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RNA-Rep SIGNED

Repeating cycles of chemically-driven RNA replication within model protocells

Total Cost €

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EC-Contrib. €

0

Partnership

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 RNA-Rep project word cloud

Explore the words cloud of the RNA-Rep project. It provides you a very rough idea of what is the project "RNA-Rep" about.

separation    biochemistry    emergence    separate    replicated    recover    stochastic    heating    subsequent    give    enzymes    living    denatured    onset    synthesis    lipid    annealing    organic    stage    defects    unsolved    acids    rounds    supramolecular    physically    put    duplex    stand    place    darwinian    solution    renewed    membrane    strand    fraction    training    permeable    science    single    melting    bilayer    biophysics    absence    combines    deciphering    strength    impermeability    amplification    unexplored    prebiotic    yield    multidisciplinary    rna    situ    power    optimise    me    outcompetes    leakage    temperatures    protocellular    critical    nucleotides    original    effort    copying    ultimately    separated    strands    re    amplify    nucleic    chemistry    template    repeated    melted    oligo    chemically    biology    innovative    slow    compartments    temperature    transition    inhibiting    kinetically    structures    cycles    chemical    monomers    membranes    partial    simplistic    excellent    encoded    expertise    induce    activated    replication    extensive    enzymatic    containing    evolution    genetically    feeding    cooling   

Project "RNA-Rep" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 224˙933.00

Map

 Project objective

Deciphering how nucleic acids replicated in the absence of genetically encoded enzymes is of critical importance to understanding the onset of Darwinian evolution. While much effort has been put into developing chemically-driven copying of RNA exploiting activated monomers, many unsolved issues stand in the way of achieving repeated cycles of non-enzymatic RNA replication. Non-enzymatic copying of a template strand results in the formation of an RNA duplex, which must then be denatured in order for subsequent rounds of replication to take place. Although RNA strands can be separated by heating, re-annealing kinetically outcompetes slow non-enzymatic copying, thus inhibiting RNA amplification. One unexplored solution to this problem is to physically separate melted strands of RNA so that re-annealing is not possible. Since all known living systems exploit lipid membranes, we propose to investigate whether protocellular compartments can facilitate the emergence of simplistic chemical systems that amplify RNA. Specifically, high temperatures are known to induce both RNA strand separation and bilayer defects, ultimately allowing for the partial leakage of RNA. If the transition temperature of the lipid membrane is higher than the melting temperature of the RNA, then subsequent slow cooling would recover the original impermeability of the membrane and give rise to a fraction of protocellular structures containing stochastic numbers of single RNA strands. At this stage, feeding with permeable activated short (oligo)nucleotides would lead to renewed copying of RNA. This highly original and multidisciplinary project combines the strength of organic and supramolecular chemistry to optimise prebiotic compartments with the power of in situ non-enzymatic RNA biochemistry to yield a project of excellent, innovative science that will exploit my expertise in protocellular systems while providing me extensive training in organic synthesis, chemical biology and biophysics.

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The information about "RNA-REP" are provided by the European Opendata Portal: CORDIS opendata.

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