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BIOVIB SIGNED

Electric Interactions and Structural Dynamics of Hydrated Biomolecules Mapped by Ultrafast Vibrational Probes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BIOVIB project word cloud

Explore the words cloud of the BIOVIB project. It provides you a very rough idea of what is the project "BIOVIB" about.

molecules    fundamental    transmembrane    introduces    aqueous    channels    presently    fluctuating    strength    stabilizing    biomolecules    genuine    unravel    interface    resolved    atmospheres    forces    local    holds    structure    absolute    function    solvated    retarded    ion    time    site    nanometer    scales    folding    secondary    biological    influenced    length    covalent    outer    single    instantaneous    spatial    breaking    interactions    magnesium    dynamics    fluctuation    excitations    sensitive    composition    calibrates    ray    versus    quantitative    stranded    rhodopsins    electric    mechanisms    atmosphere    noninvasive    theoretical    strengths    molecular    scattering    hydration    tertiary    gives    ground    thz    definition    sub    charge    terahertz    scientific    frequencies    probes    contributions    separated    channel    act    vibrational    structures    dynamically    water    dipolar    shell    separates    mapping    multidimensional    ions    environment    double    external    shift    paradigm    barely    exist    direct    interplay    stark    bound    dna    rna    levels    milliseconds    spectroscopy    experiments    discerning    structurally    biomolecular   

Project "BIOVIB" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSVERBUND BERLIN EV 

Organization address
address: RUDOWER CHAUSSEE 17
city: BERLIN
postcode: 12489
website: www.fv-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙330˙492 €
 EC max contribution 2˙330˙492 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSVERBUND BERLIN EV DE (BERLIN) coordinator 2˙330˙492.00

Map

 Project objective

Biomolecules exist in an aqueous environment of dipolar water molecules and solvated ions. Their structure and biological function are strongly influenced by electric interactions with the fluctuating water shell and ion atmosphere. Understanding such interactions at the molecular level is a major scientific challenge; presently, their strengths, spatial range and interplay with other non-covalent interactions are barely known. Going far beyond existing methods, this project introduces the new paradigm of a direct time-resolved mapping of molecular electric forces on sub-nanometer length scales and at the genuine terahertz (THz) fluctuation frequencies. Vibrational excitations of biomolecules at the interface to the water shell act as sensitive noninvasive probes of charge dynamics and local electric fields. The new method of time resolved vibrational Stark shift spectroscopy with THz external fields calibrates vibrational frequencies as a function of absolute field strength and separates instantaneous from retarded environment fields. Based on this knowledge, multidimensional vibrational spectroscopy gives quantitative insight in the biomolecular response to electric fields, discerning contributions from water and ions in a site-specific way. The experiments and theoretical analysis focus on single- and double-stranded RNA and DNA structures at different hydration levels and with ion atmospheres of controlled composition, structurally characterized by x-ray scattering. As a ground-breaking open problem, the role of magnesium and other ions in RNA structure definition and folding will be addressed by following RNA folding processes with vibrational probes up to milliseconds. The impact of site-bound versus outer ions will be dynamically separated to unravel mechanisms stabilizing secondary and tertiary RNA structures. Beyond RNA research, the present approach holds strong potential for fundamental insight in transmembrane ion channels and channel rhodopsins.

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The information about "BIOVIB" are provided by the European Opendata Portal: CORDIS opendata.

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