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MICROX SIGNED

Microscopy of living cancer cells at physiological oxygen levels: the MICROX platform

Total Cost €

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EC-Contrib. €

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Partnership

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 MICROX project word cloud

Explore the words cloud of the MICROX project. It provides you a very rough idea of what is the project "MICROX" about.

bodies    microx    probe    dramatically    function    monitoring    regimens    dr       drug    evaluation    hi    oxygenation    preparation    manufacturers    jalink    microscopes    biochemist    content    prof    platform    discovering    atmospheric    innovative    world    levels    facilities    cell    dynamic    microscopy    adjustable    living    good    oxygen    outperform    tumours    generally    modern    drugs    evident    resolution    screening    academic    treatment    hypoxia    temporal    treatments    maintaining    fluorescence    optical    bioactive    luminescence    close    medical    fluorescent    sensitivity    tested    pharmacologist    exquisite    kees    remarkably    maintained    solid    olga    cancer    signalling    functional    spatial    candidates    events    reader    urgent    team    hypoxic    never    cells    compounds    societies    group    efficacy    21    lt    complement    tight    plate    incubators       mazina    validated    biosensors    combination    conventional    panel    private    assays    trivial    enclose    o2    optimized   

Project "MICROX" data sheet

The following table provides information about the project.

Coordinator
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS 

Organization address
address: PLESMANLAAN 121
city: AMSTERDAM
postcode: 1066 CX
website: www.nki.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 281˙358 €
 EC max contribution 281˙358 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-09-15   to  2022-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) coordinator 281˙358.00

Map

 Project objective

Functional evaluation of bioactive compounds using cell-based assays is key in discovering new and improved drugs to address our societies growing medical needs. In a large number of academic and private R&D facilities around the world, hi-content microscopy screening is used to complement and often outperform the conventional luminescence and fluorescence plate-reader assays. The combination of fluorescent-probe technology, modern optical microscopes and innovative functional assays allows monitoring highly dynamic events in living cells with exquisite temporal and spatial resolution. Remarkably, drug candidates and treatment regimens are commonly tested on living cells maintained at atmospheric oxygenation levels (i.e., at 21% O2) while in reality, cells in our bodies never experience such high oxygen levels. Rather, most cells experience 2-5% of O2 and cancer cells in solid tumours are generally hypoxic, i.e., they function at < 1% of O2. It has become evident that oxygenation of the preparation dramatically affects efficacy of our drugs, in particular of cancer treatments. Thus, there is an urgent need to establish functional microscopy assays for (cancer)drug efficacy at hypoxic conditions. However, it is not trivial to enclose the necessary high-end microscopes in O2-tight incubators while maintaining good access to the cells. In this project, experienced biochemist and pharmacologist dr. Olga Mazina aims to team up with the advanced microscopy group of prof. Kees Jalink to establish an innovative MICROX microscopy platform with fully adjustable atmospheric conditions, along with a panel of biosensors optimized for use at hypoxia. MICROX will be developed in close collaboration with leading European manufacturers and validated in studies addressing cancer cell signalling and sensitivity to cancer drugs at various O2 levels.

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The information about "MICROX" are provided by the European Opendata Portal: CORDIS opendata.

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