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StarT SIGNED

European Training Network to Diagnose, Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder

Total Cost €

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EC-Contrib. €

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Partnership

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Project "StarT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT GENT 

Organization address
address: SINT PIETERSNIEUWSTRAAT 25
city: GENT
postcode: 9000
website: http://www.ugent.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 3˙776˙714 €
 EC max contribution 3˙776˙714 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT GENT BE (GENT) coordinator 768˙960.00
2    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 531˙239.00
3    FONDAZIONE TELETHON IT (ROMA) participant 522˙999.00
4    NEWCELLS BIOTECH LIMITED UK (NEWCASTLE UPON TYNE) participant 303˙172.00
5    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 303˙172.00
6    UNIVERSITY OF LEEDS UK (LEEDS) participant 303˙172.00
7    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) participant 274˙684.00
8    PROQR THERAPEUTICS NV NL (LEIDEN) participant 265˙619.00
9    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 252˙788.00
10    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 250˙904.00
11    20MED THERAPEUTICS BV NL (ENSCHEDE) partner 0.00
12    EUROPEAN VISION INSTITUTE - EEIG BE (BRUXELLES) partner 0.00
13    F. HOFFMANN-LA ROCHE AG CH (BASEL) partner 0.00
14    Fighting Blindness IE (Dublin) partner 0.00
15    INTERNATIONAL RETINITIS PIGMENTOSA ASSOCIATION CH (ZURICH) partner 0.00

Map

 Project objective

StarT will create an interdisciplinary and intersectorial European training network focusing on different aspects of autosomal recessive Stargardt disease (STGD1), a frequent inherited blinding disorder that affects an estimated 925,000 persons worldwide. StarT research aims to uncover the regulation of its disease gene ABCA4 and its missing heritability, in order to develop novel treatments. StarT training will give young researchers unparalleled training opportunities in outstanding vision research groups with unique expertise in omics technologies, bio-informatics, stem cell biology, animal models of disease, and therapeutics, providing each ESR with the necessary competences in state-of-the-art academic and industrial research. STGD1 is due to ABCA4 mutations, however up to 35% of STGD1 cases carries one or no ABCA4 coding mutation. New unconventional classes of ABCA4 mutations were recently discovered by us, the significance of which largely remains elusive. In order to understand the mechanisms triggered by these missing ABCA4 mutations and to design new therapies for STGD1 cases, challenging research questions will be addressed by the integration of unique skills from this network. Early-Stage Researchers will perform cutting edge research using innovative and interdisciplinary approaches: (functional) genomics and transcriptomics, bio-informatics, CRISPR/Cas9 genome editing, generation of stem cell and animal disease models and design of new treatments. The training objectives will be met through academic and industrial training-by-research via individual research projects, secondments, and network-wide training sessions.

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The information about "START" are provided by the European Opendata Portal: CORDIS opendata.

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