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DECODE SIGNED

Decoding Context-Dependent Genetic Networks in vivo

Total Cost €

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EC-Contrib. €

0

Partnership

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 DECODE project word cloud

Explore the words cloud of the DECODE project. It provides you a very rough idea of what is the project "DECODE" about.

single    foundation    organisms    organization    consequently    maps    adapt    context    cells    determinants    experimental    species    specification    tissues    circuits    biology    genetic    vivo    create    million    outstanding    genomics    expertise    cell    cellular    groups    theoretical    arabidopsis    types    topology    functional    drosophila    principles    organism    genetics    insights    division    animal    resolution    phenotyping    decode    architecture    perturbations    perturbation    fate    lay    coupled    map    atlases    crispr    methodological    expression    uncover    statistics    combined    dependent    conditional    unravel    function    computational    fundamental    kingdoms    evolutionary    complementary    predict    stimuli    profiling    repertoire    imaging    edge    behavior    cas9    networks    external    analyzing    building    model    tissue    powerful    thousand    transcriptome    conceptual    knockout    rigorously    regulatory    divergent    multicellular    profiles    knockouts    molecular    plant    labor   

Project "DECODE" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 280
city: HEIDELBERG
postcode: 69120
website: www.dkfz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 10˙625˙000 €
 EC max contribution 10˙625˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) coordinator 4˙042˙500.00
2    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 3˙770˙000.00
3    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 2˙812˙500.00

Map

 Project objective

The evolutionary success of multicellular organisms is based on the division of labor between cells. While some of the molecular determinants for cell fate specification have been identified, a fundamental understanding of which genetic activities are required in each cell of a developing tissue is still outstanding. The DECODE project will develop and apply leading-edge system genetics methods to Arabidopsis and Drosophila, two major model systems from the plant and animal kingdoms to decode context-dependent genetic networks in vivo. To achieve this, DECODE will bring together experimental and theoretical groups with complementary expertise in model organism genetics and cellular phenotyping, single-cell genomics, statistics and computational biology. Building on our combined expertise, we will create functional genetic maps using conditional CRISPR/Cas9-based single- and higher order knockout perturbations in vivo combined with single-cell expression profiling and imaging. Coupled with powerful computational analysis, this project will not only define, predict and rigorously test the unique genetic repertoire of each cell, but also unravel how genetic networks adapt their topology and function across cell types and external stimuli. With more than thousand conditional knockouts, characterized by several million single-cell transcriptome profiles and high-resolution imaging this project will create the largest single-cell perturbation map in any model organism and will provide fundamental insights into the genetic architecture of complex tissues. Analyzing two tissues with divergent organization and regulatory repertoire will enable us to uncover general principles in the genetic circuits controlling context dependent cell behavior. Consequently, we expect that the DECODE project in model organisms will lay the conceptual and methodological foundation for perturbation-based functional atlases in other tissues or species.

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The information about "DECODE" are provided by the European Opendata Portal: CORDIS opendata.

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