Explore the words cloud of the iPSpine project. It provides you a very rough idea of what is the project "iPSpine" about.
The following table provides information about the project.
|Coordinator Country||Netherlands [NL]|
|Total cost||15˙396˙031 €|
|EC max contribution||14˙959˙781 € (97%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2019-01-01 to 2023-12-31|
Take a look of project's partnership.
|1||UNIVERSITEIT UTRECHT||NL (UTRECHT)||coordinator||3˙522˙312.00|
|2||TECHNISCHE UNIVERSITEIT EINDHOVEN||NL (EINDHOVEN)||participant||1˙306˙771.00|
|3||UNIVERSITE DE NANTES||FR (NANTES CEDEX 1)||participant||1˙250˙312.00|
|4||SHEFFIELD HALLAM UNIVERSITY||UK (SHEFFIELD)||participant||1˙126˙572.00|
|5||NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN||DE (REUTLINGEN)||participant||867˙156.00|
|6||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||participant||826˙617.00|
|7||NTRANS TECHNOLOGIES BV||NL (UTRECHT)||participant||770˙625.00|
|8||UNIVERSITAIR MEDISCH CENTRUM UTRECHT||NL (UTRECHT)||participant||708˙710.00|
|9||PHARMALEX GMBH||DE (FRIEDRICHSDORF)||participant||676˙381.00|
|10||NATIONAL UNIVERSITY OF IRELAND GALWAY||IE (Galway)||participant||671˙935.00|
|11||UNIVERSITA CAMPUS BIO MEDICO DI ROMA||IT (ROMA)||participant||557˙975.00|
|12||UNIVERSITAET ULM||DE (ULM)||participant||501˙583.00|
|13||AO-FORSCHUNGSINSTITUT DAVOS||CH (DAVOS PLATZ)||participant||491˙250.00|
|14||UNIVERSITAET BERN||CH (BERN)||participant||419˙000.00|
|15||UNIVERSITE DE MONTPELLIER||FR (MONTPELLIER)||participant||364˙903.00|
|16||SPINESERV GMBH & CO.KG||DE (ULM)||participant||321˙250.00|
|17||Catalyze B.V.||NL (AMSTERDAM-DUIVENDRECHT)||participant||251˙250.00|
|18||UNIVERSITY OF MIAMI||US (CORAL GABLES MIAMI)||participant||250˙175.00|
|19||STICHTING NATIONAAL REUMAFONDS||NL (AMSTERDAM)||participant||75˙000.00|
|20||THE UNIVERSITY OF HONG KONG||HK (Pokfulam)||participant||0.00|
Low back pain (LBP) is a leading cause of disability and morbidity worldwide. It is widely accepted that a major contributor to LBP is intervertebral disc degeneration (IDD). IDD account for at least 40% (~280 million) of all LBP cases, leading to an EU-economic burden of ~€240 billion. These patients receive conservative treatment (e.g. pain relief medication and physiotherapy). When the latter is unsatisfactory, the only option left are invasive and costly surgical intervention. To date, no treatments halt or reverse IDD. Despite the profound socioeconomic burden and impact of IDD, decreasing the quality of life of millions of people, a game-changing treatment strategy for IDD-induced LBP is almost non-existent. The iPSpine consortium was formed to initiate a European-led research effort to identify a future advanced therapeutic strategy that results into a radical new treatment of IDD-induced LBP. With their multi-disciplinary expertise in the development of advanced therapies and their translation from bench to bedside, the aim of the iPSpine team is to investigate and develop a new advanced therapy medicinal product (ATMP) of the future, based on a novel developmental biology-based therapeutic strategy employing pluripotent stem cells (iPSC) and smart biomaterials. The iPSpine consortium will develop and demonstrate Proof-of-concept with the aid of novel and extended knowledge, tools and technology platforms. Hereby, iPSpine has the ambition to make a significant contribution by reducing translational bottlenecks through open innovation and take European leadership in the development of ATMPs. The iPSpine impact: iPSpine seeks to offer novel technologies and ATMPs for the advanced therapy research and development community. IDD will be the showcase, offering improved quality of life for millions of patients with IDD-induced LBP, through long-lasting reduction of LBP, reduced LBP-related premature retirement, and improved socio-economic contribution.
|Data Management Plan||Open Research Data Pilot||2019-10-08 17:18:36|
|Set up of Patient Advisory Board||Documents, reports||2019-05-28 20:18:09|
|Guidelines and requirements for pre-in vivo evaluation of IVD advanced therapeutics||Documents, reports||2019-05-28 20:18:09|
|Project website||Websites, patent fillings, videos etc.||2019-05-28 20:18:09|
Take a look to the deliverables list in detail: detailed list of iPSpine deliverables.
|year||authors and title||journal||last update|
Frances C. Bach, Kim M. Rooij, Frank M. Riemers, Joseph W. Snuggs, Willem A. M. Jong, Ying Zhang, Laura B. Creemers, Danny Chan, Christine Le Maitre, Marianna A. Tryfonidou
Hedgehog proteins and parathyroid hormoneâ€related protein are involved in intervertebral disc maturation, degeneration, and calcification
published pages: , ISSN: 2572-1143, DOI: 10.1002/jsp2.1071
|JOR SPINE 2/4||2020-01-29|
Daniela A. Frauchiger, Adel Tekari, Rahel D. May, Emina DÅ¾afo, Samantha C.W. Chan, Jivko Stoyanov, Alessandro Bertolo, Xingshuo Zhang, Julien Guerrero, Daisuke Sakai, Jordy Schol, Sibylle Grad, Marianna Tryfonidou, Lorin M. Benneker, Benjamin Gantenbein
Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods
published pages: 571-580, ISSN: 1937-3384, DOI: 10.1089/ten.tec.2018.0375
|Tissue Engineering Part C: Methods 25/10||2020-01-29|
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The information about "IPSPINE" are provided by the European Opendata Portal: CORDIS opendata.
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