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Salmofish SIGNED

Tracing T3SS effectors in vivo during Salmonella infection in the zebrafish model

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Salmofish project word cloud

Explore the words cloud of the Salmofish project. It provides you a very rough idea of what is the project "Salmofish" about.

cell    gram    localization    identification    advantage    unknown    surrogate    laboratory    infection    macrophages    inside    effectors    translocate    subcellular    eukaryotic    of    always    manipulate    zebrafish    size    larval    live    mice    imaging    contributed    host    signal    experiments    vitro    bacterial    decades    dissect    epithelial    last    optical    encodes    career    molecular    scientific    proteins    time    model    extrapolation    t3ss    type    significantly    monitoring    vertebrate    models    characterization    danio    secretion    bacteria    invasive    interaction    context    pathogen    cytosol    small    cells    posibilities    strengthen    sophisticated    enterica    majority    resolution    diseases    tracking    cellular    hosting    vivo    infected    infections    salmonella    rerio    embryo    boosting    scenario    transduction    mammalian    needles    rapid    pathogenic    biological    innovative    negative    once    infectious    stablish    transparency   

Project "Salmofish" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SEVILLA 

Organization address
address: CALLE S. FERNANDO 4
city: SEVILLA
postcode: 41004
website: www.us.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SEVILLA ES (SEVILLA) coordinator 172˙932.00

Map

 Project objective

Type III secretion systems (T3SS) are sophisticated “molecular needles” that many pathogenic Gram-negative bacteria use to establish infection. Salmonella enterica encodes two T3SS that are able to translocate a number of proteins, called effectors, from bacteria to the cytosol of the infected eukaryotic cell. These proteins manipulate host signal transduction pathways and cellular processes to the pathogen’s advantage. During the last two decades, many studies have importantly contributed to the identification and characterization of many of these effectors. However, the subcellular localization, host target and biological role of an important number of them remain unknown. The majority of findings of T3SS effectors come from studies using surrogate in vitro models, like epithelial cells or macrophages. In these cases, the extrapolation of results to an in vivo scenario is not always possible. On the other hand, important mammalian models to study Salmonella infection, like mice, do not allow tracking the pathogen once inside its host. Here, we propose an innovative approach using the zebrafish (Danio rerio) as a relevant vertebrate model to dissect the biological role of Salmonella T3SS effectors during host infection. Zebrafish embryo model allow for rapid, non-invasive and real-time analysis of bacterial infections. We will take advantage of the small size and optical transparency of larval zebrafish for live-cell imaging of host-pathogen interaction experiments. This approach allows real-time cell-resolution monitoring of T3SS effectors. This will significantly improve our understanding of infectious diseases in an relevant in vivo context. This project not only will stablish a new in vivo model in the hosting laboratory and open new posibilities in the study of T3SS effectors, but also it will contribute to strengthen my previous experience boosting my future scientific career.

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The information about "SALMOFISH" are provided by the European Opendata Portal: CORDIS opendata.

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