Opendata, web and dolomites

ImmunoStem SIGNED

Dissecting and Overcoming Innate Immune Barriers for Therapeutically Efficient Hematopoietic Stem Cell Gene Engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ImmunoStem project word cloud

Explore the words cloud of the ImmunoStem project. It provides you a very rough idea of what is the project "ImmunoStem" about.

pathogen    lentiviral    platforms    hampering    nucleic    stem    genetic    cells    editing    hematopoietic    thorough    recognition    doses    engineering    completion    builds    potently    direct    single    trials    culture    edge    implications    mechanisms    nevertheless    human    disorders    outcomes    successful    antiviral    tip    transfer    viral    mere    efficient    technologies    fight    diseases    hsc    sensors    broad    innovative    innate    crosstalk    levels    components    restrict    iceberg    manipulating    counteract    modification    sustainable    potentially    therapy    vectors    paradigms    progress    prolonged    immune    sensing    gene    hurdle    primitive    blocks    clinically    ground    efficiencies    cutting    mitigate    effectors    autoimmune    clinical    breaking    acid    instruct    discovered    ex    manipulation    action    variability    vivo    cell    prevent    broadly    molecules    compartment    host    exportable    expose    plethora    therapies    efficiency    first    infectious    significantly    individual    vector    small   

Project "ImmunoStem" data sheet

The following table provides information about the project.

Coordinator
OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙994˙375 €
 EC max contribution 1˙994˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 1˙994˙375.00

Map

 Project objective

The low gene manipulation efficiency of human hematopoietic stem cells (HSC) remains a major hurdle for sustainable and broad clinical application of innovative therapies for a wide range of disorders. Indeed, high vector doses and prolonged ex vivo culture are still required for clinically relevant levels of gene transfer even with the most established lentiviral vector-based delivery platforms. Current and emerging gene transfer and editing technologies expose HSC to components potentially recognized by host antiviral factors and nucleic acid sensors that likely restrict their genetic engineering and contribute to broad individual variability in clinical outcomes observed in recent gene therapy trials. Nevertheless, specific effectors are yet to be identified in HSC. We have recently identified an antiviral factor that potently blocks gene transfer in HSC and have discovered small molecules that efficiently counteract it. This is the first example of how manipulating a single host factor can significantly impact gene transfer efficiencies in HSC but likely represents the mere tip of the iceberg of the plethora of innate sensing mechanisms potentially hampering genetic manipulation of this primitive cell compartment. This proposal aims to identify the antiviral factors and innate sensing pathways that prevent efficient modification of HSC and to mitigate their effects using methods developed through a thorough understanding of their mechanisms of action. My approach builds on the innovative concept that understanding the crosstalk between HSC and viral vectors will instruct us on which immune sensors and effectors to avoid and how, with direct implications for all gene engineering technologies. Successful completion of this project will deliver broadly exportable novel paradigms of innate pathogen recognition that will allow ground-breaking progress in the development of cutting-edge cell and gene therapies and to fight infectious and autoimmune diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNOSTEM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNOSTEM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More  

TRUST (2018)

Truth and Semantics

Read More