Opendata, web and dolomites

Salmofish SIGNED

Tracing T3SS effectors in vivo during Salmonella infection in the zebrafish model

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Salmofish project word cloud

Explore the words cloud of the Salmofish project. It provides you a very rough idea of what is the project "Salmofish" about.

bacterial    infection    posibilities    infectious    signal    rapid    enterica    advantage    dissect    scenario    vitro    cell    experiments    pathogen    always    decades    career    encodes    mice    scientific    characterization    localization    pathogenic    eukaryotic    rerio    majority    infected    host    of    embryo    macrophages    surrogate    mammalian    molecular    last    cytosol    identification    size    models    optical    time    biological    cellular    diseases    bacteria    infections    larval    laboratory    significantly    negative    once    context    danio    proteins    transparency    inside    hosting    sophisticated    salmonella    tracking    gram    resolution    monitoring    interaction    invasive    translocate    unknown    manipulate    effectors    boosting    subcellular    vertebrate    zebrafish    cells    secretion    small    vivo    stablish    model    type    imaging    strengthen    live    needles    innovative    extrapolation    transduction    contributed    epithelial    t3ss   

Project "Salmofish" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SEVILLA 

Organization address
address: CALLE S. FERNANDO 4
city: SEVILLA
postcode: 41004
website: www.us.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SEVILLA ES (SEVILLA) coordinator 172˙932.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Type III secretion systems (T3SS) are sophisticated “molecular needles” that many pathogenic Gram-negative bacteria use to establish infection. Salmonella enterica encodes two T3SS that are able to translocate a number of proteins, called effectors, from bacteria to the cytosol of the infected eukaryotic cell. These proteins manipulate host signal transduction pathways and cellular processes to the pathogen’s advantage. During the last two decades, many studies have importantly contributed to the identification and characterization of many of these effectors. However, the subcellular localization, host target and biological role of an important number of them remain unknown. The majority of findings of T3SS effectors come from studies using surrogate in vitro models, like epithelial cells or macrophages. In these cases, the extrapolation of results to an in vivo scenario is not always possible. On the other hand, important mammalian models to study Salmonella infection, like mice, do not allow tracking the pathogen once inside its host. Here, we propose an innovative approach using the zebrafish (Danio rerio) as a relevant vertebrate model to dissect the biological role of Salmonella T3SS effectors during host infection. Zebrafish embryo model allow for rapid, non-invasive and real-time analysis of bacterial infections. We will take advantage of the small size and optical transparency of larval zebrafish for live-cell imaging of host-pathogen interaction experiments. This approach allows real-time cell-resolution monitoring of T3SS effectors. This will significantly improve our understanding of infectious diseases in an relevant in vivo context. This project not only will stablish a new in vivo model in the hosting laboratory and open new posibilities in the study of T3SS effectors, but also it will contribute to strengthen my previous experience boosting my future scientific career.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SALMOFISH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SALMOFISH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

MegaBiCycle (2019)

The role of megafauna in biogeochemical cycles and greenhouse gas fluxes: implications for climate and ecosystems throughout history

Read More  

TOPOCIRCUS (2019)

Simulations of Topological Phases in Superconducting Circuits

Read More