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GIDE SIGNED

Molecular diversification of inhibitory neurons during development

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GIDE project word cloud

Explore the words cloud of the GIDE project. It provides you a very rough idea of what is the project "GIDE" about.

am    developmental    functionally    questions    viral    forebrain    function    bipolar    transcriptomic    interneurons    successfully    environmental    play    confident    genetically    brain    progenitor    neural    cell    diverse    exploring    fascinating    rna    gain    interactive    reveal    retroviral    single    shaped    window    stability    complete    variety    genes    diversity    elucidate    schizophrenia    neurons    dependent    advantage    technologies    lineage    elucidating    body    combine    sequencing    suggests    intrinsic    candidate    disorder    zones    form    barcoding    subtypes    autism    connectivity    fate    mapping    data    training    predetermined    molecular    neuronal    genetic    extensive    inhibitory    full    mouse    neuropsychiatric    interneuron    underlying    class    immense    cognitive    vivo    programs    strategy    cortical    disease    circuits    neurobiology    ventral    integrate    adult    functions    cellular    manipulation    health    canonical    cooperate    disorders    throughput    mechanisms    critical    neurogenesis    ing    perinatal    utilize    takes    techniques    perturbation   

Project "GIDE" data sheet

The following table provides information about the project.

Coordinator		 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Total cost 1˙493˙382 €
 EC max contribution 1˙493˙382 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙493˙382.00

Map

 Project objective

Cortical interneurons are a diverse class of inhibitory neurons that play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions. A growing body of evidence suggests that perturbation of interneuron development can result in a variety of complex neuropsychiatric disorders, including autism, bipolar disorder, and schizophrenia. Thus, elucidating how interneurons develop and integrate into canonical brain circuits is crucial for understanding the brain in both health and disease.

During perinatal development, intrinsic and environmental processes cooperate to establish the adult form of brain connectivity and behaviour control. To elucidate the molecular mechanisms underlying these interactive processes, I propose to combine genetic fate-mapping techniques with high-throughput single-cell RNA sequencing technologies to gain a detailed understanding of neurogenesis at the cellular level and elucidate how an immense diversity of interneuron subtypes is generated (Aim 1). Furthermore, I will utilize a novel retroviral barcoding strategy to reveal how much of an interneuron’s fate is genetically predetermined by lineage within progenitor zones of the ventral forebrain (Aim 2). Finally, I will study the genetic mechanisms that enable cell intrinsic programs to be shaped by environmental activity-dependent processes during the critical window of development (Aim 3). Candidate genes resulting from these aims will be functionally characterized through gain of function and loss of function methods.

This proposal takes full advantage of my extensive training in viral and mouse genetic techniques, single-cell transcriptomic data processing, and in vivo manipulation of neuronal activity. I am confident that I will be able to successfully complete the proposed aims while exploring fascinating and long-standing questions of developmental neurobiology.

 Deliverables

List of deliverables.
Data Management Plan (DMP) Open Research Data Pilot 2020-02-12 17:33:55

Take a look to the deliverables list in detail:  detailed list of GIDE deliverables.

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The information about "GIDE" are provided by the European Opendata Portal: CORDIS opendata.

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