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Salmofish SIGNED

Tracing T3SS effectors in vivo during Salmonella infection in the zebrafish model

Total Cost €


EC-Contrib. €






 Salmofish project word cloud

Explore the words cloud of the Salmofish project. It provides you a very rough idea of what is the project "Salmofish" about.

context    bacteria    interaction    infections    scenario    infection    mice    always    innovative    unknown    encodes    strengthen    invasive    cytosol    experiments    monitoring    secretion    contributed    small    transparency    eukaryotic    larval    hosting    zebrafish    cell    stablish    manipulate    inside    boosting    dissect    rapid    tracking    sophisticated    molecular    once    laboratory    cellular    infectious    pathogen    biological    needles    scientific    t3ss    resolution    gram    mammalian    imaging    epithelial    size    bacterial    models    last    diseases    posibilities    enterica    proteins    decades    translocate    effectors    embryo    danio    type    localization    characterization    time    rerio    vertebrate    model    transduction    optical    live    cells    of    subcellular    advantage    identification    pathogenic    signal    negative    host    career    vivo    extrapolation    surrogate    vitro    salmonella    macrophages    infected    significantly    majority   

Project "Salmofish" data sheet

The following table provides information about the project.


Organization address
address: CALLE S. FERNANDO 4
postcode: 41004

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SEVILLA ES (SEVILLA) coordinator 172˙932.00


 Project objective

Type III secretion systems (T3SS) are sophisticated “molecular needles” that many pathogenic Gram-negative bacteria use to establish infection. Salmonella enterica encodes two T3SS that are able to translocate a number of proteins, called effectors, from bacteria to the cytosol of the infected eukaryotic cell. These proteins manipulate host signal transduction pathways and cellular processes to the pathogen’s advantage. During the last two decades, many studies have importantly contributed to the identification and characterization of many of these effectors. However, the subcellular localization, host target and biological role of an important number of them remain unknown. The majority of findings of T3SS effectors come from studies using surrogate in vitro models, like epithelial cells or macrophages. In these cases, the extrapolation of results to an in vivo scenario is not always possible. On the other hand, important mammalian models to study Salmonella infection, like mice, do not allow tracking the pathogen once inside its host. Here, we propose an innovative approach using the zebrafish (Danio rerio) as a relevant vertebrate model to dissect the biological role of Salmonella T3SS effectors during host infection. Zebrafish embryo model allow for rapid, non-invasive and real-time analysis of bacterial infections. We will take advantage of the small size and optical transparency of larval zebrafish for live-cell imaging of host-pathogen interaction experiments. This approach allows real-time cell-resolution monitoring of T3SS effectors. This will significantly improve our understanding of infectious diseases in an relevant in vivo context. This project not only will stablish a new in vivo model in the hosting laboratory and open new posibilities in the study of T3SS effectors, but also it will contribute to strengthen my previous experience boosting my future scientific career.

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The information about "SALMOFISH" are provided by the European Opendata Portal: CORDIS opendata.

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