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BIOVIB SIGNED

Electric Interactions and Structural Dynamics of Hydrated Biomolecules Mapped by Ultrafast Vibrational Probes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BIOVIB project word cloud

Explore the words cloud of the BIOVIB project. It provides you a very rough idea of what is the project "BIOVIB" about.

sensitive    gives    excitations    covalent    barely    scales    levels    thz    absolute    interplay    experiments    milliseconds    resolved    introduces    channels    channel    unravel    folding    terahertz    mapping    molecules    noninvasive    multidimensional    instantaneous    direct    strengths    mechanisms    shift    fluctuating    ground    theoretical    ion    nanometer    atmospheres    genuine    tertiary    interface    fluctuation    separates    outer    spatial    double    scientific    breaking    probes    atmosphere    local    ions    rhodopsins    dynamics    structure    strength    stranded    ray    separated    influenced    site    holds    charge    retarded    water    function    discerning    scattering    sub    frequencies    paradigm    contributions    external    biomolecules    definition    exist    biomolecular    transmembrane    dipolar    calibrates    structurally    hydration    molecular    dna    secondary    fundamental    structures    biological    time    vibrational    solvated    electric    single    dynamically    stabilizing    aqueous    forces    environment    magnesium    stark    versus    bound    spectroscopy    presently    rna    quantitative    shell    composition    act    interactions    length   

Project "BIOVIB" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSVERBUND BERLIN EV 

Organization address
address: RUDOWER CHAUSSEE 17
city: BERLIN
postcode: 12489
website: www.fv-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙330˙492 €
 EC max contribution 2˙330˙492 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSVERBUND BERLIN EV DE (BERLIN) coordinator 2˙330˙492.00

Map

 Project objective

Biomolecules exist in an aqueous environment of dipolar water molecules and solvated ions. Their structure and biological function are strongly influenced by electric interactions with the fluctuating water shell and ion atmosphere. Understanding such interactions at the molecular level is a major scientific challenge; presently, their strengths, spatial range and interplay with other non-covalent interactions are barely known. Going far beyond existing methods, this project introduces the new paradigm of a direct time-resolved mapping of molecular electric forces on sub-nanometer length scales and at the genuine terahertz (THz) fluctuation frequencies. Vibrational excitations of biomolecules at the interface to the water shell act as sensitive noninvasive probes of charge dynamics and local electric fields. The new method of time resolved vibrational Stark shift spectroscopy with THz external fields calibrates vibrational frequencies as a function of absolute field strength and separates instantaneous from retarded environment fields. Based on this knowledge, multidimensional vibrational spectroscopy gives quantitative insight in the biomolecular response to electric fields, discerning contributions from water and ions in a site-specific way. The experiments and theoretical analysis focus on single- and double-stranded RNA and DNA structures at different hydration levels and with ion atmospheres of controlled composition, structurally characterized by x-ray scattering. As a ground-breaking open problem, the role of magnesium and other ions in RNA structure definition and folding will be addressed by following RNA folding processes with vibrational probes up to milliseconds. The impact of site-bound versus outer ions will be dynamically separated to unravel mechanisms stabilizing secondary and tertiary RNA structures. Beyond RNA research, the present approach holds strong potential for fundamental insight in transmembrane ion channels and channel rhodopsins.

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The information about "BIOVIB" are provided by the European Opendata Portal: CORDIS opendata.

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