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OXIGENATED SIGNED

Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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OXIGENATED project word cloud

Explore the words cloud of the OXIGENATED project. It provides you a very rough idea of what is the project "OXIGENATED" about.

molecule nano death nanocarriers oxygen delivered computer positron science material molecular bovine hemoglobin tissue forefront photosensitizer serum photodynamic transport cells physics coating sme content modified co secondments gathered complementary carbonates actively tested albumin fate species drug networking intracellular pdt environments tomography single participation ros multidisciplinary efficient fundamental commercialization vitro radical hypoxia vivo treatment scientific hobcs cancer submicron simultaneous limited breast imaging thailand generate therapy models tumour oxigenated efficiency radiolabeled assembly therapies drawback causing ultimately chemistry emission brazil complexed homing entrapped germany self core carriers exposed malignant skills team molecules training biology stage mice scientists seconded toxicity peptides skin argentina estonia photosensitizing generation surface precipitation spain exchanging prepared

Project "OXIGENATED" data sheet

The following table provides information about the project.

Coordinator	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Organization address address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C city: SAN SEBASTIAN postcode: 20009 website: www.cicbiomagune.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	920˙000 €
EC max contribution	920˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2018
Funding Scheme	MSCA-RISE
Starting year	2019
Duration (year-month-day)	from 2019-03-01 to 2023-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Organization address address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C city: SAN SEBASTIAN postcode: 20009 website: www.cicbiomagune.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SAN SEBASTIAN)	coordinator	529˙000.00
2	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	211˙600.00
3	TARTU ULIKOOL TARTU ULIKOOL Organization address address: ULIKOOLI 18 city: TARTU postcode: 51005 website: www.ut.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	156˙400.00
4	Surflay Nanotec GmbH Surflay Nanotec GmbH Organization address address: MAX PLANCK STRASSE 3 city: BERLIN postcode: 12489 website: www.surflay.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	23˙000.00
5	CHULALONGKORN UNIVERSITY CHULALONGKORN UNIVERSITY Organization address address: PHYATHAI ROAD 254 PATHUMWAN city: BANGKOK postcode: 10330 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	TH (BANGKOK)	partner	0.00
6	FUNDACAO UNIVERSIDADE DE BRASILIA FUNDACAO UNIVERSIDADE DE BRASILIA Organization address address: CAMPUS UNIVERSITARIO DARCY RIBEIRO FACULDADE DE TECNOLOGIE AT 05 BAIRRO ASA NORTE city: BRASILIA DF postcode: 70919 970 website: www.unb.br contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BR (BRASILIA DF)	partner	0.00
7	UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN Organization address address: MARTIN DE IRIGOYEN 3100 city: SAN MARTIN BUENOS AIRES postcode: 1650 website: www.idaes.edu.ar contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (SAN MARTIN BUENOS AIRES)	partner	0.00
8	UNIVERSIDAD NACIONAL DEL SUR UNIVERSIDAD NACIONAL DEL SUR Organization address address: AVENIDA COLON 80 city: BAHIA BLANCA postcode: 8000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (BAHIA BLANCA)	partner	0.00

Map

Project objective

A major drawback of Photodynamic Therapy (PDT) and other therapies for cancer treatment is the limited oxygen content, hypoxia, in tumour tissue. In PDT a photosensitizing molecule is delivered to malignant tissue to generate radical oxygen species (ROS). The presence of oxygen is fundamental for ROS generation, ultimately causing the death of tumour cells. This project aims to develop hemoglobin drug delivery nanocarriers in the nano and submicron range for simultaneous oxygen and photosensitizer delivery to tumour tissue for a more efficient Photodynamic Therapy. Hemoglobin-based nanocarriers (HOBCs) will be prepared by co-precipitation of hemoglobin with carbonates and surface coating with bovine serum albumin. The carriers will transport oxygen complexed to hemoglobin while photosensitizer molecules will be entrapped in the core. Carriers will be modified with homing peptides to target them to cancer cells. In vitro studies will be conducted to study the uptake of HOBCs by cells, their intracellular fate, toxicity, and oxygen and photosensitizer delivery. In vivo fate of carriers will be studied in mice with radiolabeled carriers by Positron Emission Tomography and Single Emission Computer Tomography. The efficiency of the HOBCs for oxygen delivery and for PDT will be tested in vitro and in vivo in breast and skin cancer models. A multidisciplinary team has been gathered with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Imaging, Molecular Biology and Cancer Therapy from Germany, Estonia, Spain, Brazil, Argentina and Thailand. The participation of a SME will be fundamental for the future commercialization of project developments. OXIGENATED will actively work towards exchanging skills and knowledge through secondments of Early Stage and Experienced Researchers, and through networking and training activities. Seconded researchers will develop new scientific and complementary skills while exposed to new research environments.

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The information about "OXIGENATED" are provided by the European Opendata Portal: CORDIS opendata.

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