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EVOMORPHYS SIGNED

Identifying how Evolution exploits physical properties of tissues to generate the complexity and diversity of Life

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EVOMORPHYS project word cloud

Explore the words cloud of the EVOMORPHYS project. It provides you a very rough idea of what is the project "EVOMORPHYS" about.

principles    signalling    artificial    simulations    experiments    question    layered    patterns    models    configurations    events    laboratory    effect    morphogenesis    explore    migration    extensive    cas9    biological    complexity    mutants    numerical    latter    physical    morphological    constitute    explores    squamate    morphologies    fundamental    diversity    multiple    scaleless    drivers    pattern    first    ended    physics    darwinian    systematically    reaction    living    mathematical    colour    crispr    imaging    generates    biology    answering    exploits    evolutionary    claim    genetic    performing    functional    3d    symmetry    modify    silico    forms    diffusion    lizard    polymeric    model    generate    framework    combine    proliferation    newtonian    species    evomorphys    my    mechanics    correspondences    cell    breaking    evolution    geometry    geometries    generating    explored    skin    gels    synthesis    captures    life    interactions    coupling    space    phenotypes    patterning    compute    algorithm    embryonic    alife   

Project "EVOMORPHYS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE GENEVE 

Organization address
address: RUE DU GENERAL DUFOUR 24
city: GENEVE
postcode: 1211
website: www.unige.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙499˙070 €
 EC max contribution 2˙499˙070 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE CH (GENEVE) coordinator 2˙499˙070.00

Map

 Project objective

My project focuses on answering one fundamental question: what are the drivers of Life’s morphological complexity and diversity? I claim that this question can only be addressed by a Newtonian-Darwinian synthesis that considers how Evolution exploits the physical properties of living matter. I will investigate how the evolutionary process explores the phase space of possible interactions between physical (mechanics, reaction-diffusion) and biological (cell signalling, proliferation, migration) processes and generates configurations that compute functional phenotypes. In particular, I will combine experiments in biology and physics, as well as mathematical models and Artificial-Life (ALife) numerical simulations. The latter will be based on physics’ first principles, symmetry-breaking processes and a genetic algorithm. First, I will investigate how geometry affects signalling by (i) imaging the embryonic development of colour patterns and skin geometries of multiple squamate species with various scale-to-colour pattern correspondences, (ii) generating CRISPR/Cas9 scaleless mutants in two lizard species to study the effect of skin 3D geometry on colour patterning, and (iii) performing ALife experiments to explore how the evolutionary process can modify signalling events and exploit geometry to generate new patterns. Second, I will analyse how growth can affect geometry by (i) performing in-silico experiments where coupling between growth and morphogenesis is systematically explored and (ii) evaluating how much the in-silico model captures morphologies generated with physics laboratory experiments using 3D layered polymeric gels. Third, I will build a Newtonian-Darwinian framework by coupling geometry, signalling, growth and mechanics in extensive open-ended ALife experiments. The results of the EVOMORPHYS project will constitute a novel framework for understanding how Evolution exploits physics to generate the morphological diversity and complexity of Life forms.

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The information about "EVOMORPHYS" are provided by the European Opendata Portal: CORDIS opendata.

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