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SYNTISU SIGNED

Remotely-controlled functional synthetic tissues

Total Cost €

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EC-Contrib. €

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Partnership

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 SYNTISU project word cloud

Explore the words cloud of the SYNTISU project. It provides you a very rough idea of what is the project "SYNTISU" about.

components    faithful    mm    safe    therapeutic    cells    explore    generation    fidelity    hierarchical    synthesis    commercialized    networks    implants    structures    subject    magnetism    3d    erc    bilayers    individual    proteins    internal    membrane    point    outputs    patterned    lipid    molecules    synthetic    medicine    formed    active    unexplored    stability    materials    external    protein    muscle    signals    laboratory    release    functional    reversibly    initial    heat    exceed    shape    showed    full    remotely    transform    mimic    droplet    modulate    strength    justifies    transmit    assembled    peptides    resolution    discoveries    biological    therapeutics    energy    expression    illustrative    tissues    cm    patterning    neurons    picoliter    atp    light    extend    replicate    printed    cooperate    functionally    printers    grant    droplets    surgical    strictly    emergent    separated    nature    ultimately    functionalized    communication    electrical    excellent    investor    generate    superior    adventurous   

Project "SYNTISU" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙428˙065 €
 EC max contribution 2˙428˙065 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙428˙065.00

Map

 Project objective

We will make synthetic tissues for applications in medicine. In the short-term, synthetic tissues will be used to deliver therapeutics; ultimately, synthetic tissues will be used as components of surgical implants. The synthetic tissues will be formed from patterned 3D-printed picoliter droplet networks. They will be functionally active and subject to external control. They will be safe, because they cannot replicate. Key aspects of synthetic tissues, which were introduced by our laboratory, remain unexplored. At this point, our initial work justifies an adventurous full research program. The capabilities of biological tissues greatly exceed those of individual cells, because the cells in them cooperate to produce emergent properties. Our approach considers, but does not strictly mimic nature. 3D printers make patterned networks of picoliter droplets, separated from each other by individual lipid bilayers, which can be functionalized with membrane proteins to allow internal and external communication. In early work, we showed that droplet networks can change shape and transmit electrical signals. Now, we will greatly extend the properties of these materials. We will produce synthetic tissues with excellent fidelity, at high resolution, with faithful patterning and of superior strength and stability. Hierarchical cm-scale structures will be assembled from mm-scale networks. We will make functional tissues able to change shape rapidly and reversibly, take up, transform and release molecules, and generate and use energy. Functional synthetic tissues will be controlled remotely with light, heat, and magnetism. Outputs will include ATP generation and protein expression. Finally, we will explore two illustrative applications of synthetic tissues: the controlled synthesis and release of therapeutic peptides, and the ability to modulate the activities of neurons and muscle cells. Discoveries derived from this ERC grant will be commercialized with investor funding.

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