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CANSAS SIGNED

Clustering functional connectivity alterations in Autism Spectrum Disorders

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CANSAS project word cloud

Explore the words cloud of the CANSAS project. It provides you a very rough idea of what is the project "CANSAS" about.

autism    patient    fmri    revealed    mapping    therapeutic    rsfmri    contrasting    ontologies    underpinnings    connectivity    gene    statistical    socio    leverages    precise    guide    fingerprints    ground    alterations    developmental    decomposition    patients    network    first    treatment    functional    types    deficits    validated    cohorts    resting    heterogeneity    comprising    combine    asd    amenable    genetic    explore    profiling    clinically    unclear    divergences    employed    fostered    clusters    spectrum    identification    cognitive    deconstruction    probe    disorders    biologically    dysfunctional    mouse    cluster    inconsistent    patterns    significance    translationally    etiologically    clinical    collection    biological    clustering    rare    critical    heterogeneous    recapitulating    advent    synchronization    neurobiological    investigations    brain    sub    homogeneity    prediction    origin    neural    heritable    mutations    deconstruct    stratification    truth    datasets    connectional    homogeneous    human   

Project "CANSAS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 269˙002 €
 EC max contribution 269˙002 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 269˙002.00
2    CHILD MIND INSTITUTE, INC US (NEW YORK) partner 0.00

Map

 Project objective

Autism spectrum disorders (ASD) are among the most heritable developmental disorders, associated with a large number of rare genetic alterations. A critical goal of current ASD research is to deconstruct its heterogeneity into clinically homogeneous sub-set of patients, characterized by distinct neurobiological or functional deficits, amenable to precise therapeutic targeting. Fostered by the advent of resting-state fMRI (rsfMRI), human brain mapping has revealed highly heterogeneous patterns of neural synchronization (i.e. “functional connectivity”) in ASD, with evidence of inconsistent, often contrasting, patterns of over- and under-connectivity across patient cohorts. However, the origin and significance of these highly heterogeneous findings remain unclear: does genetic heterogeneity account for the observed network divergences? And can we use functional connectivity fingerprints to cluster ASD into clinically relevant sub-types? The present project leverages translationally-relevant mouse brain rsfMRI measurements to propose a first-of-its-kind decomposition of human ASD rsfMRI datasets into homogeneous sub-types, recapitulating biologically-validated “ground truth” network features identified in the mouse. To this aim, I will use a set of etiologically-relevant rsfMRI fingerprints identified in a unique mouse datasets comprising 20 ASD-associated mutations to guide clustering of a large collection of human rsfMRI datasets. Socio-cognitive profiling will be employed to probe the clinical significance and homogeneity of the identified clusters. I will next combine advanced statistical modelling and gene ontologies to explore the biological underpinnings of each identified connectivity sub-type. These investigations will lead to a novel, etiologically-relevant deconstruction of the connectional and clinical heterogeneity of ASD that may improve patient stratification, guide the identification of dysfunctional pathways and help prediction of treatment response.

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The information about "CANSAS" are provided by the European Opendata Portal: CORDIS opendata.

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