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Ribosomal frameshifts as a novel mechanism to control RNA turnover in stress

Total Cost €


EC-Contrib. €






 TERMINATOR project word cloud

Explore the words cloud of the TERMINATOR project. It provides you a very rough idea of what is the project "TERMINATOR" about.

fire    ultimately    codons    ribosomal    concentrations    cells    overcoming    previously    mechanisms    human    modulation    5pseq    cellular    paramount    adapt    software    yeast    cross    degradation    frameshifts    containing    homeostasis    occurring    eliminates    gene    datasets    maintenance    mediated    telomere    opens    manner    translation    rf    environmental    accumulated    tested    limiting    host    technological    expand    transcripts    surveillance    regulated    transcription    serve    adaptability    decay    sense    environment    pool    explore    existence    premature    termination    stress    induce    preliminary    abundance    demonstrated    talk    aging    regulation    ptc    erroneous    mrna    mechanism    lab    fast    coupling    dependent    signals    composition    regulates    ptcs    suggesting    nonsense    changing    cell    expression    nature    performing    interconnection    nmd    community    window    rna    functional    maintaining    turnover    suggests   

Project "TERMINATOR" data sheet

The following table provides information about the project.


Organization address
address: Nobels Vag 5
postcode: 17177

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 191˙852.00


 Project objective

Modulation of gene expression is key for maintaining cellular homeostasis in the changing environment. It is achieved through controlling the processes of transcription and RNA degradation that ultimately affect abundance and composition of the mRNA pool. Emerging evidence suggests that the pathways of RNA surveillance and degradation are of paramount importance for fast adaptation of gene expression to stress. One of the most studied mechanisms controlling RNA turnover is nonsense-mediated decay (NMD). It eliminates erroneous transcripts containing premature termination codons (PTC), and also regulates expression of functional transcripts in condition-dependent manner. Recently, my host lab has demonstrated existence of widespread coupling between mRNA decay and translation. This opens a new window for translation dependent regulation of RNA turnover. Specifically, recent studies show that ribosomal frameshifts (RF) occurring during translation induce PTCs and fire NMD response. Preliminary evidence from the host lab suggests that RF is regulated upon stress and could serve as a new mechanism to sense environmental signals and adapt mRNA concentrations. It is yet to be tested if such a regulation is of widespread nature in the cell. The main goal of this project is to investigate stress-dependent regulation of ribosomal frameshifts and their role in RNA turnover. The 5PSeq approach developed in the host lab will allow for performing high-scale analysis in yeast and human cells, and overcoming existing technological challenges previously limiting research in the field. This project will also explore the cross-talk between RNA turnover and telomere maintenance in cellular response to stress and aging. This will expand the accumulated evidence suggesting interconnection of RNA turnover with other processes involved in cellular adaptability. Finally, I will develop a software package for analysis of RNA degradation datasets that can be used by the research community.

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The information about "TERMINATOR" are provided by the European Opendata Portal: CORDIS opendata.

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