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FUSEDESIGN SIGNED

Model-guided design of a stabilized pre-fusion class III viral fusogen, rabies virus glycoprotein

Total Cost €

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EC-Contrib. €

0

Partnership

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 FUSEDESIGN project word cloud

Explore the words cloud of the FUSEDESIGN project. It provides you a very rough idea of what is the project "FUSEDESIGN" about.

herpesvirus    academic    forms    discipline    trimeric    herpesviruses    generation    model    certain    receptors    reported    skill    biochemistry    fusogens    cutting    tractable    data    structure    virus    glycoproteins    models    animals    antiviral    fusion    form    antibodies    structural    exposure    world    pathogens    designed    stability    notably    human    subunit    immunology    critical    enveloped    fellowship    rabies    vaccinology    structures    stabilization    interaction    insights    cells    candidates    glycoprotein    equip    translational    expressed    health    protein    viruses    conserved    truly    55    departments    contribution    stabilized    rvg    mutations    fatal    immunogens    guide    post    fusogen    costly    neutralizing    prohibitively    clinically    researcher    kills    interventions    training    quality    antigenically    stabilise    stabilize    mouse    vaccines    cumbersome    mutants    combination    vaccine    transiently    demand    biology    public    homology    class    unusual    mammalian    computational    centre    people    billions    host    molecular    spanning    guided    immunologically    position    combining    structurally    edge   

Project "FUSEDESIGN" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 224˙933.00

Map

 Project objective

This proposal aims to stabilize the pre-fusion form of rabies virus glycoprotein (RVG), the most structurally-tractable clinically-relevant class III fusogen by combining computational biology, immunology, and structural biology. Rabies virus is fatal; it kills 55,000 people each year and costs billions to control it in animals. Current human rabies vaccines are cumbersome to use and prohibitively costly, thus there is demand for a new generation of rabies vaccines. Enveloped viruses’ fusion glycoproteins are important subunit vaccine candidates. Structure-guided stabilization of class I fusogens has been a major advance in vaccinology. Many major human pathogens have class III fusogens (notably, all herpesviruses and rabies virus): several post-fusion structures have been reported, but their antigenically critical pre-fusion forms have not been stabilized. A high-quality homology model of RVG will guide design of mutations to stabilise the trimeric pre-fusion protein. Designed mutants will be transiently expressed in mammalian cells, selected for stability, and characterized immunologically. Lead candidates will be used as immunogens in mouse models and in structural studies. These data will guide design of improved rabies vaccines, and provide insights into RVG’s interaction with neutralizing antibodies and host receptors. Certain structural elements are conserved across class III fusogens, and so the approach may lead towards stabilization of herpesvirus fusogens. The fellowship will be based between two departments at a world-class host institution. Together, they will offer the Researcher an unusual combination of exposure to both cutting-edge molecular biochemistry and Europe’s leading academic centre for translational vaccine development. This unique training will equip the Researcher with a truly discipline-spanning skill set and position her to make a leading contribution to the development of novel antiviral interventions and public health.

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