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Role of Retinoic Acid signaling in cDC1 and cDC2 on intestinal immune homeostasis and disease

Total Cost €


EC-Contrib. €






 Retinoic AC-DC project word cloud

Explore the words cloud of the Retinoic AC-DC project. It provides you a very rough idea of what is the project "Retinoic AC-DC" about.

mostly    action    effect    laboratory    homeostatic    independent    undeniable    world    consequently    technologies    reinforcing    homing    solid    avoiding    efficient    vit    transcriptomic    enabled    infrastructure    signals    writing    innovative    environmental    for    absorbed    usually    quality    dendritic    vitamin    techniques    collaborations    mothers    manipulating    metabolites    host    impacting    central    immunity    researcher    children    participation    national    thinking    ra    enhanced    intestinal    investigation    cells    small    supplementation    immune    highlighted    acid    edge    conventional    network    intestine    diseases    retinoic    individual    acquire    complementary    professional    acquired    organization    cdc    skills    pathologic    competences    levels    profile    triggered    vad    protocol    cutting    international    effectors    critical    agace    pregnant    unknown    dr    secondary    phd    health    deficiency    phenotypic    infectious    polarization    candidate    communication   

Project "Retinoic AC-DC" data sheet

The following table provides information about the project.


Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 191˙852.00


 Project objective

For the past years, it has become undeniable that environmental signals have a great impact on the intestinal immune system. Among them, the Vitamin A (Vit A) has a central role in intestinal immunity. Consequently, the Vit A deficiency (VAD) is associated with an increase of infectious diseases and the supplementation of Vit A to pregnant mothers and children is a protocol defined by the World Health Organization. The vit A is mostly absorbed in the small intestine and derived into Retinoic Acid (RA), especially by conventional dendritic cells (cDC). Studies on the impact of RA on intestinal immunity, including in the host laboratory, have highlighted a major impact of RA produced by cDC on the homing and the polarization of effectors cells, although the effect of the RA on specific cDC subsets remains unknown. The understanding of this effect is an essential step for manipulating the system while avoiding secondary effects, usually triggered by impacting such central metabolites as RA. We propose to define this specific action of the RA on cDC using cutting edge technologies and state of art techniques both developed in the laboratory and brought by the candidate. These techniques will allow the investigation of the RA effect on specific intestinal cDC subsets at transcriptomic and phenotypic levels under homeostatic and pathologic states. The host laboratory will develop the professional skills of the candidate by reinforcing his individual competences, including laboratory techniques, writing, critical and innovative thinking, and communication abilities. Those will be further enhanced by the participation to many national and international collaborations enabled by Dr. Agace’s strong network. The high-quality infrastructure provided to the candidate and his complementary profile and techniques, acquired during his PhD, will ensure a solid project development and allow him to acquire all the abilities needed to become an efficient independent researcher.

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