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SYNTISU SIGNED

Remotely-controlled functional synthetic tissues

Total Cost €

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EC-Contrib. €

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Partnership

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 SYNTISU project word cloud

Explore the words cloud of the SYNTISU project. It provides you a very rough idea of what is the project "SYNTISU" about.

individual    peptides    tissues    printers    formed    protein    synthesis    membrane    medicine    cooperate    printed    therapeutic    assembled    fidelity    functionally    picoliter    electrical    proteins    patterned    transform    patterning    discoveries    separated    investor    energy    synthetic    modulate    lipid    functional    generation    ultimately    mm    full    exceed    safe    generate    transmit    extend    bilayers    faithful    functionalized    stability    laboratory    active    therapeutics    communication    neurons    commercialized    expression    point    shape    external    hierarchical    remotely    atp    unexplored    grant    adventurous    illustrative    erc    networks    magnetism    strictly    structures    internal    light    heat    strength    mimic    resolution    outputs    reversibly    implants    nature    initial    justifies    3d    materials    droplets    biological    showed    replicate    droplet    emergent    muscle    excellent    explore    signals    superior    cm    components    surgical    molecules    release    subject    cells   

Project "SYNTISU" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙428˙065 €
 EC max contribution 2˙428˙065 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙428˙065.00

Map

 Project objective

We will make synthetic tissues for applications in medicine. In the short-term, synthetic tissues will be used to deliver therapeutics; ultimately, synthetic tissues will be used as components of surgical implants. The synthetic tissues will be formed from patterned 3D-printed picoliter droplet networks. They will be functionally active and subject to external control. They will be safe, because they cannot replicate. Key aspects of synthetic tissues, which were introduced by our laboratory, remain unexplored. At this point, our initial work justifies an adventurous full research program. The capabilities of biological tissues greatly exceed those of individual cells, because the cells in them cooperate to produce emergent properties. Our approach considers, but does not strictly mimic nature. 3D printers make patterned networks of picoliter droplets, separated from each other by individual lipid bilayers, which can be functionalized with membrane proteins to allow internal and external communication. In early work, we showed that droplet networks can change shape and transmit electrical signals. Now, we will greatly extend the properties of these materials. We will produce synthetic tissues with excellent fidelity, at high resolution, with faithful patterning and of superior strength and stability. Hierarchical cm-scale structures will be assembled from mm-scale networks. We will make functional tissues able to change shape rapidly and reversibly, take up, transform and release molecules, and generate and use energy. Functional synthetic tissues will be controlled remotely with light, heat, and magnetism. Outputs will include ATP generation and protein expression. Finally, we will explore two illustrative applications of synthetic tissues: the controlled synthesis and release of therapeutic peptides, and the ability to modulate the activities of neurons and muscle cells. Discoveries derived from this ERC grant will be commercialized with investor funding.

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The information about "SYNTISU" are provided by the European Opendata Portal: CORDIS opendata.

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