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Brain Health Toolbox SIGNED

The Brain Health Toolbox: Facilitating personalized decision-making for effective dementia prevention

Total Cost €

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EC-Contrib. €

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Partnership

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 Brain Health Toolbox project word cloud

Explore the words cloud of the Brain Health Toolbox project. It provides you a very rough idea of what is the project "Brain Health Toolbox" about.

markers    intervention    geographic    profiling    combined    accurate    actual    preclinical    failures    lifestyle    pioneering    designing    highlight    dementia    preventive    types    prodromal    multimodal    assessing    designed    interventions    machine    settings    stress    pathologies    populations    health    patients    tools    brain    scenarios    monitoring    heterogeneity    models    platform    bridging    biomarker    prevention    critical    economic    libraries    individual    entire    pharmacological    contributors    continuum    covers    outcome    identification    cultural    pattern    adapt    gap    alzheimer    trial    global    personalized    risk    selecting    toolbox    single    ad    quantifying    trials    create    disease    stages    interventional    multifactorial    observational    reference    prediction    innovative    broad    individuals    dimensional    longitudinal    datasets    learning    missing    decision    aligning    seamless    adaptive    preventing   

Project "Brain Health Toolbox" data sheet

The following table provides information about the project.

Coordinator
ITA-SUOMEN YLIOPISTO 

Organization address
address: YLIOPISTONRANTA 1 E
city: KUOPIO
postcode: 70211
website: www.uef.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙498˙268 €
 EC max contribution 1˙498˙268 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ITA-SUOMEN YLIOPISTO FI (KUOPIO) coordinator 1˙498˙268.00

Map

 Project objective

Preventing dementia and Alzheimer disease (AD) is a global priority. Previous single-intervention failures stress the critical need for a new multimodal preventive approach in these complex multifactorial conditions. The Brain Health Toolbox is designed to create a seamless continuum from accurate dementia prediction to effective prevention by i) developing the missing disease models and prediction tools for multimodal prevention; ii) testing them in actual multimodal prevention trials; and iii) bridging the gap between non-pharmacological and pharmacological approaches by designing a combined multimodal prevention trial based on a new European adaptive trial platform. Disease models and prediction tools will be multi-dimensional, i.e. a broad range of risk factors and biomarker types, including novel markers. An innovative machine learning method will be used for pattern identification and risk profiling to highlight most important contributors to an individual’s overall risk level. This is crucial for early identification of individuals with high dementia risk and/or high likelihood of specific brain pathologies, quantifying an individual’s prevention potential, and longitudinal risk and disease monitoring, also beyond trial duration. Three Toolbox test scenarios are considered: use for selecting target populations, assessing heterogeneity of intervention effects, and use as trial outcome. The project is based on a unique set-up aligning several new multimodal lifestyle trials aiming to adapt and test non-pharmacological interventions to different geographic, economic and cultural settings, with two reference libraries (observational - large datasets; and interventional - four recently completed pioneering multimodal lifestyle prevention trials). The Brain Health Toolbox covers the entire continuum from general populations to patients with preclinical/prodromal disease stages, and will provide tools for personalized decision-making for dementia prevention.

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The information about "BRAIN HEALTH TOOLBOX" are provided by the European Opendata Portal: CORDIS opendata.

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