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EVPRO SIGNED

EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

Total Cost €

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EC-Contrib. €

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Partnership

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EVPRO project word cloud

Explore the words cloud of the EVPRO project. It provides you a very rough idea of what is the project "EVPRO" about.

matrix integration patients reaction severe purify physical surface gmp store regeneration host evpro site revision versus effect osteogenic establishing pro cell stem enhanced technologies drugs successful individual osteoarticular smart rejection multidisciplinary conformed introduce tissue protection confinement exert direct overcomes anti implant refractory implantation human safe setting graft local regulated mesenchymal titan micropores difficult proximity absorbed function evs bed humans progression extracellular inflammation medically hydrogel coating trials endoprosthesis resolution symptoms conventional self clinical status microfluidic tio2 surgical biodegradable proof mostly vesicles uniform regenerative msc affix osseointegration successfully prosthesis release inflammatory shaft disease suppress reactions treat select steroid post

Project "EVPRO" data sheet

The following table provides information about the project.

Coordinator	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	5˙799˙088 €
EC max contribution	5˙799˙088 € (100%)
Programme	1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-TR-IND-2018
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Organization address address: HANSASTRASSE 27C city: MUNCHEN postcode: 80686 website: www.fraunhofer.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	coordinator	865˙646.00
2	UNIVERSITAETSKLINIKUM ESSEN UNIVERSITAETSKLINIKUM ESSEN Organization address address: HUFELANDSTRASSE 55 city: ESSEN postcode: 45147 website: www.uk-essen.de/frauenklinik/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ESSEN)	participant	603˙250.00
3	DUBLIN CITY UNIVERSITY DUBLIN CITY UNIVERSITY Organization address address: Glasnevin city: DUBLIN postcode: 9 website: www.dcu.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	569˙070.00
4	DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV Organization address address: FORCKENBECKSTRASSE 50 city: AACHEN postcode: 52074 website: www.dwi.rwth-aachen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	526˙080.00
5	MEOTEC GMBH & CO KG MEOTEC GMBH & CO KG Organization address address: PHILIPSSTRASSE 8 city: AACHEN postcode: 52068 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	511˙250.00
6	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	509˙363.00
7	POLITECNICO DI TORINO POLITECNICO DI TORINO Organization address address: CORSO DUCA DEGLI ABRUZZI 24 city: TORINO postcode: 10129 website: www.polito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	500˙000.00
8	UNIVERSITAETSKLINIKUM KNAPPSCHAFTSKRANKENHAUS BOCHUM GMBH UNIVERSITAETSKLINIKUM KNAPPSCHAFTSKRANKENHAUS BOCHUM GMBH Organization address address: IN DER SCHORNAU 23 25 city: BOCHUM postcode: 44892 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BOCHUM)	participant	470˙376.00
9	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Organization address address: College Green city: DUBLIN postcode: 2 website: www.tcd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	438˙327.00
10	LONZA NETHERLANDS BV LONZA NETHERLANDS BV Organization address address: OXFORDLAAN 70 city: MAASTRICHT postcode: 6229 EV website: www.pharmacell.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	411˙975.00
11	STRYKER EUROPEAN OPERATIONS BV STRYKER EUROPEAN OPERATIONS BV Organization address address: HERIKERBERGWEG 110 city: AMSTERDAM postcode: 1101 CM website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	393˙750.00

Map

Project objective

Revision endoprosthesis are mostly associated with post-surgical physical symptoms that can lead to long-term confinement to bed and in severe cases to implant rejection. Severe inflammatory reactions in the endoprosthesis shaft can occur due to a previous long-term prosthesis. Medically managing the inflammation process is challenging as it is difficult to introduce drugs to the site of inflammation after implantation of the revision endoprosthesis. EVPRO overcomes this problem by using human mesenchymal stem cell derived extracellular vesicles (MSC-EVs) which are known to suppress inflammatory reaction in humans, exert pro-regenerative effects in osteogenic setting and successfully treat patients with steroid-refractory graft-versus-host disease. In this project the MSC-EVs will be applied in direct physical proximity to the site of inflammation and will therefore affix on the implant surface to deliver their anti-inflammatory and regenerative effect in response to the local inflammation status. This will be achieved by safe integration of the MSC-EVs in a smart biodegradable hydrogel that is absorbed into the micropores of a TiO2 coating on the surface of conventional titan endoprosthesis. EVPRO enables the progression of each individual technology, along with EVPRO system level integration developments, into pre-clinical trials, this means in detail, the development of a GMP conformed large scale production of MSC-EVs, the establishing of an uniform method to purify and select the most potential MSC-EVs with a microfluidic system and the design of a self-regulated hydrogel as protection matrix of MSC-EVs with the function to store and release MSC-EVs in response to the inflammation status, The EVPRO project is an integration of multidisciplinary post-proof of concept technologies which enables the successful resolution of the enhanced osseointegration of endoprosthesis for osteoarticular tissue regeneration.

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