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MICROX SIGNED

Microscopy of living cancer cells at physiological oxygen levels: the MICROX platform

Total Cost €

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EC-Contrib. €

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Partnership

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 MICROX project word cloud

Explore the words cloud of the MICROX project. It provides you a very rough idea of what is the project "MICROX" about.

oxygen    exquisite    evaluation    enclose    sensitivity    maintained    bioactive    olga    atmospheric    solid    hi    group    modern    signalling    combination    assays    monitoring    generally    spatial    facilities    close    tight    dramatically    fluorescent    preparation    mazina    lt    outperform    never    optical    hypoxic    validated    function    functional    dynamic    prof    pharmacologist    biochemist    tested    regimens    dr    world    oxygenation    good    incubators    private    cancer    microscopy    panel    cell    probe    compounds    medical    drug    maintaining    resolution    living    drugs    bodies    microscopes    manufacturers    kees    luminescence    urgent       treatments    content    evident    innovative    societies    events    platform    hypoxia    reader       o2    plate    complement    screening    trivial    candidates    temporal    adjustable    optimized    tumours    jalink    biosensors    microx    conventional    team    cells    academic    remarkably    21    fluorescence    efficacy    discovering    levels    treatment   

Project "MICROX" data sheet

The following table provides information about the project.

Coordinator
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS 

Organization address
address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX
website: www.nki.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 281˙358 €
 EC max contribution 281˙358 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-09-15   to  2022-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) coordinator 281˙358.00

Map

 Project objective

Functional evaluation of bioactive compounds using cell-based assays is key in discovering new and improved drugs to address our societies growing medical needs. In a large number of academic and private R&D facilities around the world, hi-content microscopy screening is used to complement and often outperform the conventional luminescence and fluorescence plate-reader assays. The combination of fluorescent-probe technology, modern optical microscopes and innovative functional assays allows monitoring highly dynamic events in living cells with exquisite temporal and spatial resolution. Remarkably, drug candidates and treatment regimens are commonly tested on living cells maintained at atmospheric oxygenation levels (i.e., at 21% O2) while in reality, cells in our bodies never experience such high oxygen levels. Rather, most cells experience 2-5% of O2 and cancer cells in solid tumours are generally hypoxic, i.e., they function at < 1% of O2. It has become evident that oxygenation of the preparation dramatically affects efficacy of our drugs, in particular of cancer treatments. Thus, there is an urgent need to establish functional microscopy assays for (cancer)drug efficacy at hypoxic conditions. However, it is not trivial to enclose the necessary high-end microscopes in O2-tight incubators while maintaining good access to the cells. In this project, experienced biochemist and pharmacologist dr. Olga Mazina aims to team up with the advanced microscopy group of prof. Kees Jalink to establish an innovative MICROX microscopy platform with fully adjustable atmospheric conditions, along with a panel of biosensors optimized for use at hypoxia. MICROX will be developed in close collaboration with leading European manufacturers and validated in studies addressing cancer cell signalling and sensitivity to cancer drugs at various O2 levels.

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The information about "MICROX" are provided by the European Opendata Portal: CORDIS opendata.

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