Opendata, web and dolomites
NGI SIGNED
Next Generation Imaging
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0NGI project word cloud
Explore the words cloud of the NGI project. It provides you a very rough idea of what is the project "NGI" about.
handle
robustness
transcriptional
led
reduce
single
spatial
organisms
epigenetics
fly
advantages
retrieve
independent
transcription
simultaneous
ubiquitous
sequencing
science
cancer
structure
critically
combinatorial
context
protein
genetics
data
tool
fundamental
ngi
genomics
cells
drastically
hundreds
thousands
improvements
friendliness
diseases
cell
generation
acid
diabetes
rna
robot
neuroscience
deep
unable
considerably
labeling
regulation
species
liquid
discoveries
limitation
detection
dna
3d
learning
chromosome
revolutionary
acids
implementing
pipelines
parallelized
next
neurological
scheme
intact
ngs
nucleic
technologies
hi
imaging
acquisition
tens
tissues
relies
organization
resolution
handling
detected
throughput
tissue
adapt
time
improvement
validating
academic
clinic
Project "NGI" data sheet
The following table provides information about the project.
| Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-09-01 to 2021-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 150˙000.00 |
Map
Project objective
Next generation sequencing has led to revolutionary discoveries in the fields of genetics, genomics, epigenetics and transcriptional regulation. The main limitation of this technology relies on the loss of spatial information: NGS is unable to retrieve the organization of nucleic acids (DNA/RNA) in the cell or within the more complex structure of the tissue. We have recently developed a novel imaging-based technology, Hi-M, that enables the simultaneous detection of tens of DNA and RNA species in single cells within the context of intact tissues. In NGI, we propose to make major improvements to drastically reduce data acquisition and analysis time, considerably increase throughput and number of independent nucleic-acid species detected, and improve the robustness of acquisition and the user-friendliness of analysis. These objectives will be achieved by implementing, testing and validating a novel combinatorial labeling scheme, parallelized acquisition, improvement of the liquid-handling robot to handle hundreds of independent species, and on-the-fly analysis using deep learning technologies to provide more robust data analysis pipelines and adapt acquisition parameters in real time. These improvements will enable simultaneous detection of thousands of species (DNA, RNA or protein) in single-cells with spatial resolution within the context of complex organisms and tissues. Because of these important advantages over existing technologies, NGI will be key to future discoveries in the fields of genetics, genomics and transcription. Critically, NGI will also have a large impact in other fundamental and applied fields where knowledge of spatial organization of transcription and 3D chromosome organization at the single-cell level are relevant: neuroscience and neurological diseases, diabetes, cancer, etc. Thus, NGI has the potential to become an ubiquitous tool not only in academic science but also at the clinic.
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The information about "NGI" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-07-27 2:14:03) correctly updated