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PMSMatTrain SIGNED

Novel Biomaterial-based Device for the Treatment of Progressive MS- - An Integrated Pan- European Approach

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EC-Contrib. €

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Partnership

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 PMSMatTrain project word cloud

Explore the words cloud of the PMSMatTrain project. It provides you a very rough idea of what is the project "PMSMatTrain" about.

gender    ibudilast    evaluation    hyaluronan    property    pathophysiology    time    immediately    yield    arising    translation    functionalised    mass    small    stage    transferable    clinically    silico    intellectual    degenerative    stem    oligodendrocyte    remyelination    jrtp    april    elusion    leadership    smes    tested    utilise    therapy    cross    first    scaffolds    mri    chronic    cell    neuroinflammation    modifying    spif    neuroprotective    disease    policy    proximal    directed    recruited    pms    miconazole    education    demyelination    compulsory    esrs    signals    discipline    spectrophotometry    drugs    basics    affairs    complementary    molecules    axonal    employable    beneficiaries    medical    cns    pmsmattrain    weight    inflammatory    modal    talk    vivo    biomimetic    anti    organotypic    patient    sclerosis    progressive    generate    scaled    cultures    entrepreneurship    regulatory    tool    dispersal    manufacturing    device    gaining    protocols    industry    drug    multiple    quality    commercialisation    molecular    skills    characterised    receive    neuroprotection    ms    release    joint    followed    mechanisms    designed    biomaterials    model    standardised    cgmp    cortex    training    innovation   

Project "PMSMatTrain" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 3˙962˙143 €
 EC max contribution 3˙962˙143 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2018
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙373˙421.00
2    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) participant 512˙640.00
3    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 505˙576.00
4    NEOS SURGERY SL ES (DONOSTIA SAN SEBASTIAN) participant 501˙809.00
5    SYDDANSK UNIVERSITET DK (ODENSE M) participant 297˙522.00
6    UNIVERSITE GRENOBLE ALPES FR (GRENOBLE) participant 274˙802.00
7    UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA IT (CHIETI) participant 261˙499.00
8    CONTIPRO AS CZ (DOLNI DOBROUC) participant 234˙871.00
9    UNIVERSITE GRENOBLE ALPES FR (SAINT MARTIN D'HERES) participant 0.00

Map

 Project objective

PMSMatTrain is focusing on gaining a comprehensive understanding of the progressive (late degenerative phase) of multiple sclerosis (PMS) from basics to translation, fully supported by 8 beneficiaries (6 research institutions, 2 SMEs). Recruited ESRs will receive compulsory discipline-specific, generic and complementary transferable skills training. PMSMatTrain’s Joint Research Education and Training programme (JRTP) will provide early stage researchers with high quality research and transferable skills training in intellectual property, leadership skills, innovation, regulatory affairs, entrepreneurship, gender policy, and medical device evaluation, which will ensure that they are immediately employable in industry. The consortium will develop a multi-modal hyaluronan-based medical device designed to release small molecular weight anti-inflammatory molecules (APRIL and sPIF) followed by remyelination and neuroprotective drugs (ibudilast and miconazole). PMSMatTrain will for the first time utilise these functionalised multi-modal biomimetic hyaluronan scaffolds as a tool to investigate cross-talk between signals arising due to chronic neuroinflammation and those leading to demyelination and axonal loss, while identifying molecular mechanisms that facilitate remyelination and neuroprotection in PMS. This approach could yield the first cortex-proximal and directed biomaterials-based disease-modifying therapy for PMS. These scaffolds will be tested in state of the art MS patient induced stem cell-derived oligodendrocyte cultures and organotypic cultures to investigate MS pathophysiology. In vivo responses will be characterised using field-leading MRI and mass spectrophotometry protocols. PMSMatTrain will also generate a clinically-relevant in silico model of drug elusion and dispersal within the CNS. Our industry partners will develop the end-device by providing standardised manufacturing protocols for scaled-up production and commercialisation of the cGMP product.

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The information about "PMSMATTRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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