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RNA-Rep SIGNED

Repeating cycles of chemically-driven RNA replication within model protocells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RNA-Rep project word cloud

Explore the words cloud of the RNA-Rep project. It provides you a very rough idea of what is the project "RNA-Rep" about.

amplification    yield    darwinian    evolution    bilayer    amplify    partial    stochastic    transition    kinetically    renewed    me    duplex    replicated    monomers    induce    encoded    rounds    multidisciplinary    single    onset    subsequent    unexplored    strength    emergence    re    absence    unsolved    fraction    cycles    strands    chemistry    optimise    extensive    separated    put    rna    lipid    science    biochemistry    temperatures    annealing    structures    separation    simplistic    impermeability    enzymatic    nucleic    nucleotides    innovative    combines    slow    melting    separate    inhibiting    enzymes    give    biology    chemically    chemical    feeding    critical    training    membranes    template    ultimately    stage    solution    power    biophysics    excellent    melted    synthesis    recover    effort    copying    genetically    expertise    defects    protocellular    deciphering    strand    organic    leakage    stand    temperature    compartments    repeated    cooling    place    activated    heating    replication    containing    outcompetes    membrane    prebiotic    situ    acids    original    supramolecular    oligo    permeable    living    physically    denatured   

Project "RNA-Rep" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 224˙933.00

Map

 Project objective

Deciphering how nucleic acids replicated in the absence of genetically encoded enzymes is of critical importance to understanding the onset of Darwinian evolution. While much effort has been put into developing chemically-driven copying of RNA exploiting activated monomers, many unsolved issues stand in the way of achieving repeated cycles of non-enzymatic RNA replication. Non-enzymatic copying of a template strand results in the formation of an RNA duplex, which must then be denatured in order for subsequent rounds of replication to take place. Although RNA strands can be separated by heating, re-annealing kinetically outcompetes slow non-enzymatic copying, thus inhibiting RNA amplification. One unexplored solution to this problem is to physically separate melted strands of RNA so that re-annealing is not possible. Since all known living systems exploit lipid membranes, we propose to investigate whether protocellular compartments can facilitate the emergence of simplistic chemical systems that amplify RNA. Specifically, high temperatures are known to induce both RNA strand separation and bilayer defects, ultimately allowing for the partial leakage of RNA. If the transition temperature of the lipid membrane is higher than the melting temperature of the RNA, then subsequent slow cooling would recover the original impermeability of the membrane and give rise to a fraction of protocellular structures containing stochastic numbers of single RNA strands. At this stage, feeding with permeable activated short (oligo)nucleotides would lead to renewed copying of RNA. This highly original and multidisciplinary project combines the strength of organic and supramolecular chemistry to optimise prebiotic compartments with the power of in situ non-enzymatic RNA biochemistry to yield a project of excellent, innovative science that will exploit my expertise in protocellular systems while providing me extensive training in organic synthesis, chemical biology and biophysics.

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The information about "RNA-REP" are provided by the European Opendata Portal: CORDIS opendata.

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