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NanoBRIGHT SIGNED

BRInGing nano-pHoTonics into the brain

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NanoBRIGHT" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 3˙496˙197 €
 EC max contribution 3˙496˙197 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 1˙638˙167.00
2    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III ES (MADRID) participant 713˙125.00
3    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 683˙125.00
4    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 461˙780.00

Map

 Project objective

NanoBRIGHT will develop a new approach to optically interface with the brain, referred to as “photonic-physiology”: a new technique with high-translational appeal that exploits light-metals interactions to interface with the brain, targeting specific diseases including brain tumors, epilepsy and traumatic brain injuries. This will allow to reach the long-term vision of developing novel cutting-edge optical approaches to study and treat pathological conditions of the brain without using genetically-encoded proteins, which represent the main limitation for optogenetic techniques currently employed to interface with the neural tissue.

The approach will be based on a unique science-enabled technology exploiting the spatial selectivity properties of multimodal tapered optical fibers to activate a subset of high-density plasmonic hotspots along the taper. The resulting implantable devices will establish a new approach to interface with brain, striving at:

1- Demonstrate the capability of photonics for detecting and treating pathological conditions of the brain without the use of genetically-encoded proteins. We plan to exploit SERS to differentiate between primary and secondary brain tumors and to outline new methods to study oxidative stress in epileptogenic tissue.

2- Upscaling the range of physiological phenomena that can be controlled by light in vivo beyond those achieved so far by genetically encoded proteins, including vasodilation to locally increase permeability of the blood-brain-barrier thus enhancing pharmacological delivery in well-targeted regions of brain tumors.

3-Proving that unconventional combination between light-matter interactions and photonic-physiology can be used to analyze comorbidities between different diseases, testing the influence of brain tumors on epilepsy or tumor influence on the electrical activity of nearby and distal neural cells.

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The information about "NANOBRIGHT" are provided by the European Opendata Portal: CORDIS opendata.

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