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NanoMechShape SIGNED

Molecular control of actin network architecture and mechanics during cell shape changes

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoMechShape project word cloud

Explore the words cloud of the NanoMechShape project. It provides you a very rough idea of what is the project "NanoMechShape" about.

gradient    pathologies    establishment    embryonic    nanomechshape    primary    contractile    elusive    regulated    rounded    compare    tension    exemplar    driving    integrating    fall    morphology    cell    thin    fundamental    resolution    molecular    electron    gap    membrane    fate    contractions    precise    furrow    crosstalk    multidisciplinary    truly    underlying    ingression    difficulty    regulation    morphogenesis    cortical    cortex    shape    animal    actin    understand    heart    lamellipodia    first    networks    physiology    deformations    differentiation    cells    paving    determinants    forces    microscopy    explore    super    probing    systematically    stem    comprise    spreading    bridging    biology    unveil    transitions    interdisciplinary    cytokinetic    mechanisms    nanoscale    mitosis    mouse    architecture    network    deregulation    behaviors    principles    architectural    ing    organisation    categories    investigations    physics    regulatory    filopodia   

Project "NanoMechShape" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙943˙071 €
 EC max contribution 1˙943˙071 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 1˙943˙071.00

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 Project objective

Precise control of shape is key to cell physiology, and cell shape deregulation is at the heart of many pathologies. As cell morphology is controlled by forces, studies integrating physics with biology are required to truly understand morphogenesis. NanoMechShape will take such an interdisciplinary approach to investigate the regulation of animal cell shape. In animal cells, actin networks are the primary determinants of shape. Most cell shape changes fall into two categories: 1) those driven by contractions of the actin cortex, a thin network underlying the membrane in rounded cells; and 2) those resulting from transitions between the cortex and other actin networks, such as lamellipodia and filopodia. To understand cell deformations, it is thus essential to understand the regulation of cortex contractile tension and the mechanisms controlling transitions in actin architecture. NanoMechShape will comprise three aims. First, we will explore how cortex tension is regulated. We will focus on the role of cortex architecture, which remains elusive due to the difficulty in probing the organisation of the thin cortical network. We will unveil cortex architecture using super-resolution and electron microscopy, and systematically investigate how nanoscale architectural features affect tension. Second, we will explore how the identified regulatory mechanisms contribute to the establishment of a cortical tension gradient. We will focus on the gradient driving cytokinetic furrow ingression, an exemplar tension-driven shape change. Third, we will investigate transitions in actin architecture underlying cell spreading. We will compare spreading at the end of mitosis and during differentiation of mouse embryonic stem cells, paving the way to investigations of the crosstalk between cell shape and fate. By bridging a fundamental gap between molecular processes and cell-scale behaviors, our multidisciplinary study will unveil some of the fundamental principles of cell morphogenesis.

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The information about "NANOMECHSHAPE" are provided by the European Opendata Portal: CORDIS opendata.

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