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GIDE SIGNED

Molecular diversification of inhibitory neurons during development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GIDE project word cloud

Explore the words cloud of the GIDE project. It provides you a very rough idea of what is the project "GIDE" about.

neurobiology    developmental    am    integrate    immense    ing    genetically    takes    lineage    genetic    confident    rna    health    manipulation    sequencing    fate    perturbation    combine    mouse    single    vivo    disorder    interneuron    window    cell    form    molecular    forebrain    techniques    diverse    environmental    class    mapping    reveal    utilize    cognitive    progenitor    advantage    cooperate    disorders    schizophrenia    mechanisms    full    exploring    perinatal    programs    extensive    strategy    variety    questions    body    stability    connectivity    disease    inhibitory    autism    technologies    cortical    complete    predetermined    diversity    functions    barcoding    fascinating    interactive    retroviral    transcriptomic    circuits    function    successfully    subtypes    dependent    ventral    neuropsychiatric    elucidating    candidate    cellular    zones    neural    gain    neurogenesis    critical    training    neuronal    suggests    bipolar    canonical    elucidate    play    neurons    throughput    data    functionally    adult    interneurons    viral    intrinsic    shaped    underlying    genes    brain   

Project "GIDE" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙493˙382 €
 EC max contribution 1˙493˙382 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙493˙382.00

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 Project objective

Cortical interneurons are a diverse class of inhibitory neurons that play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions. A growing body of evidence suggests that perturbation of interneuron development can result in a variety of complex neuropsychiatric disorders, including autism, bipolar disorder, and schizophrenia. Thus, elucidating how interneurons develop and integrate into canonical brain circuits is crucial for understanding the brain in both health and disease.

During perinatal development, intrinsic and environmental processes cooperate to establish the adult form of brain connectivity and behaviour control. To elucidate the molecular mechanisms underlying these interactive processes, I propose to combine genetic fate-mapping techniques with high-throughput single-cell RNA sequencing technologies to gain a detailed understanding of neurogenesis at the cellular level and elucidate how an immense diversity of interneuron subtypes is generated (Aim 1). Furthermore, I will utilize a novel retroviral barcoding strategy to reveal how much of an interneuron’s fate is genetically predetermined by lineage within progenitor zones of the ventral forebrain (Aim 2). Finally, I will study the genetic mechanisms that enable cell intrinsic programs to be shaped by environmental activity-dependent processes during the critical window of development (Aim 3). Candidate genes resulting from these aims will be functionally characterized through gain of function and loss of function methods.

This proposal takes full advantage of my extensive training in viral and mouse genetic techniques, single-cell transcriptomic data processing, and in vivo manipulation of neuronal activity. I am confident that I will be able to successfully complete the proposed aims while exploring fascinating and long-standing questions of developmental neurobiology.

 Deliverables

List of deliverables.
Data Management Plan (DMP) Open Research Data Pilot 2020-02-12 17:33:55

Take a look to the deliverables list in detail:  detailed list of GIDE deliverables.

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