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NeuroFreezing SIGNED

Biophysical Properties of the Neuronal Cytosol and their Dynamics upon Nutrient Starvation, Aging, and in Neurodegenerative Diseases.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NeuroFreezing project word cloud

Explore the words cloud of the NeuroFreezing project. It provides you a very rough idea of what is the project "NeuroFreezing" about.

aged    inherited    shifting    biophysical    cells    differences    stress    cell    neurodegenerative    regulate    regulated    regulating    rates    aggregation    metabolism    unclear    mammalian    yeast    diffusive    starvation    polyq    sufficient    fundamentally    induce    density    types    hallmark    hd    dynamic    deprived    exhibit    proteins    disease    model    h1    trigger    cytosolic    cytosol    stable    huntington    poorly    intracellular    glucose    strategies    neurons    hypotheses    despite    diseases    techniques    influence    separations    disorders    environmental    transport    aging    paradigm    biophysics    description    potentially    nutrient    decrease    first    combining    protein    material    interactions    neuronal    reveal    h2    ultimately    polyglutamine    alter    critical    biochemistry    discovered    inducing    stresses    expertise    homogeneous    molecular    actively    viscosity    crowding    investigation    neurobiology    therapeutic    volume    mouse   

Project "NeuroFreezing" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 203˙149 €
 EC max contribution 203˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 203˙149.00

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 Project objective

The material properties of the cytosol control the biochemistry of the cell and influence all molecular interactions by regulating rates of intracellular diffusive transport. Despite this critical role, these properties remain poorly understood, and it is unclear to what extent the cytosol is homogeneous, whether there are differences between cell types, and if these properties are stable or dynamic. It has recently been discovered that yeast cells regulate their cytosolic properties in response to stress, namely glucose-starvation and aging. These stresses result in a decrease in cell volume and an increase in cytosolic crowding, inducing widespread phase separations and aggregation of polyglutamine (polyQ)-proteins. This type of polyQ-protein aggregation is the molecular hallmark of neurodegenerative diseases like Huntington's Disease (HD), and is very poorly understood. In this project, I will produce the first description of the biophysical properties of the neuronal cytosol, and I will directly test whether aged or nutrient-deprived neurons, or neurons from an HD mouse model exhibit changes in these properties. I propose that viscosity and density of mammalian cells, and in particular neuronal cells, are dynamic properties that can be actively regulated in response to environmental changes. In particular, I will test two hypotheses: - H1: Nutrient starvation and aging induce changes to the material properties of the neuronal cytosol. - H2: A neuronal stress-response upon starvation or aging is sufficient to trigger aggregation of polyQ-proteins. Combining state-of-the-art techniques and expertise in the fields of neurobiology, metabolism, and biophysics, my investigation of these novel and potentially paradigm shifting hypotheses could fundamentally alter our understanding of the material properties of the neuronal cytosol, and ultimately reveal new therapeutic strategies for the most common inherited neurodegenerative disorders.

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The information about "NEUROFREEZING" are provided by the European Opendata Portal: CORDIS opendata.

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