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Salmofish SIGNED

Tracing T3SS effectors in vivo during Salmonella infection in the zebrafish model

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Salmofish project word cloud

Explore the words cloud of the Salmofish project. It provides you a very rough idea of what is the project "Salmofish" about.

bacterial    scenario    transparency    imaging    small    monitoring    eukaryotic    optical    model    decades    invasive    proteins    larval    time    cells    posibilities    salmonella    live    translocate    infected    infections    mammalian    effectors    bacteria    hosting    infection    subcellular    infectious    macrophages    enterica    t3ss    vertebrate    once    surrogate    gram    context    localization    unknown    inside    negative    cytosol    manipulate    career    diseases    experiments    contributed    epithelial    transduction    interaction    embryo    extrapolation    encodes    molecular    pathogenic    models    significantly    identification    strengthen    mice    rerio    sophisticated    last    cell    danio    advantage    majority    resolution    stablish    cellular    host    dissect    needles    type    of    rapid    vivo    boosting    secretion    innovative    zebrafish    vitro    size    signal    pathogen    always    laboratory    scientific    characterization    tracking    biological   

Project "Salmofish" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SEVILLA 

Organization address
address: CALLE S. FERNANDO 4
city: SEVILLA
postcode: 41004
website: www.us.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SEVILLA ES (SEVILLA) coordinator 172˙932.00

Map

 Project objective

Type III secretion systems (T3SS) are sophisticated “molecular needles” that many pathogenic Gram-negative bacteria use to establish infection. Salmonella enterica encodes two T3SS that are able to translocate a number of proteins, called effectors, from bacteria to the cytosol of the infected eukaryotic cell. These proteins manipulate host signal transduction pathways and cellular processes to the pathogen’s advantage. During the last two decades, many studies have importantly contributed to the identification and characterization of many of these effectors. However, the subcellular localization, host target and biological role of an important number of them remain unknown. The majority of findings of T3SS effectors come from studies using surrogate in vitro models, like epithelial cells or macrophages. In these cases, the extrapolation of results to an in vivo scenario is not always possible. On the other hand, important mammalian models to study Salmonella infection, like mice, do not allow tracking the pathogen once inside its host. Here, we propose an innovative approach using the zebrafish (Danio rerio) as a relevant vertebrate model to dissect the biological role of Salmonella T3SS effectors during host infection. Zebrafish embryo model allow for rapid, non-invasive and real-time analysis of bacterial infections. We will take advantage of the small size and optical transparency of larval zebrafish for live-cell imaging of host-pathogen interaction experiments. This approach allows real-time cell-resolution monitoring of T3SS effectors. This will significantly improve our understanding of infectious diseases in an relevant in vivo context. This project not only will stablish a new in vivo model in the hosting laboratory and open new posibilities in the study of T3SS effectors, but also it will contribute to strengthen my previous experience boosting my future scientific career.

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The information about "SALMOFISH" are provided by the European Opendata Portal: CORDIS opendata.

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