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Brain Health Toolbox SIGNED

The Brain Health Toolbox: Facilitating personalized decision-making for effective dementia prevention

Total Cost €

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EC-Contrib. €

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Partnership

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 Brain Health Toolbox project word cloud

Explore the words cloud of the Brain Health Toolbox project. It provides you a very rough idea of what is the project "Brain Health Toolbox" about.

prodromal    toolbox    combined    health    actual    multifactorial    disease    scenarios    markers    cultural    pharmacological    trials    brain    pattern    populations    outcome    contributors    highlight    platform    datasets    create    biomarker    ad    pioneering    settings    identification    dementia    economic    stages    heterogeneity    reference    monitoring    interventions    pathologies    seamless    quantifying    geographic    entire    preventing    aligning    interventional    assessing    prediction    missing    gap    dimensional    libraries    individual    designed    preventive    global    multimodal    risk    patients    stress    accurate    tools    adaptive    lifestyle    single    machine    models    learning    decision    profiling    individuals    failures    critical    continuum    preclinical    designing    personalized    intervention    prevention    selecting    alzheimer    longitudinal    covers    adapt    observational    trial    innovative    types    broad    bridging   

Project "Brain Health Toolbox" data sheet

The following table provides information about the project.

Coordinator
ITA-SUOMEN YLIOPISTO 

Organization address
address: YLIOPISTONRANTA 1 E
city: KUOPIO
postcode: 70211
website: www.uef.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙498˙268 €
 EC max contribution 1˙498˙268 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ITA-SUOMEN YLIOPISTO FI (KUOPIO) coordinator 1˙498˙268.00

Map

 Project objective

Preventing dementia and Alzheimer disease (AD) is a global priority. Previous single-intervention failures stress the critical need for a new multimodal preventive approach in these complex multifactorial conditions. The Brain Health Toolbox is designed to create a seamless continuum from accurate dementia prediction to effective prevention by i) developing the missing disease models and prediction tools for multimodal prevention; ii) testing them in actual multimodal prevention trials; and iii) bridging the gap between non-pharmacological and pharmacological approaches by designing a combined multimodal prevention trial based on a new European adaptive trial platform. Disease models and prediction tools will be multi-dimensional, i.e. a broad range of risk factors and biomarker types, including novel markers. An innovative machine learning method will be used for pattern identification and risk profiling to highlight most important contributors to an individual’s overall risk level. This is crucial for early identification of individuals with high dementia risk and/or high likelihood of specific brain pathologies, quantifying an individual’s prevention potential, and longitudinal risk and disease monitoring, also beyond trial duration. Three Toolbox test scenarios are considered: use for selecting target populations, assessing heterogeneity of intervention effects, and use as trial outcome. The project is based on a unique set-up aligning several new multimodal lifestyle trials aiming to adapt and test non-pharmacological interventions to different geographic, economic and cultural settings, with two reference libraries (observational - large datasets; and interventional - four recently completed pioneering multimodal lifestyle prevention trials). The Brain Health Toolbox covers the entire continuum from general populations to patients with preclinical/prodromal disease stages, and will provide tools for personalized decision-making for dementia prevention.

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The information about "BRAIN HEALTH TOOLBOX" are provided by the European Opendata Portal: CORDIS opendata.

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