Opendata, web and dolomites

CANSAS SIGNED

Clustering functional connectivity alterations in Autism Spectrum Disorders

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CANSAS project word cloud

Explore the words cloud of the CANSAS project. It provides you a very rough idea of what is the project "CANSAS" about.

heritable    leverages    first    ground    fostered    profiling    sub    prediction    amenable    translationally    patient    divergences    datasets    identification    spectrum    autism    biological    clusters    guide    dysfunctional    synchronization    investigations    precise    stratification    types    human    combine    cluster    socio    cohorts    cognitive    critical    truth    homogeneous    homogeneity    biologically    clinical    unclear    contrasting    collection    patients    validated    patterns    inconsistent    disorders    connectivity    deconstruct    explore    connectional    neural    ontologies    employed    network    functional    mutations    therapeutic    rare    deconstruction    etiologically    clustering    fingerprints    heterogeneous    resting    treatment    origin    recapitulating    developmental    heterogeneity    significance    comprising    genetic    mapping    fmri    advent    underpinnings    alterations    decomposition    clinically    gene    deficits    rsfmri    neurobiological    revealed    probe    statistical    mouse    brain    asd   

Project "CANSAS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 269˙002 €
 EC max contribution 269˙002 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 269˙002.00
2    CHILD MIND INSTITUTE, INC US (NEW YORK) partner 0.00

Map

 Project objective

Autism spectrum disorders (ASD) are among the most heritable developmental disorders, associated with a large number of rare genetic alterations. A critical goal of current ASD research is to deconstruct its heterogeneity into clinically homogeneous sub-set of patients, characterized by distinct neurobiological or functional deficits, amenable to precise therapeutic targeting. Fostered by the advent of resting-state fMRI (rsfMRI), human brain mapping has revealed highly heterogeneous patterns of neural synchronization (i.e. “functional connectivity”) in ASD, with evidence of inconsistent, often contrasting, patterns of over- and under-connectivity across patient cohorts. However, the origin and significance of these highly heterogeneous findings remain unclear: does genetic heterogeneity account for the observed network divergences? And can we use functional connectivity fingerprints to cluster ASD into clinically relevant sub-types? The present project leverages translationally-relevant mouse brain rsfMRI measurements to propose a first-of-its-kind decomposition of human ASD rsfMRI datasets into homogeneous sub-types, recapitulating biologically-validated “ground truth” network features identified in the mouse. To this aim, I will use a set of etiologically-relevant rsfMRI fingerprints identified in a unique mouse datasets comprising 20 ASD-associated mutations to guide clustering of a large collection of human rsfMRI datasets. Socio-cognitive profiling will be employed to probe the clinical significance and homogeneity of the identified clusters. I will next combine advanced statistical modelling and gene ontologies to explore the biological underpinnings of each identified connectivity sub-type. These investigations will lead to a novel, etiologically-relevant deconstruction of the connectional and clinical heterogeneity of ASD that may improve patient stratification, guide the identification of dysfunctional pathways and help prediction of treatment response.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CANSAS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CANSAS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Catenin-Condensation (2020)

The effect of β-catenin condensation on the Wnt-pathway

Read More  

RhinalMultiSense (2020)

Circuits for multisensory integration in the perirhinal cortex

Read More  

GLORIOUS (2019)

Digital Poetry in Today’s Russia: Canonisation and Translation

Read More