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TOPOGRAPHYSENSING SIGNED

Effects of 3D topographies on mechanosensing in intestine epithelial architecture and dynamics

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TOPOGRAPHYSENSING project word cloud

Explore the words cloud of the TOPOGRAPHYSENSING project. It provides you a very rough idea of what is the project "TOPOGRAPHYSENSING" about.

locations    hypothesis    actin    epithelial    generating    epcam    shown    sophisticated    understand    organize    context    manner    regulation    interactions    segregated    modulation    geometric    mechanosensing    substrates    permeates    polarity    interacting    mechanotransduction    participates    precise    2d    actomyosin    scrutinize    cadherin    cellular    integral    cytoskeletal    cytoskeleton    primarily    contractility    biology    alpha    shows    exposed    epithelium    found    ladoux    molecular    platform    forms    groups    hypothesize    consists    cells    topographic    arrangement    vice    conform    mediated    functions    techniques    mechanisms    ankyrin    laboratory    modulated    maintenance    layered    form    until    topographical    defective    microfabrication    tissue    beta    contrast    multidisciplinary    sense    biophysics    cortical    adhesion    spatial    topographies    orderly    collective    network    spectrin    unknown    tension    disordered    versa    3d    cell    sites    dynamics    curved    cues    architecture    networks    observations    organization    monolayer    sensing    intestine    microenvironmental   

Project "TOPOGRAPHYSENSING" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 134˙600 € (68%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 134˙600.00

Map

 Project objective

Intestine epithelium consists of spatially segregated cells that organize into groups of various functions at different locations of the 3D curved epithelial monolayer. How geometric cues contribute to the maintenance of the sophisticated epithelial architecture and dynamics in 3D remains unknown until now. Recently, the Ladoux's laboratory has found that EpCAM-modulated cell contractility associated with the epithelial monolayer polarity, cytoskeletal arrangement, and cell-cell adhesion in 3D context. In contrast to 2D context, the EpCAM-defective tissue shows a loss of collective cellular spatial organization and forms a disordered multi-layered epithelium when exposed to substrates of 3D topographies. In addition, Ankyrin-G and α/β-spectrin network which participates in cortical tension modulation was identified as the main interacting partner with EpCAM in epithelial cells. These observations lead us to hypothesize that EpCAM allows the tissue to sense and conform to complex 3D topographies in an orderly manner. However, the molecular mechanisms and other related functions of EpCAM-mediated mechanotransduction remain unknown. As large scale mechanosensing has been shown to occur primarily through the actin cytoskeleton which permeates the tissue to form a network, we aim to understand the interactions between the EpCAM-mediated pathway and actin modulation and/or E-cadherin adhesion sites that may allow 3D topographical sensing. Our working hypothesis is that EpCAM forms an integral part of the cellular responses to topographic cues that has a more general role in controlling epithelial architecture and dynamics through the regulation of actomyosin networks, or vice versa. Here, we propose to scrutinize EpCAM-mediated mechanotransduction by generating a platform with precise control of geometric factors and microenvironmental cues using a range of multidisciplinary approaches including microfabrication, biophysics, and advanced molecular biology techniques.

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