Opendata, web and dolomites

RoBE SIGNED

Study of the role of BANK1 in antibody production and antibody-independent functions of B cells in SLE

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 RoBE project word cloud

Explore the words cloud of the RoBE project. It provides you a very rough idea of what is the project "RoBE" about.

switch    regulate    function    plays    drives    atac    pro    cytokine    independent    hyperactivation    recombination    protein    mechanisms    antigens    effector    women    flow    hypothesize    mass    tlr7    molecular    signaling    class    deep    absence    poorly    participation    identification    exert    circulating    activation    cytometry    underlying    inflammatory    systemic    examine    transcription    antibodies    assay    sle    chromatin    suggest    model    transposase    therapeutic    differentiation    nuclear    data    mediator    aberrant    seq    life    rna    igg    disease    incurable    functions    reported    acid    avenues    mice    primarily    threatening    generation    total    sequencing    chip    regulates    igg2c    followed    autoimmune    pathogenesis    antibody    scaffold    ed    mechanism    cells    immunoprecipitation    mouse    cell    self    autoantibodies    previously    erythematosus    exaggerated    accessible    pathogenic    bank1    susceptible    roles    understand    cytokines    ankyrin    lupus   

Project "RoBE" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD 

Organization address
address: AVENIDA AMERICO VESPUCIO 15 EDIF S2
city: SEVILLA
postcode: 41092
website: www.juntadeandalucia.es/fundacionprogresoysalud

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 259˙398 €
 EC max contribution 259˙398 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-09-16   to  2022-10-21

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD ES (SEVILLA) coordinator 259˙398.00

Map

 Project objective

Systemic Lupus Erythematosus (SLE, Lupus) is a life-threatening and incurable autoimmune disease that affects primarily women, its pathogenesis is related with an exaggerated B cells activation that results both in the generation of antibodies against self-nuclear acid antigens and in the generation of subsets of B cells that can exert antibody-independent roles in Lupus. However, the mechanisms that regulate aberrant B cell functions are poorly understood. In this project, we propose to investigate the role of the B cell scaffold protein with ankyrin repeats 1 (BANK1) in the B cell activation signaling pathways in a mouse model of Lupus. We have previously reported that the absence of BANK1 signaling in mice susceptible to Lupus resulted in the reduction of the activation of B cells, circulating total IgG2c and IgG autoantibodies, pro-inflammatory cytokines, and transcription factors related with TLR7 activation. Our data suggest that BANK1 is an important mediator of B cell hyperactivation. We hypothesize that BANK1 plays an important role in B cell signaling affecting their activation and effector functions in Lupus, however we do not fully understand yet the mechanism behind the function of BANK1. Our specific aims are: 1) to define how BANK1 signaling drives class switch recombination, 2) to determine the mechanism by which BANK1 regulates the cytokine production in B cells, and 3) to examine the participation of BANK1 signaling in the differentiation of pathogenic B cell subsets. To accomplish our objectives, we will use flow and mass cytometry, RNA-based next-generation sequencing (RNA-seq) analysis, the assay for transposase-accessible chromatin followed by deep sequencing (ATAC-seq), and a chromatin immunoprecipitation (ChIP) assay. We expect that the results of these studies will help to understand the molecular mechanism underlying the pathogenic B cell response in Lupus and will lead to identification of new avenues for therapeutic development.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ROBE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ROBE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

TOPOCIRCUS (2019)

Simulations of Topological Phases in Superconducting Circuits

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More