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GIDE SIGNED

Molecular diversification of inhibitory neurons during development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GIDE project word cloud

Explore the words cloud of the GIDE project. It provides you a very rough idea of what is the project "GIDE" about.

training    complete    interneuron    genetically    stability    candidate    neurogenesis    circuits    programs    underlying    brain    subtypes    diverse    cellular    viral    schizophrenia    transcriptomic    ventral    genes    cell    vivo    rna    body    diversity    interneurons    functionally    utilize    fate    questions    takes    intrinsic    cortical    autism    exploring    integrate    window    variety    interactive    extensive    disorder    forebrain    predetermined    perturbation    canonical    neural    techniques    cooperate    developmental    function    full    dependent    barcoding    bipolar    disorders    molecular    data    adult    neurobiology    strategy    successfully    inhibitory    class    neurons    mapping    retroviral    reveal    combine    functions    perinatal    manipulation    technologies    connectivity    confident    sequencing    health    neuropsychiatric    ing    form    zones    progenitor    single    am    throughput    shaped    advantage    play    fascinating    immense    mechanisms    cognitive    elucidating    lineage    neuronal    disease    environmental    mouse    suggests    genetic    gain    critical    elucidate   

Project "GIDE" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙493˙382 €
 EC max contribution 1˙493˙382 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙493˙382.00

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 Project objective

Cortical interneurons are a diverse class of inhibitory neurons that play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions. A growing body of evidence suggests that perturbation of interneuron development can result in a variety of complex neuropsychiatric disorders, including autism, bipolar disorder, and schizophrenia. Thus, elucidating how interneurons develop and integrate into canonical brain circuits is crucial for understanding the brain in both health and disease.

During perinatal development, intrinsic and environmental processes cooperate to establish the adult form of brain connectivity and behaviour control. To elucidate the molecular mechanisms underlying these interactive processes, I propose to combine genetic fate-mapping techniques with high-throughput single-cell RNA sequencing technologies to gain a detailed understanding of neurogenesis at the cellular level and elucidate how an immense diversity of interneuron subtypes is generated (Aim 1). Furthermore, I will utilize a novel retroviral barcoding strategy to reveal how much of an interneuron’s fate is genetically predetermined by lineage within progenitor zones of the ventral forebrain (Aim 2). Finally, I will study the genetic mechanisms that enable cell intrinsic programs to be shaped by environmental activity-dependent processes during the critical window of development (Aim 3). Candidate genes resulting from these aims will be functionally characterized through gain of function and loss of function methods.

This proposal takes full advantage of my extensive training in viral and mouse genetic techniques, single-cell transcriptomic data processing, and in vivo manipulation of neuronal activity. I am confident that I will be able to successfully complete the proposed aims while exploring fascinating and long-standing questions of developmental neurobiology.

 Deliverables

List of deliverables.
Data Management Plan (DMP) Open Research Data Pilot 2020-02-12 17:33:55

Take a look to the deliverables list in detail:  detailed list of GIDE deliverables.

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