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EVPRO SIGNED

EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

Total Cost €

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EC-Contrib. €

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Partnership

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 EVPRO project word cloud

Explore the words cloud of the EVPRO project. It provides you a very rough idea of what is the project "EVPRO" about.

osteogenic    medically    steroid    evpro    tio2    coating    progression    refractory    technologies    suppress    revision    surgical    confinement    establishing    stem    resolution    drugs    integration    safe    patients    multidisciplinary    clinical    affix    mesenchymal    physical    vesicles    proximity    humans    protection    trials    host    inflammation    extracellular    store    bed    biodegradable    self    individual    successfully    conformed    local    gmp    symptoms    human    regulated    introduce    microfluidic    site    purify    severe    anti    matrix    disease    setting    proof    function    select    msc    uniform    mostly    inflammatory    rejection    status    absorbed    micropores    overcomes    surface    difficult    hydrogel    tissue    osteoarticular    shaft    cell    pro    treat    osseointegration    implant    smart    effect    implantation    evs    reaction    reactions    release    enhanced    exert    regeneration    prosthesis    endoprosthesis    versus    conventional    post    titan    direct    successful    graft    regenerative   

Project "EVPRO" data sheet

The following table provides information about the project.

Coordinator
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. 

Organization address
address: HANSASTRASSE 27C
city: MUNCHEN
postcode: 80686
website: www.fraunhofer.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 5˙799˙088 €
 EC max contribution 5˙799˙088 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) coordinator 865˙646.00
2    UNIVERSITAETSKLINIKUM ESSEN DE (ESSEN) participant 603˙250.00
3    DUBLIN CITY UNIVERSITY IE (DUBLIN) participant 569˙070.00
4    DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV DE (AACHEN) participant 526˙080.00
5    MEOTEC GMBH & CO KG DE (AACHEN) participant 511˙250.00
6    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 509˙363.00
7    POLITECNICO DI TORINO IT (TORINO) participant 500˙000.00
8    UNIVERSITAETSKLINIKUM KNAPPSCHAFTSKRANKENHAUS BOCHUM GMBH DE (BOCHUM) participant 470˙376.00
9    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) participant 438˙327.00
10    LONZA NETHERLANDS BV NL (MAASTRICHT) participant 411˙975.00
11    STRYKER EUROPEAN OPERATIONS BV NL (AMSTERDAM) participant 393˙750.00

Map

 Project objective

Revision endoprosthesis are mostly associated with post-surgical physical symptoms that can lead to long-term confinement to bed and in severe cases to implant rejection. Severe inflammatory reactions in the endoprosthesis shaft can occur due to a previous long-term prosthesis. Medically managing the inflammation process is challenging as it is difficult to introduce drugs to the site of inflammation after implantation of the revision endoprosthesis. EVPRO overcomes this problem by using human mesenchymal stem cell derived extracellular vesicles (MSC-EVs) which are known to suppress inflammatory reaction in humans, exert pro-regenerative effects in osteogenic setting and successfully treat patients with steroid-refractory graft-versus-host disease. In this project the MSC-EVs will be applied in direct physical proximity to the site of inflammation and will therefore affix on the implant surface to deliver their anti-inflammatory and regenerative effect in response to the local inflammation status. This will be achieved by safe integration of the MSC-EVs in a smart biodegradable hydrogel that is absorbed into the micropores of a TiO2 coating on the surface of conventional titan endoprosthesis. EVPRO enables the progression of each individual technology, along with EVPRO system level integration developments, into pre-clinical trials, this means in detail, the development of a GMP conformed large scale production of MSC-EVs, the establishing of an uniform method to purify and select the most potential MSC-EVs with a microfluidic system and the design of a self-regulated hydrogel as protection matrix of MSC-EVs with the function to store and release MSC-EVs in response to the inflammation status, The EVPRO project is an integration of multidisciplinary post-proof of concept technologies which enables the successful resolution of the enhanced osseointegration of endoprosthesis for osteoarticular tissue regeneration.

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The information about "EVPRO" are provided by the European Opendata Portal: CORDIS opendata.

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