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DECODE SIGNED

Decoding Context-Dependent Genetic Networks in vivo

Total Cost €

0

EC-Contrib. €

0

Partnership

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 DECODE project word cloud

Explore the words cloud of the DECODE project. It provides you a very rough idea of what is the project "DECODE" about.

tissues    tissue    combined    cas9    adapt    external    consequently    methodological    statistics    topology    analyzing    stimuli    principles    drosophila    knockout    evolutionary    theoretical    rigorously    cells    foundation    insights    profiling    conditional    networks    imaging    types    model    conceptual    multicellular    outstanding    regulatory    knockouts    million    thousand    computational    genomics    maps    molecular    unravel    transcriptome    perturbation    create    edge    circuits    kingdoms    decode    specification    coupled    function    fundamental    functional    cellular    organisms    plant    fate    division    perturbations    profiles    species    single    building    expression    genetics    predict    dependent    cell    phenotyping    crispr    animal    genetic    organism    repertoire    expertise    labor    organization    context    lay    powerful    groups    uncover    atlases    arabidopsis    resolution    architecture    experimental    biology    divergent    behavior    map    vivo    complementary    determinants   

Project "DECODE" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 280
city: HEIDELBERG
postcode: 69120
website: www.dkfz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 10˙625˙000 €
 EC max contribution 10˙625˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) coordinator 4˙042˙500.00
2    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 3˙770˙000.00
3    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 2˙812˙500.00

Map

 Project objective

The evolutionary success of multicellular organisms is based on the division of labor between cells. While some of the molecular determinants for cell fate specification have been identified, a fundamental understanding of which genetic activities are required in each cell of a developing tissue is still outstanding. The DECODE project will develop and apply leading-edge system genetics methods to Arabidopsis and Drosophila, two major model systems from the plant and animal kingdoms to decode context-dependent genetic networks in vivo. To achieve this, DECODE will bring together experimental and theoretical groups with complementary expertise in model organism genetics and cellular phenotyping, single-cell genomics, statistics and computational biology. Building on our combined expertise, we will create functional genetic maps using conditional CRISPR/Cas9-based single- and higher order knockout perturbations in vivo combined with single-cell expression profiling and imaging. Coupled with powerful computational analysis, this project will not only define, predict and rigorously test the unique genetic repertoire of each cell, but also unravel how genetic networks adapt their topology and function across cell types and external stimuli. With more than thousand conditional knockouts, characterized by several million single-cell transcriptome profiles and high-resolution imaging this project will create the largest single-cell perturbation map in any model organism and will provide fundamental insights into the genetic architecture of complex tissues. Analyzing two tissues with divergent organization and regulatory repertoire will enable us to uncover general principles in the genetic circuits controlling context dependent cell behavior. Consequently, we expect that the DECODE project in model organisms will lay the conceptual and methodological foundation for perturbation-based functional atlases in other tissues or species.

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The information about "DECODE" are provided by the European Opendata Portal: CORDIS opendata.

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