#	Pagina
attuale pagina	/open-h2020/projects/219315/index.html

Opendata, web and dolomites

ARBODYNAMIC SIGNED

Coupling dynamic population immunity profiles and host behaviours to arboviral spread

Total Cost €

EC-Contrib. €

Partnership

Views

ARBODYNAMIC project word cloud

Explore the words cloud of the ARBODYNAMIC project. It provides you a very rough idea of what is the project "ARBODYNAMIC" about.

explore lineages diversity mosquito endemically thailand people year contribution hypotheses isolates found inferences sources mobility time interconnect reconstruct move outbreaks serotypes decades population prevalent profile viral infect vector strain arbovirus distributions unknown location mechanistic immune zika arboviruses combination profiles host transmissibility immunity disease behaviors chikungunya spread human archived abundance circulated pathogen dengue densities virus serotype appear millions excellent dictate full dynamics patterns endemic models data genome appropriate compare drive contact largely maintenance integrate exist interact evolve mechanisms emergence arboviral drivers disentangle fundamental period globally historic competing questions sequences geolocated

Project "ARBODYNAMIC" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙499˙896 €
EC max contribution	1˙499˙896 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-STG
Funding Scheme	ERC-STG
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	1˙463˙646.00
2	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	36˙250.00

Map

Project objective

Arboviruses infect millions of people each year, however, mechanisms that drive viral emergence and maintenance remain largely unknown. A combination of host factors (e.g., human mobility), mosquito factors (e.g., abundance) and viral factors (e.g., transmissibility) interconnect to drive spread. Further, for endemic arboviruses, complex patterns of population immunity, built up over many years, appear key to the emergence of particular lineages. To disentangle the contribution of these different drivers, we need detailed data from the same pathogen system over a long time period from the same location. In addition, we need new methods, which can integrate these different data sources and allow appropriate mechanistic inferences. In this project, I will use the most globally prevalent arbovirus, dengue virus, as a case study. I will focus on Thailand where all four dengue serotypes have circulated endemically for decades and excellent long-term data and isolates exist, to address two fundamental questions: i) How do population-level patterns of immunity evolve over time and what is their impact on strain dynamics? I will use mechanistic models applied to historic serotype-specific case data to reconstruct the evolving immune profile of the population and explore the impact of immunity on viral diversity using sequences from archived isolates from each year over a 50-year period. ii) How do human behaviors, vector densities interact with immunity to dictate spread? I will work with geolocated full genome sequences from across Thailand and use detailed data on how people move, their contact patterns, their immunity profiles and mosquito distributions to study competing hypotheses of how arboviruses spread. I will compare the key drivers of dengue spread with that found for outbreaks of Zika and chikungunya. This proposal addresses fundamental questions about the mechanisms that drive arboviral emergence and spread that will be relevant across disease systems.

Publications

List of publications.
year	authors and title	journal	last update
2019	Kriangsak Ruchusatsawat, Pattara Wongjaroen, Arisara Posanacharoen, Isabel Rodriguez-Barraquer, Somchai Sangkitporn, Derek A T Cummings, Henrik Salje Long-term circulation of Zika virus in Thailand: an observational study published pages: 439-446, ISSN: 1473-3099, DOI: 10.1016/s1473-3099(18)30718-7	The Lancet Infectious Diseases 19/4	2020-01-16

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ARBODYNAMIC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ARBODYNAMIC" are provided by the European Opendata Portal: CORDIS opendata.