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Retinoic AC-DC SIGNED

Role of Retinoic Acid signaling in cDC1 and cDC2 on intestinal immune homeostasis and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Retinoic AC-DC project word cloud

Explore the words cloud of the Retinoic AC-DC project. It provides you a very rough idea of what is the project "Retinoic AC-DC" about.

professional    dendritic    health    critical    environmental    cdc    technologies    vit    effect    deficiency    for    homing    communication    effectors    world    undeniable    innovative    protocol    dr    organization    international    conventional    immune    candidate    phd    vad    usually    vitamin    laboratory    supplementation    absorbed    phenotypic    action    enabled    intestine    children    pathologic    intestinal    pregnant    mostly    acquire    individual    small    retinoic    cells    acid    techniques    highlighted    skills    transcriptomic    polarization    profile    mothers    central    acquired    secondary    reinforcing    national    triggered    competences    host    cutting    quality    enhanced    participation    infrastructure    infectious    writing    thinking    solid    immunity    levels    complementary    diseases    efficient    unknown    homeostatic    investigation    researcher    metabolites    independent    impacting    collaborations    manipulating    agace    edge    avoiding    signals    network    consequently    ra   

Project "Retinoic AC-DC" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 191˙852.00

Map

 Project objective

For the past years, it has become undeniable that environmental signals have a great impact on the intestinal immune system. Among them, the Vitamin A (Vit A) has a central role in intestinal immunity. Consequently, the Vit A deficiency (VAD) is associated with an increase of infectious diseases and the supplementation of Vit A to pregnant mothers and children is a protocol defined by the World Health Organization. The vit A is mostly absorbed in the small intestine and derived into Retinoic Acid (RA), especially by conventional dendritic cells (cDC). Studies on the impact of RA on intestinal immunity, including in the host laboratory, have highlighted a major impact of RA produced by cDC on the homing and the polarization of effectors cells, although the effect of the RA on specific cDC subsets remains unknown. The understanding of this effect is an essential step for manipulating the system while avoiding secondary effects, usually triggered by impacting such central metabolites as RA. We propose to define this specific action of the RA on cDC using cutting edge technologies and state of art techniques both developed in the laboratory and brought by the candidate. These techniques will allow the investigation of the RA effect on specific intestinal cDC subsets at transcriptomic and phenotypic levels under homeostatic and pathologic states. The host laboratory will develop the professional skills of the candidate by reinforcing his individual competences, including laboratory techniques, writing, critical and innovative thinking, and communication abilities. Those will be further enhanced by the participation to many national and international collaborations enabled by Dr. Agace’s strong network. The high-quality infrastructure provided to the candidate and his complementary profile and techniques, acquired during his PhD, will ensure a solid project development and allow him to acquire all the abilities needed to become an efficient independent researcher.

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