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MICROX SIGNED

Microscopy of living cancer cells at physiological oxygen levels: the MICROX platform

Total Cost €

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EC-Contrib. €

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Partnership

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 MICROX project word cloud

Explore the words cloud of the MICROX project. It provides you a very rough idea of what is the project "MICROX" about.

regimens    hi    academic    manufacturers    enclose    compounds       oxygen    platform    jalink    cell    trivial    efficacy    drug    group    complement    function    events    evident    solid    atmospheric    private    facilities    screening    evaluation    cancer    modern    incubators    societies    dynamic    oxygenation    spatial    innovative    close    mazina    signalling    sensitivity    dramatically    bodies    microscopes    validated    cells    optical    fluorescent    never    exquisite    levels    temporal    assays    content    biochemist    world    optimized    prof    probe    good    tested    generally    lt    medical    microscopy    discovering    hypoxia    urgent    living    candidates    team    treatment    o2    preparation    resolution    21    treatments    tumours    hypoxic    conventional    tight    dr    bioactive    maintaining    adjustable    monitoring    drugs    reader    kees    maintained    fluorescence       plate    biosensors    functional    olga    pharmacologist    combination    luminescence    remarkably    microx    outperform    panel   

Project "MICROX" data sheet

The following table provides information about the project.

Coordinator
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS 

Organization address
address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX
website: www.nki.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 281˙358 €
 EC max contribution 281˙358 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-09-15   to  2022-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) coordinator 281˙358.00

Map

 Project objective

Functional evaluation of bioactive compounds using cell-based assays is key in discovering new and improved drugs to address our societies growing medical needs. In a large number of academic and private R&D facilities around the world, hi-content microscopy screening is used to complement and often outperform the conventional luminescence and fluorescence plate-reader assays. The combination of fluorescent-probe technology, modern optical microscopes and innovative functional assays allows monitoring highly dynamic events in living cells with exquisite temporal and spatial resolution. Remarkably, drug candidates and treatment regimens are commonly tested on living cells maintained at atmospheric oxygenation levels (i.e., at 21% O2) while in reality, cells in our bodies never experience such high oxygen levels. Rather, most cells experience 2-5% of O2 and cancer cells in solid tumours are generally hypoxic, i.e., they function at < 1% of O2. It has become evident that oxygenation of the preparation dramatically affects efficacy of our drugs, in particular of cancer treatments. Thus, there is an urgent need to establish functional microscopy assays for (cancer)drug efficacy at hypoxic conditions. However, it is not trivial to enclose the necessary high-end microscopes in O2-tight incubators while maintaining good access to the cells. In this project, experienced biochemist and pharmacologist dr. Olga Mazina aims to team up with the advanced microscopy group of prof. Kees Jalink to establish an innovative MICROX microscopy platform with fully adjustable atmospheric conditions, along with a panel of biosensors optimized for use at hypoxia. MICROX will be developed in close collaboration with leading European manufacturers and validated in studies addressing cancer cell signalling and sensitivity to cancer drugs at various O2 levels.

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The information about "MICROX" are provided by the European Opendata Portal: CORDIS opendata.

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