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NanoPSYCH SIGNED

Neuropsychiatric disorders are a heterogeneous group of mental pathologies that demand prolonged and treatments that are frequently ineffective. Elucidating the cellular and molecular mechanisms under

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoPSYCH project word cloud

Explore the words cloud of the NanoPSYCH project. It provides you a very rough idea of what is the project "NanoPSYCH" about.

mode    search    disrupting    combining    map    synapses    nanoscopic    exploration    techniques    architecture    retention    classification    tackle    limitations    position    original    group    organization    elucidating    imaging    underlying    structures    heterogeneous    functional    dynamics    living    preferential    space    prolonged    nervous    integrity    neuropsychiatric    monitoring    inaccessible    diseases    ineffective    visualize    subject    molecular    cns    antibody    cellular    action    demand    nanoparticle    mental    nanotechnology    frequently    central    patients    extracellular    largely    unsolved    tissue    influence    examination    psychiatric    immune    brain    pathophysiology    therapeutic    biological    treatments    strategies    biotechnology    explore    illness    fueled    pathogenic    structural    accumulation    strategy    mediated    precise    subgroups    ecs    appropriate    accomplished    privileged    patient    pathologies    subgroup    tools    paramount    mechanisms    remained    recognition    disorders    regions    autoantibodies    decades    demonstrated   

Project "NanoPSYCH" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 196˙707.00

Map

 Project objective

Neuropsychiatric disorders are a heterogeneous group of mental pathologies that demand prolonged and treatments that are frequently ineffective. Elucidating the cellular and molecular mechanisms underlying these diseases is paramount for a precise classification of subgroups of patient and application of appropriate therapeutic strategies. The role of the immune system in the pathophysiology of neuropsychiatric disorders has been the subject of debate for many decades. However, recent recognition of antibody-mediated central nervous system (CNS) disorders has fueled the search for a subgroup of patients with an antibody-mediated psychiatric illness. CNS autoantibodies have demonstrated to be pathogenic by disrupting the functional or structural integrity of synapses and their study has become an exciting research topic. Several aspects about the mode of action of these pathogenic autoantibodies remain unsolved, such as their accumulation in specific brain regions. An important factor for this preferential retention could be the influence of brain extracellular space (ECS), a component of the brain that has remained largely inaccessible for exploration due to its complex organization and technical limitations for its examination in living tissue. Recent advances in Nanotechnology and Biotechnology have given rise to unique tools to tackle the study of complex biological systems, thus we are now in a privileged position to explore the architecture of the ECS and the dynamics of CNS autoantibodies into brain tissue. The aim of this project is to define how the dynamics of CNS autoantibodies is affected by the ECS architecture in specific brain regions. This goal will be accomplished by using an original strategy combining classical imaging approaches to map the distribution of CNS autoantibodies between different brain structures and nanoparticle monitoring techniques to visualize at the nanoscopic scale the dynamics of CNS autoantibodies and the ECS architecture.

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The information about "NANOPSYCH" are provided by the European Opendata Portal: CORDIS opendata.

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