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PRiSM SIGNED

Programming Sensory regulation of Metabolism

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PRiSM project word cloud

Explore the words cloud of the PRiSM project. It provides you a very rough idea of what is the project "PRiSM" about.

underlying    perinatal    goals    uncovering    basic    physiological    independent    dependent    origins    energy    correlates    glucose    mediate    unhealthy    subsequently    influence    roots    programming    regulatory    lifelong    altered    health    line    deficit    hormonal    behavior    behavioral    concert    developmental    physiology    innovative    imaging    mechanisms    sensory    discovery    complementary    environments    shed    critical    nutrition    diet    neuroscience    employ    mice    overarching    homeostasis    emerged    childhood    negatively    chemogenetics    insights    master    mediating    feeding    pleiotropic    autonomous    suggests    collectively    central    accumulating    nutritional    regulator    deciphering    metabolic    consists    framework    diabetes    impinge    fundamental    calcium    perception    context    light    stages    optogenetics    synergistic    vivo    metabolism    predisposed    diseases    regulation    precise    life    revealed    body    integrative    maternal    exact    obesity   

Project "PRiSM" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2024-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 1˙500˙000.00

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 Project objective

Sensory perception has recently emerged as a master regulator of integrative physiology and behavior, including feeding, by controlling fundamental and pleiotropic regulatory processes of energy and glucose homeostasis. Further, sensory perception is altered in obesity and type 2 diabetes, and childhood obesity correlates with early sensory deficit. Along this line, the discovery of the developmental origins of health and diseases revealed that metabolic diseases have recognized roots in the very early stages of life and can be predisposed to by changes in the perinatal hormonal and nutritional environments, such as occur in cases of maternal obesity and unhealthy diet. In this context, an accumulating body of evidence suggests that maternal health and nutrition could negatively impinge on the development of sensory perception, and subsequently, on the lifelong regulation of sensory-dependent control of metabolic, physiological, and behavioral regulatory processes. This innovative research program consists of four autonomous but complementary projects aimed at (1) deciphering the exact central regulatory processes mediating sensory control of feeding behavior and glucose homeostasis, (2) uncovering the influence of maternal health and nutrition on lifelong sensory regulation of metabolism, and (3) & (4) investigating two independent, yet synergistic, mechanisms that could mediate developmental programming of sensory metabolic regulation. This research program will employ a technology framework of physiological, behavioral, and developmental analyses in mice in concert with state-of-the-art systems neuroscience approaches, including optogenetics, chemogenetics, and in vivo calcium imaging. Collectively, the overarching goals of this research program are to provide new insights into the precise regulatory processes of sensory metabolic regulation and to shed light on critical basic mechanisms underlying the developmental programming of metabolic diseases.

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The information about "PRISM" are provided by the European Opendata Portal: CORDIS opendata.

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