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RoBE SIGNED

Study of the role of BANK1 in antibody production and antibody-independent functions of B cells in SLE

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RoBE project word cloud

Explore the words cloud of the RoBE project. It provides you a very rough idea of what is the project "RoBE" about.

disease    exaggerated    molecular    mediator    pro    antigens    underlying    model    threatening    transposase    systemic    followed    ankyrin    functions    autoantibodies    cytometry    switch    antibody    self    previously    bank1    flow    roles    function    class    plays    exert    antibodies    understand    autoimmune    chip    tlr7    scaffold    drives    signaling    examine    assay    primarily    total    pathogenesis    deep    independent    igg    therapeutic    reported    accessible    atac    susceptible    avenues    acid    cytokine    generation    aberrant    lupus    cells    igg2c    suggest    mouse    regulate    life    ed    inflammatory    nuclear    recombination    identification    cell    incurable    data    mechanisms    mice    activation    hyperactivation    differentiation    mechanism    seq    effector    protein    pathogenic    sequencing    hypothesize    erythematosus    participation    rna    mass    sle    immunoprecipitation    chromatin    regulates    absence    poorly    circulating    cytokines    transcription    women   

Project "RoBE" data sheet

The following table provides information about the project.

Coordinator
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD 

Organization address
address: AVENIDA AMERICO VESPUCIO 15 EDIF S2
city: SEVILLA
postcode: 41092
website: www.juntadeandalucia.es/fundacionprogresoysalud

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 259˙398 €
 EC max contribution 259˙398 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-09-16   to  2022-10-21

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD ES (SEVILLA) coordinator 259˙398.00

Map

 Project objective

Systemic Lupus Erythematosus (SLE, Lupus) is a life-threatening and incurable autoimmune disease that affects primarily women, its pathogenesis is related with an exaggerated B cells activation that results both in the generation of antibodies against self-nuclear acid antigens and in the generation of subsets of B cells that can exert antibody-independent roles in Lupus. However, the mechanisms that regulate aberrant B cell functions are poorly understood. In this project, we propose to investigate the role of the B cell scaffold protein with ankyrin repeats 1 (BANK1) in the B cell activation signaling pathways in a mouse model of Lupus. We have previously reported that the absence of BANK1 signaling in mice susceptible to Lupus resulted in the reduction of the activation of B cells, circulating total IgG2c and IgG autoantibodies, pro-inflammatory cytokines, and transcription factors related with TLR7 activation. Our data suggest that BANK1 is an important mediator of B cell hyperactivation. We hypothesize that BANK1 plays an important role in B cell signaling affecting their activation and effector functions in Lupus, however we do not fully understand yet the mechanism behind the function of BANK1. Our specific aims are: 1) to define how BANK1 signaling drives class switch recombination, 2) to determine the mechanism by which BANK1 regulates the cytokine production in B cells, and 3) to examine the participation of BANK1 signaling in the differentiation of pathogenic B cell subsets. To accomplish our objectives, we will use flow and mass cytometry, RNA-based next-generation sequencing (RNA-seq) analysis, the assay for transposase-accessible chromatin followed by deep sequencing (ATAC-seq), and a chromatin immunoprecipitation (ChIP) assay. We expect that the results of these studies will help to understand the molecular mechanism underlying the pathogenic B cell response in Lupus and will lead to identification of new avenues for therapeutic development.

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The information about "ROBE" are provided by the European Opendata Portal: CORDIS opendata.

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