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BRAINMINT SIGNED

Brains and minds in transition: The dark side of neuroplasticity during sensitive life phases

Total Cost €

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EC-Contrib. €

0

Partnership

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 BRAINMINT project word cloud

Explore the words cloud of the BRAINMINT project. It provides you a very rough idea of what is the project "BRAINMINT" about.

pioneering    electrophysiology    hypothesis    neglecting    coherent    longitudinal    adolescence    traits    combination    mental    immune    emergence    investigation    architecture    missing    day    static    cutting    entity    utilize    transitions    exposed    environmental    life    leverage    effort    breakthroughs    fact    explanation    mechanistic    zeroing    massive    data    dynamic    human    genetics    plasticity    markers    brainmint    tools    expression    edge    environment    boost    phases    cognitive    host    vulnerability    inputs    gene    gt    gain    operandi    complexity    disorders    generalizability    mechanisms    brain    interactions    heritability    imaging    despite    revolution    individual    windows    mundi    link    largely    predictions       axis    dark    healthy    add    determined    treat    clinical    harm    risk    determinants    psychopathology    boundaries    modern    triggers    neuroplasticity    genetic    resolving    impasse    power    modus    enigmas    temporarily    vary    mind    pregnancy    dramatically   

Project "BRAINMINT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙446˙113 €
 EC max contribution 1˙446˙113 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 1˙446˙113.00

Map

 Project objective

The potential and boundaries of the human mind is determined by dynamic interactions between the environment and the individual genetic architecture. However, despite several breakthroughs, the genetic revolution has not provided a coherent account of the development of the mind and its disorders, and the missing heritability is large across human traits. One explanation of this impasse is the complexity of the gene-environment interactions. Current knowledge about the determinants of a healthy mind is largely based on studies whose modus operandi is to treat the environment as a static entity, neglecting to consider the crucial fact that environmental inputs and their genetic interactions vary dramatically between life phases.

The objective of BRAINMINT is to provide this missing link by zeroing in on two major life transitions, namely adolescence and pregnancy. These phases are characterized by temporarily increased brain plasticity, offering windows for adaptation and growth, but also host the emergence of common mental disorders. I propose that a multi-level investigation with this dark side of brain plasticity as the axis mundi will add a mechanistic understanding of this link between growth and vulnerability. I will test the main hypothesis that mechanisms that boost neuroplasticity promote adaptation to a dynamic environment, but at the cost of increased risk of psychopathology if exposed to a combination of genetic and environmental triggers. To this end I will utilize cutting-edge longitudinal brain imaging, electrophysiology, rich cognitive and clinical data, immune markers, gene expression and genetics. I will leverage on massive imaging data (n>40,000) and novel tools to increase power and generalizability and improve brain- and gene-based predictions of complex traits. Aiming to help resolving one of the modern day enigmas, BRAINMINT is a pioneering and high risk/high gain effort to find mechanisms of brain plasticity that support and harm the brain.

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The information about "BRAINMINT" are provided by the European Opendata Portal: CORDIS opendata.

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