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OXIGENATED SIGNED

Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy

Total Cost €

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EC-Contrib. €

0

Partnership

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 OXIGENATED project word cloud

Explore the words cloud of the OXIGENATED project. It provides you a very rough idea of what is the project "OXIGENATED" about.

vivo    gathered    malignant    tomography    intracellular    efficiency    photosensitizing    positron    albumin    actively    transport    complementary    self    entrapped    cancer    vitro    exposed    stage    content    carbonates    co    tissue    serum    forefront    computer    commercialization    drawback    modified    limited    death    molecule    imaging    therapies    material    molecules    delivered    science    prepared    training    complexed    generation    breast    photodynamic    biology    models    multidisciplinary    precipitation    emission    peptides    homing    simultaneous    scientists    hemoglobin    physics    therapy    species    spain    cells    environments    molecular    hypoxia    causing    bovine    efficient    surface    oxygen    nanocarriers    generate    mice    skin    networking    radical    tumour    radiolabeled    sme    argentina    nano    hobcs    single    chemistry    carriers    estonia    drug    germany    treatment    ultimately    coating    oxigenated    pdt    skills    fate    assembly    tested    submicron    team    core    participation    secondments    seconded    toxicity    photosensitizer    fundamental    exchanging    ros    scientific    brazil    thailand   

Project "OXIGENATED" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 920˙000 €
 EC max contribution 920˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2018
 Funding Scheme MSCA-RISE
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 529˙000.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 211˙600.00
3    TARTU ULIKOOL EE (TARTU) participant 156˙400.00
4    Surflay Nanotec GmbH DE (BERLIN) participant 23˙000.00
5    CHULALONGKORN UNIVERSITY TH (BANGKOK) partner 0.00
6    FUNDACAO UNIVERSIDADE DE BRASILIA BR (BRASILIA DF) partner 0.00
7    UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN AR (SAN MARTIN BUENOS AIRES) partner 0.00
8    UNIVERSIDAD NACIONAL DEL SUR AR (BAHIA BLANCA) partner 0.00

Map

 Project objective

A major drawback of Photodynamic Therapy (PDT) and other therapies for cancer treatment is the limited oxygen content, hypoxia, in tumour tissue. In PDT a photosensitizing molecule is delivered to malignant tissue to generate radical oxygen species (ROS). The presence of oxygen is fundamental for ROS generation, ultimately causing the death of tumour cells. This project aims to develop hemoglobin drug delivery nanocarriers in the nano and submicron range for simultaneous oxygen and photosensitizer delivery to tumour tissue for a more efficient Photodynamic Therapy. Hemoglobin-based nanocarriers (HOBCs) will be prepared by co-precipitation of hemoglobin with carbonates and surface coating with bovine serum albumin. The carriers will transport oxygen complexed to hemoglobin while photosensitizer molecules will be entrapped in the core. Carriers will be modified with homing peptides to target them to cancer cells. In vitro studies will be conducted to study the uptake of HOBCs by cells, their intracellular fate, toxicity, and oxygen and photosensitizer delivery. In vivo fate of carriers will be studied in mice with radiolabeled carriers by Positron Emission Tomography and Single Emission Computer Tomography. The efficiency of the HOBCs for oxygen delivery and for PDT will be tested in vitro and in vivo in breast and skin cancer models. A multidisciplinary team has been gathered with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Imaging, Molecular Biology and Cancer Therapy from Germany, Estonia, Spain, Brazil, Argentina and Thailand. The participation of a SME will be fundamental for the future commercialization of project developments. OXIGENATED will actively work towards exchanging skills and knowledge through secondments of Early Stage and Experienced Researchers, and through networking and training activities. Seconded researchers will develop new scientific and complementary skills while exposed to new research environments.

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The information about "OXIGENATED" are provided by the European Opendata Portal: CORDIS opendata.

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