensitizing    forefront    networking    positron    radiolabeled    efficient    coating    molecules    tumour    fundamental    efficiency    gathered    complementary    simultaneous    photosensitizer    photodynamic    breast    generate    therapy    therapies    nano    hypoxia    mice    drawback    spain    scientists    skin    complexed    core    scientific    vitro    cells    germany    models    ros    thailand    co    bovine    tested    team    prepared    commercialization    molecular    single    delivered    stage    computer    imaging    submicron    intracellular    hobcs    carriers    oxygen    training    cancer    multidisciplinary    biology    secondments    self    sme    participation    ultimately    nanocarriers    drug    molecule    environments    material    malignant    causing    physics    fate    generation    carbonates    radical    precipitation    death   

Project "OXIGENATED" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 920˙000 €
 EC max contribution 920˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2018
 Funding Scheme MSCA-RISE
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 529˙000.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 211˙600.00
3    TARTU ULIKOOL EE (TARTU) participant 156˙400.00
4    Surflay Nanotec GmbH DE (BERLIN) participant 23˙000.00
5    CHULALONGKORN UNIVERSITY TH (BANGKOK) partner 0.00
6    FUNDACAO UNIVERSIDADE DE BRASILIA BR (BRASILIA DF) partner 0.00
7    UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN AR (SAN MARTIN BUENOS AIRES) partner 0.00
8    UNIVERSIDAD NACIONAL DEL SUR AR (BAHIA BLANCA) partner 0.00

Map

 Project objective

A major drawback of Photodynamic Therapy (PDT) and other therapies for cancer treatment is the limited oxygen content, hypoxia, in tumour tissue. In PDT a photosensitizing molecule is delivered to malignant tissue to generate radical oxygen species (ROS). The presence of oxygen is fundamental for ROS generation, ultimately causing the death of tumour cells. This project aims to develop hemoglobin drug delivery nanocarriers in the nano and submicron range for simultaneous oxygen and photosensitizer delivery to tumour tissue for a more efficient Photodynamic Therapy. Hemoglobin-based nanocarriers (HOBCs) will be prepared by co-precipitation of hemoglobin with carbonates and surface coating with bovine serum albumin. The carriers will transport oxygen complexed to hemoglobin while photosensitizer molecules will be entrapped in the core. Carriers will be modified with homing peptides to target them to cancer cells. In vitro studies will be conducted to study the uptake of HOBCs by cells, their intracellular fate, toxicity, and oxygen and photosensitizer delivery. In vivo fate of carriers will be studied in mice with radiolabeled carriers by Positron Emission Tomography and Single Emission Computer Tomography. The efficiency of the HOBCs for oxygen delivery and for PDT will be tested in vitro and in vivo in breast and skin cancer models. A multidisciplinary team has been gathered with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Imaging, Molecular Biology and Cancer Therapy from Germany, Estonia, Spain, Brazil, Argentina and Thailand. The participation of a SME will be fundamental for the future commercialization of project developments. OXIGENATED will actively work towards exchanging skills and knowledge through secondments of Early Stage and Experienced Researchers, and through networking and training activities. Seconded researchers will develop new scientific and complementary skills while exposed to new research environments.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "OXIGENATED" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "OXIGENATED" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.3.)

TREND (2019)

Transition with Resilience for Evolutionary Development

Read More  

aiD (2019)

aRTIFICIAL iNTELLIGENCE for the Deaf

Read More  

FUNGLASS (2019)

FUNctional GLASS

Read More