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GIDE SIGNED

Molecular diversification of inhibitory neurons during development

Total Cost €

0

EC-Contrib. €

0

Partnership

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 GIDE project word cloud

Explore the words cloud of the GIDE project. It provides you a very rough idea of what is the project "GIDE" about.

autism    intrinsic    candidate    class    mapping    canonical    circuits    stability    questions    neurons    environmental    takes    cell    rna    cortical    neuropsychiatric    strategy    ing    genes    confident    manipulation    progenitor    fate    training    critical    immense    techniques    neurobiology    advantage    developmental    successfully    suggests    combine    ventral    bipolar    extensive    adult    perturbation    fascinating    technologies    barcoding    inhibitory    health    utilize    cognitive    interneurons    function    programs    dependent    throughput    integrate    neural    viral    am    neurogenesis    exploring    data    forebrain    schizophrenia    full    body    cooperate    elucidating    zones    complete    cellular    transcriptomic    mouse    subtypes    predetermined    elucidate    diverse    disorder    genetic    neuronal    shaped    vivo    brain    form    retroviral    sequencing    disorders    diversity    play    molecular    lineage    perinatal    gain    underlying    interactive    mechanisms    connectivity    single    genetically    disease    interneuron    window    variety    functions    reveal    functionally   

Project "GIDE" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙493˙382 €
 EC max contribution 1˙493˙382 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙493˙382.00

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 Project objective

Cortical interneurons are a diverse class of inhibitory neurons that play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions. A growing body of evidence suggests that perturbation of interneuron development can result in a variety of complex neuropsychiatric disorders, including autism, bipolar disorder, and schizophrenia. Thus, elucidating how interneurons develop and integrate into canonical brain circuits is crucial for understanding the brain in both health and disease.

During perinatal development, intrinsic and environmental processes cooperate to establish the adult form of brain connectivity and behaviour control. To elucidate the molecular mechanisms underlying these interactive processes, I propose to combine genetic fate-mapping techniques with high-throughput single-cell RNA sequencing technologies to gain a detailed understanding of neurogenesis at the cellular level and elucidate how an immense diversity of interneuron subtypes is generated (Aim 1). Furthermore, I will utilize a novel retroviral barcoding strategy to reveal how much of an interneuron’s fate is genetically predetermined by lineage within progenitor zones of the ventral forebrain (Aim 2). Finally, I will study the genetic mechanisms that enable cell intrinsic programs to be shaped by environmental activity-dependent processes during the critical window of development (Aim 3). Candidate genes resulting from these aims will be functionally characterized through gain of function and loss of function methods.

This proposal takes full advantage of my extensive training in viral and mouse genetic techniques, single-cell transcriptomic data processing, and in vivo manipulation of neuronal activity. I am confident that I will be able to successfully complete the proposed aims while exploring fascinating and long-standing questions of developmental neurobiology.

 Deliverables

List of deliverables.
Data Management Plan (DMP) Open Research Data Pilot 2020-02-12 17:33:55

Take a look to the deliverables list in detail:  detailed list of GIDE deliverables.

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