Opendata, web and dolomites


Molecular diversification of inhibitory neurons during development

Total Cost €


EC-Contrib. €






 GIDE project word cloud

Explore the words cloud of the GIDE project. It provides you a very rough idea of what is the project "GIDE" about.

manipulation    health    diverse    strategy    interactive    subtypes    elucidating    vivo    single    successfully    disorder    am    ing    training    combine    rna    questions    dependent    immense    advantage    stability    adult    genes    neurogenesis    programs    cognitive    neurons    cell    gain    fate    takes    bipolar    perturbation    viral    play    inhibitory    ventral    integrate    cellular    mechanisms    schizophrenia    shaped    brain    technologies    reveal    interneuron    environmental    body    perinatal    disease    molecular    neuropsychiatric    confident    lineage    complete    cooperate    elucidate    variety    functions    transcriptomic    techniques    forebrain    form    function    cortical    autism    mapping    suggests    functionally    predetermined    fascinating    critical    full    connectivity    genetically    neural    class    genetic    extensive    circuits    canonical    neuronal    candidate    developmental    data    zones    mouse    window    neurobiology    sequencing    diversity    disorders    progenitor    throughput    exploring    utilize    retroviral    interneurons    intrinsic    barcoding    underlying   

Project "GIDE" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙493˙382 €
 EC max contribution 1˙493˙382 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cortical interneurons are a diverse class of inhibitory neurons that play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions. A growing body of evidence suggests that perturbation of interneuron development can result in a variety of complex neuropsychiatric disorders, including autism, bipolar disorder, and schizophrenia. Thus, elucidating how interneurons develop and integrate into canonical brain circuits is crucial for understanding the brain in both health and disease.

During perinatal development, intrinsic and environmental processes cooperate to establish the adult form of brain connectivity and behaviour control. To elucidate the molecular mechanisms underlying these interactive processes, I propose to combine genetic fate-mapping techniques with high-throughput single-cell RNA sequencing technologies to gain a detailed understanding of neurogenesis at the cellular level and elucidate how an immense diversity of interneuron subtypes is generated (Aim 1). Furthermore, I will utilize a novel retroviral barcoding strategy to reveal how much of an interneuron’s fate is genetically predetermined by lineage within progenitor zones of the ventral forebrain (Aim 2). Finally, I will study the genetic mechanisms that enable cell intrinsic programs to be shaped by environmental activity-dependent processes during the critical window of development (Aim 3). Candidate genes resulting from these aims will be functionally characterized through gain of function and loss of function methods.

This proposal takes full advantage of my extensive training in viral and mouse genetic techniques, single-cell transcriptomic data processing, and in vivo manipulation of neuronal activity. I am confident that I will be able to successfully complete the proposed aims while exploring fascinating and long-standing questions of developmental neurobiology.


List of deliverables.
Data Management Plan (DMP) Open Research Data Pilot 2020-02-12 17:33:55

Take a look to the deliverables list in detail:  detailed list of GIDE deliverables.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GIDE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GIDE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

InsideChromatin (2019)

Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains

Read More  

SuperH (2019)

Discovery and Characterization of Hydrogen-Based High-Temperature Superconductors

Read More  


The Enemy of the Good: Towards a Theory of Moral Progress

Read More