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NanoMechShape SIGNED

Molecular control of actin network architecture and mechanics during cell shape changes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NanoMechShape project word cloud

Explore the words cloud of the NanoMechShape project. It provides you a very rough idea of what is the project "NanoMechShape" about.

regulated    contractile    investigations    electron    explore    behaviors    nanomechshape    truly    first    gap    furrow    stem    cell    architecture    difficulty    categories    mitosis    gradient    lamellipodia    bridging    comprise    elusive    crosstalk    organisation    pathologies    establishment    morphology    resolution    integrating    multidisciplinary    determinants    underlying    probing    architectural    interdisciplinary    exemplar    ing    heart    ingression    deformations    thin    mechanisms    contractions    fate    unveil    morphogenesis    cytokinetic    networks    spreading    network    molecular    biology    transitions    regulatory    forces    embryonic    filopodia    principles    nanoscale    microscopy    understand    shape    fall    rounded    physiology    driving    compare    cortex    fundamental    regulation    tension    cortical    actin    primary    cells    membrane    animal    deregulation    differentiation    mouse    systematically    physics    paving    precise    super   

Project "NanoMechShape" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙943˙071 €
 EC max contribution 1˙943˙071 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙943˙071.00

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 Project objective

Precise control of shape is key to cell physiology, and cell shape deregulation is at the heart of many pathologies. As cell morphology is controlled by forces, studies integrating physics with biology are required to truly understand morphogenesis. NanoMechShape will take such an interdisciplinary approach to investigate the regulation of animal cell shape. In animal cells, actin networks are the primary determinants of shape. Most cell shape changes fall into two categories: 1) those driven by contractions of the actin cortex, a thin network underlying the membrane in rounded cells; and 2) those resulting from transitions between the cortex and other actin networks, such as lamellipodia and filopodia. To understand cell deformations, it is thus essential to understand the regulation of cortex contractile tension and the mechanisms controlling transitions in actin architecture. NanoMechShape will comprise three aims. First, we will explore how cortex tension is regulated. We will focus on the role of cortex architecture, which remains elusive due to the difficulty in probing the organisation of the thin cortical network. We will unveil cortex architecture using super-resolution and electron microscopy, and systematically investigate how nanoscale architectural features affect tension. Second, we will explore how the identified regulatory mechanisms contribute to the establishment of a cortical tension gradient. We will focus on the gradient driving cytokinetic furrow ingression, an exemplar tension-driven shape change. Third, we will investigate transitions in actin architecture underlying cell spreading. We will compare spreading at the end of mitosis and during differentiation of mouse embryonic stem cells, paving the way to investigations of the crosstalk between cell shape and fate. By bridging a fundamental gap between molecular processes and cell-scale behaviors, our multidisciplinary study will unveil some of the fundamental principles of cell morphogenesis.

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The information about "NANOMECHSHAPE" are provided by the European Opendata Portal: CORDIS opendata.

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