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TERMINATOR SIGNED

Ribosomal frameshifts as a novel mechanism to control RNA turnover in stress

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TERMINATOR project word cloud

Explore the words cloud of the TERMINATOR project. It provides you a very rough idea of what is the project "TERMINATOR" about.

nonsense    mechanisms    software    demonstrated    human    maintenance    5pseq    adapt    cells    preliminary    rf    dependent    rna    regulated    lab    signals    transcription    technological    explore    environmental    erroneous    cell    interconnection    paramount    community    aging    sense    regulation    occurring    adaptability    window    codons    induce    containing    previously    transcripts    suggesting    talk    ultimately    datasets    nmd    cross    changing    regulates    modulation    environment    overcoming    composition    eliminates    fire    suggests    maintaining    expression    performing    host    expand    nature    abundance    turnover    gene    coupling    ribosomal    decay    accumulated    ptc    limiting    homeostasis    opens    yeast    surveillance    fast    mrna    premature    cellular    functional    telomere    mechanism    existence    mediated    translation    termination    tested    frameshifts    concentrations    ptcs    pool    manner    degradation    stress    serve   

Project "TERMINATOR" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 191˙852.00

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 Project objective

Modulation of gene expression is key for maintaining cellular homeostasis in the changing environment. It is achieved through controlling the processes of transcription and RNA degradation that ultimately affect abundance and composition of the mRNA pool. Emerging evidence suggests that the pathways of RNA surveillance and degradation are of paramount importance for fast adaptation of gene expression to stress. One of the most studied mechanisms controlling RNA turnover is nonsense-mediated decay (NMD). It eliminates erroneous transcripts containing premature termination codons (PTC), and also regulates expression of functional transcripts in condition-dependent manner. Recently, my host lab has demonstrated existence of widespread coupling between mRNA decay and translation. This opens a new window for translation dependent regulation of RNA turnover. Specifically, recent studies show that ribosomal frameshifts (RF) occurring during translation induce PTCs and fire NMD response. Preliminary evidence from the host lab suggests that RF is regulated upon stress and could serve as a new mechanism to sense environmental signals and adapt mRNA concentrations. It is yet to be tested if such a regulation is of widespread nature in the cell. The main goal of this project is to investigate stress-dependent regulation of ribosomal frameshifts and their role in RNA turnover. The 5PSeq approach developed in the host lab will allow for performing high-scale analysis in yeast and human cells, and overcoming existing technological challenges previously limiting research in the field. This project will also explore the cross-talk between RNA turnover and telomere maintenance in cellular response to stress and aging. This will expand the accumulated evidence suggesting interconnection of RNA turnover with other processes involved in cellular adaptability. Finally, I will develop a software package for analysis of RNA degradation datasets that can be used by the research community.

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The information about "TERMINATOR" are provided by the European Opendata Portal: CORDIS opendata.

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