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CORKtheCAMBIA SIGNED

Thickening of plant organs by nested stem cells

Total Cost €

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EC-Contrib. €

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Partnership

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 CORKtheCAMBIA project word cloud

Explore the words cloud of the CORKtheCAMBIA project. It provides you a very rough idea of what is the project "CORKtheCAMBIA" about.

4th    organ    silico    tough    inducible    uncover    located    follow    cambium    specification    tracing    adjacent    regulating    corkthecambia    experimentation    thickening    thickness    plants    lineage    stems    specifies    ablation    lay    rational    lateral    xylem    lab    meristems    discover    reveal    regulatory    unpublished    origin    protective    awaited    timing    cells    2nd    combine    mechanism    expertise    layer    regeneration    cambia    matching    crop    3rd    tree    revealed    coordinate    utilize    cas9    growth    deduce    model    originates    dynamics    produces    vascular    phloem    crispr    radial    1st    remained    marker    genetics    mechanistically    orchestrated    molecular    organs    experiments    tightly    cell    co    regulation    specifying    cork    underlying    manipulation    mechanisms    regulated    perfect    regulate    foundation    wood    combining    nested    unknown    stem    unexpectedly    trees    stemming    intertwined    plant    meristem    mutant    forms   

Project "CORKtheCAMBIA" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙999˙752 €
 EC max contribution 1˙999˙752 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 1˙999˙752.00

Map

 Project objective

Growth originates from meristems, where stem cells are located. Lateral meristems, which provide thickness to tree stems and other plant organs, include vascular cambium (produces xylem [wood] and phloem); and cork cambium (forms cork, a tough protective layer). We recently identified the molecular mechanism that specifies stem cells of vascular cambium. Unexpectedly, this same set of experiments revealed also novel aspects of the regulation of cork cambium, a meristem whose development has remained unknown. CORKtheCAMBIA aims to identify the stem cells of cork cambium and reveal how they mechanistically regulate plant organ thickening. Thus, stemming from these novel unpublished findings and my matching expertise on plant stem cells and lateral growth, the timing is perfect to discover the molecular mechanism underlying specification of stem cells of cork cambium. To identify the origin of stem cells of cork cambium, 1st-we will combine lineage tracing with a detailed molecular marker analysis. To deduce the cell dynamics of cork cambium, 2nd-we will follow regeneration of the stem cells after ablation of this meristem. To discover the molecular factors regulating the stem cell specification of cork cambium, 3rd-we will utilize molecular genetics and a novel method (inducible CRISPR/Cas9 mutant targeting) being developed in my lab. Since the lateral growth is orchestrated by two adjacent, nested meristems, cork and vascular cambia, the growth process must be tightly co-regulated. Thus, 4th-an in silico model of the intertwined growth process will be generated. By combining modelling with experimentation, we will uncover mechanistically how cork and vascular cambium coordinate lateral growth.

CORKtheCAMBIA will thus provide long-awaited insight into the regulatory mechanisms specifying the stem cells of lateral meristem as whole, lay the foundation for studies on radial thickening and facilitate rational manipulation of lateral meristems of crop plants and trees.

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The information about "CORKTHECAMBIA" are provided by the European Opendata Portal: CORDIS opendata.

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