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SYNTISU SIGNED

Remotely-controlled functional synthetic tissues

Total Cost €

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EC-Contrib. €

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Partnership

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 SYNTISU project word cloud

Explore the words cloud of the SYNTISU project. It provides you a very rough idea of what is the project "SYNTISU" about.

emergent    generate    fidelity    internal    exceed    heat    structures    droplets    discoveries    shape    electrical    individual    reversibly    outputs    networks    excellent    showed    hierarchical    surgical    initial    commercialized    remotely    external    patterning    printed    neurons    faithful    magnetism    therapeutic    subject    adventurous    unexplored    safe    release    3d    signals    grant    picoliter    laboratory    illustrative    point    functional    lipid    muscle    components    transmit    tissues    functionally    strictly    extend    communication    cooperate    explore    materials    separated    atp    energy    mm    full    modulate    therapeutics    molecules    protein    biological    bilayers    patterned    generation    synthesis    droplet    membrane    investor    ultimately    peptides    printers    replicate    nature    superior    functionalized    active    light    strength    expression    medicine    resolution    stability    transform    cm    cells    formed    mimic    justifies    proteins    implants    assembled    synthetic    erc   

Project "SYNTISU" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙428˙065 €
 EC max contribution 2˙428˙065 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙428˙065.00

Map

 Project objective

We will make synthetic tissues for applications in medicine. In the short-term, synthetic tissues will be used to deliver therapeutics; ultimately, synthetic tissues will be used as components of surgical implants. The synthetic tissues will be formed from patterned 3D-printed picoliter droplet networks. They will be functionally active and subject to external control. They will be safe, because they cannot replicate. Key aspects of synthetic tissues, which were introduced by our laboratory, remain unexplored. At this point, our initial work justifies an adventurous full research program. The capabilities of biological tissues greatly exceed those of individual cells, because the cells in them cooperate to produce emergent properties. Our approach considers, but does not strictly mimic nature. 3D printers make patterned networks of picoliter droplets, separated from each other by individual lipid bilayers, which can be functionalized with membrane proteins to allow internal and external communication. In early work, we showed that droplet networks can change shape and transmit electrical signals. Now, we will greatly extend the properties of these materials. We will produce synthetic tissues with excellent fidelity, at high resolution, with faithful patterning and of superior strength and stability. Hierarchical cm-scale structures will be assembled from mm-scale networks. We will make functional tissues able to change shape rapidly and reversibly, take up, transform and release molecules, and generate and use energy. Functional synthetic tissues will be controlled remotely with light, heat, and magnetism. Outputs will include ATP generation and protein expression. Finally, we will explore two illustrative applications of synthetic tissues: the controlled synthesis and release of therapeutic peptides, and the ability to modulate the activities of neurons and muscle cells. Discoveries derived from this ERC grant will be commercialized with investor funding.

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