Opendata, web and dolomites


Effects of 3D topographies on mechanosensing in intestine epithelial architecture and dynamics

Total Cost €


EC-Contrib. €






 TOPOGRAPHYSENSING project word cloud

Explore the words cloud of the TOPOGRAPHYSENSING project. It provides you a very rough idea of what is the project "TOPOGRAPHYSENSING" about.

regulation    contrast    microenvironmental    locations    techniques    spectrin    cells    mechanotransduction    beta    defective    epcam    ankyrin    tissue    participates    mechanosensing    versa    unknown    microfabrication    cortical    polarity    laboratory    precise    modulated    maintenance    arrangement    topographies    mechanisms    disordered    collective    cytoskeleton    spatial    networks    permeates    epithelium    mediated    groups    shows    biophysics    shown    organize    biology    alpha    context    platform    ladoux    cytoskeletal    cellular    actin    organization    geometric    cell    sites    adhesion    manner    vice    understand    observations    exposed    molecular    forms    3d    orderly    actomyosin    primarily    cadherin    sophisticated    functions    conform    generating    layered    contractility    tension    scrutinize    2d    interacting    hypothesis    integral    hypothesize    interactions    curved    topographical    sensing    modulation    multidisciplinary    network    found    dynamics    segregated    monolayer    substrates    epithelial    cues    until    topographic    sense    consists    architecture    intestine    form   

Project "TOPOGRAPHYSENSING" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 134˙600 € (68%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Intestine epithelium consists of spatially segregated cells that organize into groups of various functions at different locations of the 3D curved epithelial monolayer. How geometric cues contribute to the maintenance of the sophisticated epithelial architecture and dynamics in 3D remains unknown until now. Recently, the Ladoux's laboratory has found that EpCAM-modulated cell contractility associated with the epithelial monolayer polarity, cytoskeletal arrangement, and cell-cell adhesion in 3D context. In contrast to 2D context, the EpCAM-defective tissue shows a loss of collective cellular spatial organization and forms a disordered multi-layered epithelium when exposed to substrates of 3D topographies. In addition, Ankyrin-G and α/β-spectrin network which participates in cortical tension modulation was identified as the main interacting partner with EpCAM in epithelial cells. These observations lead us to hypothesize that EpCAM allows the tissue to sense and conform to complex 3D topographies in an orderly manner. However, the molecular mechanisms and other related functions of EpCAM-mediated mechanotransduction remain unknown. As large scale mechanosensing has been shown to occur primarily through the actin cytoskeleton which permeates the tissue to form a network, we aim to understand the interactions between the EpCAM-mediated pathway and actin modulation and/or E-cadherin adhesion sites that may allow 3D topographical sensing. Our working hypothesis is that EpCAM forms an integral part of the cellular responses to topographic cues that has a more general role in controlling epithelial architecture and dynamics through the regulation of actomyosin networks, or vice versa. Here, we propose to scrutinize EpCAM-mediated mechanotransduction by generating a platform with precise control of geometric factors and microenvironmental cues using a range of multidisciplinary approaches including microfabrication, biophysics, and advanced molecular biology techniques.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TOPOGRAPHYSENSING" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TOPOGRAPHYSENSING" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

EPIC (2019)

Evolution of Planktonic Gastropod Calcification

Read More  

lanloss (2020)

Landscapes of Loss: Mapping the Affective Experience of Deforestation Among Diverse Social Groups in the South American Chaco

Read More