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OXIGENATED SIGNED

Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy

Total Cost €

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EC-Contrib. €

0

Partnership

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 OXIGENATED project word cloud

Explore the words cloud of the OXIGENATED project. It provides you a very rough idea of what is the project "OXIGENATED" about.

skin    limited    exchanging    molecular    science    networking    intracellular    spain    thailand    training    fate    therapy    positron    efficiency    scientists    team    argentina    molecule    sme    species    entrapped    estonia    scientific    transport    commercialization    nanocarriers    tomography    ultimately    computer    carriers    models    hypoxia    self    radiolabeled    skills    hemoglobin    nano    oxigenated    carbonates    photosensitizing    surface    exposed    treatment    radical    hobcs    drawback    tested    oxygen    material    mice    molecules    prepared    emission    cells    therapies    stage    modified    efficient    assembly    imaging    homing    photosensitizer    drug    forefront    tissue    chemistry    vivo    pdt    peptides    delivered    seconded    generate    cancer    bovine    secondments    core    coating    gathered    complementary    albumin    toxicity    death    actively    tumour    multidisciplinary    breast    causing    complexed    malignant    environments    fundamental    vitro    biology    germany    photodynamic    serum    content    physics    co    generation    submicron    single    participation    precipitation    simultaneous    ros    brazil   

Project "OXIGENATED" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 920˙000 €
 EC max contribution 920˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2018
 Funding Scheme MSCA-RISE
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 529˙000.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 211˙600.00
3    TARTU ULIKOOL EE (TARTU) participant 156˙400.00
4    Surflay Nanotec GmbH DE (BERLIN) participant 23˙000.00
5    CHULALONGKORN UNIVERSITY TH (BANGKOK) partner 0.00
6    FUNDACAO UNIVERSIDADE DE BRASILIA BR (BRASILIA DF) partner 0.00
7    UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN AR (SAN MARTIN BUENOS AIRES) partner 0.00
8    UNIVERSIDAD NACIONAL DEL SUR AR (BAHIA BLANCA) partner 0.00

Map

 Project objective

A major drawback of Photodynamic Therapy (PDT) and other therapies for cancer treatment is the limited oxygen content, hypoxia, in tumour tissue. In PDT a photosensitizing molecule is delivered to malignant tissue to generate radical oxygen species (ROS). The presence of oxygen is fundamental for ROS generation, ultimately causing the death of tumour cells. This project aims to develop hemoglobin drug delivery nanocarriers in the nano and submicron range for simultaneous oxygen and photosensitizer delivery to tumour tissue for a more efficient Photodynamic Therapy. Hemoglobin-based nanocarriers (HOBCs) will be prepared by co-precipitation of hemoglobin with carbonates and surface coating with bovine serum albumin. The carriers will transport oxygen complexed to hemoglobin while photosensitizer molecules will be entrapped in the core. Carriers will be modified with homing peptides to target them to cancer cells. In vitro studies will be conducted to study the uptake of HOBCs by cells, their intracellular fate, toxicity, and oxygen and photosensitizer delivery. In vivo fate of carriers will be studied in mice with radiolabeled carriers by Positron Emission Tomography and Single Emission Computer Tomography. The efficiency of the HOBCs for oxygen delivery and for PDT will be tested in vitro and in vivo in breast and skin cancer models. A multidisciplinary team has been gathered with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Imaging, Molecular Biology and Cancer Therapy from Germany, Estonia, Spain, Brazil, Argentina and Thailand. The participation of a SME will be fundamental for the future commercialization of project developments. OXIGENATED will actively work towards exchanging skills and knowledge through secondments of Early Stage and Experienced Researchers, and through networking and training activities. Seconded researchers will develop new scientific and complementary skills while exposed to new research environments.

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The information about "OXIGENATED" are provided by the European Opendata Portal: CORDIS opendata.

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