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NCI-CAD SIGNED

Neutrophil - Chlamydia interactions at the crossroad of adaptation and defence

Total Cost €

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EC-Contrib. €

0

Partnership

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 NCI-CAD project word cloud

Explore the words cloud of the NCI-CAD project. It provides you a very rough idea of what is the project "NCI-CAD" about.

ubiquitin    itself    resolve    chronic    unexpectedly    rapid    rearm    subset    obligate    responsible    health    asymptomatic    cell    comprehensively    enormous    causes    polymorphonuclear    strategies    surprisingly    consequently    spread    offers    prime    made    innate    deubiquitinase    paralysis    broad    transmitted    damage    intriguing    pmn    nature    bacteria    laboratory    completely    inflammation    diseases    economic    subsequent    antibacterial    immune    cdu1    intracellular    unresponsive    lived    stis    survive    concomitant    sexually    severe    stimulated    cells    infections    unknown    converted    indicating    effector    bacterial    frequent    pathologies    protease    antibiotic    replication    sti    exposure    activation    preventing    themselves    chlamydia    host    trachomatis    resistant    stimuli    observation    ing    diagnosed    burden    chlamydial    unexpected    posses    patient    pmns    neutrophils    decades    mechanism    reprogramming    cpaf    unclear    explanation    defence    autonomous    secreted    tissue    incidences    infection   

Project "NCI-CAD" data sheet

The following table provides information about the project.

Coordinator
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG 

Organization address
address: SANDERRING 2
city: WUERZBURG
postcode: 97070
website: http://www.uni-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙499˙340 €
 EC max contribution 2˙499˙340 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) coordinator 2˙499˙340.00

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 Project objective

Incidences of sexually transmitted diseases (STI) have increased during the past decades with a concomitant rapid spread of antibiotic resistant bacteria. Chlamydia trachomatis is the most frequent cause of bacterial STIs. These infections often remain asymptomatic and are consequently not diagnosed and treated, resulting in the subsequent development of severe chronic pathologies and an enormous economic burden for health systems. The reason for the asymptomatic nature of chlamydial infection is currently unknown.

My laboratory made the intriguing observation that exposure of polymorphonuclear neutrophils (PMNs), a major subset of innate immune cells and cause of inflammation and tissue damage, to C. trachomatis causes PMNs to become unresponsive to a broad range of stimuli, including Chlamydia themselves. We identified a chlamydial secreted protease (CPAF) to be the bacterial effector responsible for preventing the activation of the non-stimulated PMNs. Chlamydia not only survive PMN exposure but can also surprisingly exploit the PMN itself as host cell for replication. Unexpectedly, the chlamydial secreted deubiquitinase Cdu1 is required for intracellular adaptation of Chlamydia, indicating that PMNs may posses antibacterial cell-autonomous defence strategies based on the host ubiquitin system.

It remains completely unclear how PMNs are converted to host cells for obligate intracellular bacteria. This proposal therefore aims to comprehensively investigate the mechanism of PMN reprogramming from a short-lived major immune effector cells to a host cell for Chlamydia replication and development. PMN paralysis offers an unexpected explanation for the asymptomatic nature of these infections. Furthermore, chlamydial factors involved in PMN reprogramming provide prime targets to rearm the patient’s immune response to effectively resolve Chlamydia infections.

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The information about "NCI-CAD" are provided by the European Opendata Portal: CORDIS opendata.

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