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ENDpoiNTs SIGNED

Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ENDpoiNTs" data sheet

The following table provides information about the project.

Coordinator
UPPSALA UNIVERSITET 

Organization address
address: VON KRAEMERS ALLE 4
city: UPPSALA
postcode: 751 05
website: www.uu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 7˙578˙990 €
 EC max contribution 6˙889˙033 € (91%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UPPSALA UNIVERSITET SE (UPPSALA) coordinator 945˙322.00
2    INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH DE (DUESSELDORF) participant 1˙071˙300.00
3    STICHTING VU NL (AMSTERDAM) participant 926˙776.00
4    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 898˙517.00
5    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 632˙133.00
6    GREEN TOX GMBH CH (ZURICH) participant 411˙890.00
7    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 334˙856.00
8    INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FR (PARIS) participant 315˙525.00
9    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 315˙437.00
10    UNIVERSITAT KONSTANZ DE (KONSTANZ) participant 300˙000.00
11    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 199˙375.00
12    UMEA UNIVERSITET SE (UMEA) participant 198˙750.00
13    ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI US (NEW YORK) participant 124˙972.00
14    BRUNEL UNIVERSITY LONDON UK (UXBRIDGE) participant 112˙500.00
15    KARLSTADS UNIVERSITET SE (KARLSTAD) participant 101˙677.00
16    MURDOCH CHILDRENS RESEARCH INSTITUTE AU (PARKVILLE) participant 0.00
17    THE UNIVERSITY OF QUEENSLAND AU (BRISBANE) participant 0.00
18    UNIVERSITY OF MELBOURNE AU (MELBOURNE) participant 0.00

Map

 Project objective

Clear evidence supports associations between endocrine disrupting chemical (EDC) exposure and impaired neurodevelopment. Yet, current hazard assessment of EDCs does not address developmental neurotoxicity. This is due to lack of scientific knowledge on how endocrine disruption is linked to developmental neurotoxicity (DNT). Thus there is an urgent need for novel testing and screening tools to address ED-induced DNT, based on new scientific knowledge. This calls for rapid advances in basic research as well as in the development of screening and testing tools close to the end-users. ENDpoiNTs will address this need by i) integrating advanced expertise in the EDC and DNT fields, two so far rather independent toxicology communities, and ii) continuous interaction with European and international key stakeholders. By combining state-of-the-art in silico and in vitro tools, innovative experimental designs and technologies, and advanced biostatistics on human epidemiological and biomonitoring data, ENDpoiNTs will 1) Generate the necessary scientific insights on the correlative and causal links between endocrine disruption and DNT; 2) Develop predictive in silico tools for chemical screening using machine learning and combination of evidence; 3) Develop and validate in vitro tools for chemical screening and testing that address sex- and species differences; 4) Develop novel molecular endpoints for existing animal-based test guidelines by integrating in vitro, in vivo, and human omics data with behavioural outcomes; 5) Ensure human relevance by linking experimental and epidemiological evidence; 6) Develop an integrated testing approach based on the developed in silico, in vitro, and in vivo assays and molecular markers; 7) Ensure regulatory relevance by developing strategies for implementation of these tools and endpoints into regulatory frameworks. In this way, ENDpoiNTs will meet the scientific, regulatory, and societal needs for improved hazard and risk assessment of EDCs

 Deliverables

List of deliverables.
Launch of Website, logo and flyer Websites, patent fillings, videos etc. 2020-04-21 01:15:02
1st animation Websites, patent fillings, videos etc. 2020-04-21 01:15:02
Set of test compounds Documents, reports 2020-04-21 01:15:02

Take a look to the deliverables list in detail:  detailed list of ENDpoiNTs deliverables.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ENDPOINTS" project.

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Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "ENDPOINTS" are provided by the European Opendata Portal: CORDIS opendata.

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