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Optoheart SIGNED

All-optical framework for the correlative imaging of cardiac meso-scale cytoarchitecture and multi-scale electrical conduction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Optoheart project word cloud

Explore the words cloud of the Optoheart project. It provides you a very rough idea of what is the project "Optoheart" about.

muscle    hearts    regions    arrhythmias    sudden    transmembrane    conduction    correlated    simultaneously    patterns    activation    mi    invasive    proof    tissue    abnormal    organs    death    heart    rhythms    channels    stimulation    3d    influences    correlative    context    techniques    architecture    heterogeneity    diseased    treat    mammalian    myocardial    limitations    vasculature    combination    channelrhodopsin    electrical    intact    mortality    quantifying    easily    questions    cytoarchitecture    overlap    optogenetics    concerning    clearing    platform    realise    tool    underlying    cardio    experimentally    innovative    clinically    infarction    individual    microstructural    risk    multiphoton    interfaces    voltage    capability    cardiac    patho    microscopy    scar    custom    time    myocardium    depths    therapies    spectral    healthy    global    gated    versatile    structurally    combines    physiology    platforms    data    imaging    framework    optical    light    employing    altered    ion    restricting    mapped    sheet    stimulate    combining   

Project "Optoheart" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 212˙933.00

Map

 Project objective

Myocardial infarction (MI) is a key risk factor for sudden cardiac death, a leading global cause of mortality. Understanding how altered tissue architecture in MI influences cardiac electrical conduction is crucial to develop therapies which treat abnormal heart rhythms (arrhythmias) clinically. Optical measurement of transmembrane voltage in cardiac muscle is a versatile, non-invasive tool to investigate myocardial conduction. However, the current techniques of wide-field and multiphoton imaging have individual limitations restricting their ability to study key features of conduction in a 3D framework. Furthermore, optogenetics cannot be easily implemented in imaging platforms due to spectral overlap with the activation of light-gated ion channels such as channelrhodopsin. Combining all 3 techniques will provide a platform to study electrical conduction within mammalian myocardium in a 3D context and will be capable of quantifying effects introduced by tissue heterogeneity such as vasculature and scar tissue. The proposed project combines development of novel imaging technology with applied cardio-(patho)-physiology to study cardiac conduction at tissue interfaces in intact hearts with an innovative correlative approach. A new all-optical platform will be developed to simultaneously measure and stimulate cardiac activity, with the capability for real-time stimulation using custom optical patterns. Conduction will be mapped experimentally across structurally distinct regions and depths in healthy and MI hearts. This data will be correlated with underlying cytoarchitecture in the same hearts by employing tissue clearing in combination with novel light-sheet microscopy for imaging of structurally intact whole organs. This work will realise a new platform to study conduction in 3D microstructural context and deliver proof-of-concept data to address key questions concerning electrical behaviour in healthy and diseased hearts.

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The information about "OPTOHEART" are provided by the European Opendata Portal: CORDIS opendata.

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