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PMSMatTrain SIGNED

Novel Biomaterial-based Device for the Treatment of Progressive MS- - An Integrated Pan- European Approach

Total Cost €

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EC-Contrib. €

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Partnership

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 PMSMatTrain project word cloud

Explore the words cloud of the PMSMatTrain project. It provides you a very rough idea of what is the project "PMSMatTrain" about.

manufacturing    medical    april    neuroprotection    characterised    evaluation    property    stem    commercialisation    utilise    signals    multiple    sclerosis    tested    device    hyaluronan    neuroprotective    quality    intellectual    weight    affairs    transferable    directed    policy    vivo    generate    modal    functionalised    drug    clinically    regulatory    recruited    mechanisms    pathophysiology    pmsmattrain    tool    basics    translation    smes    chronic    small    cross    ibudilast    training    cns    first    remyelination    silico    mass    release    jrtp    gaining    scaled    cultures    disease    arising    inflammatory    gender    joint    elusion    molecular    beneficiaries    entrepreneurship    education    oligodendrocyte    neuroinflammation    molecules    cortex    ms    anti    skills    standardised    drugs    talk    stage    biomimetic    miconazole    industry    leadership    immediately    scaffolds    complementary    compulsory    mri    axonal    receive    cell    innovation    model    designed    progressive    discipline    spif    biomaterials    cgmp    organotypic    demyelination    yield    followed    modifying    protocols    spectrophotometry    time    proximal    dispersal    employable    therapy    pms    patient    esrs    degenerative   

Project "PMSMatTrain" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 3˙962˙143 €
 EC max contribution 3˙962˙143 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙373˙421.00
2    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) participant 512˙640.00
3    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 505˙576.00
4    NEOS SURGERY SL ES (DONOSTIA SAN SEBASTIAN) participant 501˙809.00
5    SYDDANSK UNIVERSITET DK (ODENSE M) participant 297˙522.00
6    UNIVERSITE GRENOBLE ALPES FR (GRENOBLE) participant 274˙802.00
7    UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA IT (CHIETI) participant 261˙499.00
8    CONTIPRO AS CZ (DOLNI DOBROUC) participant 234˙871.00
9    UNIVERSITE GRENOBLE ALPES FR (SAINT MARTIN D'HERES) participant 0.00

Map

 Project objective

PMSMatTrain is focusing on gaining a comprehensive understanding of the progressive (late degenerative phase) of multiple sclerosis (PMS) from basics to translation, fully supported by 8 beneficiaries (6 research institutions, 2 SMEs). Recruited ESRs will receive compulsory discipline-specific, generic and complementary transferable skills training. PMSMatTrain’s Joint Research Education and Training programme (JRTP) will provide early stage researchers with high quality research and transferable skills training in intellectual property, leadership skills, innovation, regulatory affairs, entrepreneurship, gender policy, and medical device evaluation, which will ensure that they are immediately employable in industry. The consortium will develop a multi-modal hyaluronan-based medical device designed to release small molecular weight anti-inflammatory molecules (APRIL and sPIF) followed by remyelination and neuroprotective drugs (ibudilast and miconazole). PMSMatTrain will for the first time utilise these functionalised multi-modal biomimetic hyaluronan scaffolds as a tool to investigate cross-talk between signals arising due to chronic neuroinflammation and those leading to demyelination and axonal loss, while identifying molecular mechanisms that facilitate remyelination and neuroprotection in PMS. This approach could yield the first cortex-proximal and directed biomaterials-based disease-modifying therapy for PMS. These scaffolds will be tested in state of the art MS patient induced stem cell-derived oligodendrocyte cultures and organotypic cultures to investigate MS pathophysiology. In vivo responses will be characterised using field-leading MRI and mass spectrophotometry protocols. PMSMatTrain will also generate a clinically-relevant in silico model of drug elusion and dispersal within the CNS. Our industry partners will develop the end-device by providing standardised manufacturing protocols for scaled-up production and commercialisation of the cGMP product.

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The information about "PMSMATTRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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