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Retinoic AC-DC SIGNED

Role of Retinoic Acid signaling in cDC1 and cDC2 on intestinal immune homeostasis and disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Retinoic AC-DC project word cloud

Explore the words cloud of the Retinoic AC-DC project. It provides you a very rough idea of what is the project "Retinoic AC-DC" about.

cutting    profile    homeostatic    network    reinforcing    skills    solid    complementary    national    pathologic    cdc    world    polarization    vad    innovative    mothers    phd    central    immune    participation    absorbed    consequently    health    mostly    candidate    undeniable    protocol    dendritic    acid    unknown    signals    intestine    usually    transcriptomic    phenotypic    competences    action    individual    laboratory    investigation    for    homing    secondary    vit    intestinal    acquired    effectors    highlighted    communication    organization    ra    levels    acquire    manipulating    quality    deficiency    vitamin    triggered    enabled    environmental    agace    retinoic    infrastructure    conventional    writing    cells    international    edge    small    technologies    diseases    avoiding    impacting    critical    pregnant    effect    researcher    metabolites    efficient    enhanced    children    thinking    professional    supplementation    immunity    dr    techniques    infectious    host    independent    collaborations   

Project "Retinoic AC-DC" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 191˙852.00

Map

 Project objective

For the past years, it has become undeniable that environmental signals have a great impact on the intestinal immune system. Among them, the Vitamin A (Vit A) has a central role in intestinal immunity. Consequently, the Vit A deficiency (VAD) is associated with an increase of infectious diseases and the supplementation of Vit A to pregnant mothers and children is a protocol defined by the World Health Organization. The vit A is mostly absorbed in the small intestine and derived into Retinoic Acid (RA), especially by conventional dendritic cells (cDC). Studies on the impact of RA on intestinal immunity, including in the host laboratory, have highlighted a major impact of RA produced by cDC on the homing and the polarization of effectors cells, although the effect of the RA on specific cDC subsets remains unknown. The understanding of this effect is an essential step for manipulating the system while avoiding secondary effects, usually triggered by impacting such central metabolites as RA. We propose to define this specific action of the RA on cDC using cutting edge technologies and state of art techniques both developed in the laboratory and brought by the candidate. These techniques will allow the investigation of the RA effect on specific intestinal cDC subsets at transcriptomic and phenotypic levels under homeostatic and pathologic states. The host laboratory will develop the professional skills of the candidate by reinforcing his individual competences, including laboratory techniques, writing, critical and innovative thinking, and communication abilities. Those will be further enhanced by the participation to many national and international collaborations enabled by Dr. Agace’s strong network. The high-quality infrastructure provided to the candidate and his complementary profile and techniques, acquired during his PhD, will ensure a solid project development and allow him to acquire all the abilities needed to become an efficient independent researcher.

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