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MICROX SIGNED

Microscopy of living cancer cells at physiological oxygen levels: the MICROX platform

Total Cost €

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EC-Contrib. €

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Partnership

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 MICROX project word cloud

Explore the words cloud of the MICROX project. It provides you a very rough idea of what is the project "MICROX" about.

dramatically    hypoxia    tested    medical    compounds    team    close    drug    prof    treatment    evaluation    temporal    incubators    probe    drugs    plate    efficacy    adjustable    exquisite    hi    microx       combination    academic    hypoxic    generally    oxygen    societies    living    tight    content    private    biochemist    function    enclose    discovering    optimized    biosensors    functional    facilities    microscopes    tumours    cells    lt    validated    signalling    maintaining    world    conventional    fluorescent    oxygenation    jalink    evident    outperform    preparation    luminescence    mazina    microscopy    monitoring    sensitivity    atmospheric    regimens    spatial    dr    kees    o2    maintained    cancer    assays    manufacturers    candidates    reader    optical    treatments    dynamic    bioactive    never    21    good    urgent    olga       fluorescence    modern    platform    complement    resolution    trivial    pharmacologist    screening    levels    events    innovative    solid    bodies    panel    cell    remarkably    group   

Project "MICROX" data sheet

The following table provides information about the project.

Coordinator
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS 

Organization address
address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX
website: www.nki.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 281˙358 €
 EC max contribution 281˙358 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-09-15   to  2022-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) coordinator 281˙358.00

Map

 Project objective

Functional evaluation of bioactive compounds using cell-based assays is key in discovering new and improved drugs to address our societies growing medical needs. In a large number of academic and private R&D facilities around the world, hi-content microscopy screening is used to complement and often outperform the conventional luminescence and fluorescence plate-reader assays. The combination of fluorescent-probe technology, modern optical microscopes and innovative functional assays allows monitoring highly dynamic events in living cells with exquisite temporal and spatial resolution. Remarkably, drug candidates and treatment regimens are commonly tested on living cells maintained at atmospheric oxygenation levels (i.e., at 21% O2) while in reality, cells in our bodies never experience such high oxygen levels. Rather, most cells experience 2-5% of O2 and cancer cells in solid tumours are generally hypoxic, i.e., they function at < 1% of O2. It has become evident that oxygenation of the preparation dramatically affects efficacy of our drugs, in particular of cancer treatments. Thus, there is an urgent need to establish functional microscopy assays for (cancer)drug efficacy at hypoxic conditions. However, it is not trivial to enclose the necessary high-end microscopes in O2-tight incubators while maintaining good access to the cells. In this project, experienced biochemist and pharmacologist dr. Olga Mazina aims to team up with the advanced microscopy group of prof. Kees Jalink to establish an innovative MICROX microscopy platform with fully adjustable atmospheric conditions, along with a panel of biosensors optimized for use at hypoxia. MICROX will be developed in close collaboration with leading European manufacturers and validated in studies addressing cancer cell signalling and sensitivity to cancer drugs at various O2 levels.

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The information about "MICROX" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-27 23:01:04) correctly updated