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ZebraZoom SIGNED

ZebraZoom: Kinematic analysis for drug and genetic screening in zebrafish

Total Cost €

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EC-Contrib. €

0

Partnership

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 ZebraZoom project word cloud

Explore the words cloud of the ZebraZoom project. It provides you a very rough idea of what is the project "ZebraZoom" about.

juveniles    resolved    homology    shares    ideal    quantitative    platform    types    genes    efficient    indicative    relevance    larvae    data    neurological    drugs    model    models    poc    investigation    genetic    categorise    performed    disorders    zebrafish    companies    with    devise    kinematic    grant    resolve    plan    behavior    manipulations    administration    last    business    population    strength    zebrazoom    defects    concluding    degree    critical    kinematics    mutant    movement    animals    citizens    molecules    urgent    neurodegenerative    human    organism    starting    treatment    resolution    marketing    reliably    chronic    consequently    wyart    functions    fine    discovery    diseases    genome    screen    solutions    pain    70    dr    optoloco    interpretation    posture    movements    fast    quantify    sensory    decade    erc    elaborate    accuracy    relies    throughput    screening    animal    suited    millions    crude    drug    commercial    ways    emerged    suffering    humans    limited    labs    speed    disease    pharmaceutical    behavioural    motor    market   

Project "ZebraZoom" data sheet

The following table provides information about the project.

Coordinator
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE 

Organization address
address: BOULEVARD DE L'HOPITAL 47
city: PARIS
postcode: 75013
website: http://icm-institute.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE FR (PARIS) coordinator 150˙000.00

Map

 Project objective

With millions of European citizens suffering from chronic pain and neurodegenerative disease, there is an urgent need for efficient solutions for drug screening in animal models. Discovery of new drugs and functions of genes involved in these human diseases relies on efficient ways to screen effects on animal behavior and at low cost. Zebrafish emerged in the last decade as an essential model for drug discovery as it is: i) a low cost genetic model organism whose genome shares 70% homology with human’s. ii) well-suited to fast and high throughput investigation of genes and molecules. iii) an ideal platform to study genes and pathways of relevance to disease in humans. Consequently, several companies are exploiting zebrafish research to devise new drugs for motor and neurological disorders. However, the current state of the art in commercial analysis of zebrafish behavior is limited to the analysis of crude parameters. In these conditions, the fast kinematics indicative of specific types of sensory and motor defects cannot be resolved. A fine kinematic analysis efficiently performed over large population of animals is crucial to reliably quantify defects in strength, posture or speed in mutant animals with and without with drug treatment. This accuracy is critical for concluding on the effects of drugs involved in motor functions, posture or pain. During her ERC starting grant OptoLoco, Dr. Wyart has developed ZebraZoom to resolve kinematic data with the necessary degree of resolution required for interpretation of motor defects. This approach enables the quantitative measurement of defects in speed, posture, and movement strength. In the ZebraZoom PoC, we will evaluate the market potential for a high-throughput method to quantify and categorise behavioural movements of zebrafish larvae/juveniles in response to drug administration and genetic manipulations and elaborate a marketing plan and business plan targeting for pharmaceutical companies and research labs.

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The information about "ZEBRAZOOM" are provided by the European Opendata Portal: CORDIS opendata.

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