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ZebraZoom SIGNED

ZebraZoom: Kinematic analysis for drug and genetic screening in zebrafish

Total Cost €

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EC-Contrib. €

0

Partnership

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 ZebraZoom project word cloud

Explore the words cloud of the ZebraZoom project. It provides you a very rough idea of what is the project "ZebraZoom" about.

consequently    decade    behavioural    discovery    human    genetic    labs    disease    humans    reliably    dr    platform    juveniles    kinematics    degree    erc    resolve    pain    neurological    business    limited    citizens    strength    zebrafish    relevance    animals    accuracy    critical    resolved    models    posture    pharmaceutical    market    diseases    elaborate    speed    starting    administration    organism    movement    grant    fine    model    wyart    treatment    crude    sensory    quantify    homology    shares    resolution    companies    molecules    drug    devise    neurodegenerative    larvae    zebrazoom    behavior    genes    throughput    population    movements    plan    optoloco    motor    categorise    performed    manipulations    relies    fast    suffering    mutant    solutions    chronic    efficient    ways    animal    investigation    types    70    genome    interpretation    poc    millions    concluding    marketing    quantitative    suited    commercial    emerged    disorders    screening    with    indicative    data    kinematic    urgent    screen    last    defects    drugs    functions    ideal   

Project "ZebraZoom" data sheet

The following table provides information about the project.

Coordinator
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE 

Organization address
address: BOULEVARD DE L'HOPITAL 47
city: PARIS
postcode: 75013
website: http://icm-institute.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FR (PARIS) coordinator 150˙000.00

Map

 Project objective

With millions of European citizens suffering from chronic pain and neurodegenerative disease, there is an urgent need for efficient solutions for drug screening in animal models. Discovery of new drugs and functions of genes involved in these human diseases relies on efficient ways to screen effects on animal behavior and at low cost. Zebrafish emerged in the last decade as an essential model for drug discovery as it is: i) a low cost genetic model organism whose genome shares 70% homology with human’s. ii) well-suited to fast and high throughput investigation of genes and molecules. iii) an ideal platform to study genes and pathways of relevance to disease in humans. Consequently, several companies are exploiting zebrafish research to devise new drugs for motor and neurological disorders. However, the current state of the art in commercial analysis of zebrafish behavior is limited to the analysis of crude parameters. In these conditions, the fast kinematics indicative of specific types of sensory and motor defects cannot be resolved. A fine kinematic analysis efficiently performed over large population of animals is crucial to reliably quantify defects in strength, posture or speed in mutant animals with and without with drug treatment. This accuracy is critical for concluding on the effects of drugs involved in motor functions, posture or pain. During her ERC starting grant OptoLoco, Dr. Wyart has developed ZebraZoom to resolve kinematic data with the necessary degree of resolution required for interpretation of motor defects. This approach enables the quantitative measurement of defects in speed, posture, and movement strength. In the ZebraZoom PoC, we will evaluate the market potential for a high-throughput method to quantify and categorise behavioural movements of zebrafish larvae/juveniles in response to drug administration and genetic manipulations and elaborate a marketing plan and business plan targeting for pharmaceutical companies and research labs.

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The information about "ZEBRAZOOM" are provided by the European Opendata Portal: CORDIS opendata.

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