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CORKtheCAMBIA SIGNED

Thickening of plant organs by nested stem cells

Total Cost €

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EC-Contrib. €

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Partnership

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 CORKtheCAMBIA project word cloud

Explore the words cloud of the CORKtheCAMBIA project. It provides you a very rough idea of what is the project "CORKtheCAMBIA" about.

regulating    discover    stemming    specifying    expertise    inducible    mechanisms    underlying    thickness    intertwined    protective    experiments    lab    produces    3rd    silico    perfect    specifies    tracing    manipulation    marker    forms    lay    revealed    combine    rational    uncover    cas9    vascular    2nd    meristems    crop    originates    regulated    regulation    experimentation    co    timing    orchestrated    wood    cell    corkthecambia    origin    stem    awaited    deduce    stems    specification    utilize    thickening    growth    mutant    adjacent    genetics    cork    trees    radial    cells    foundation    mechanistically    plants    unpublished    molecular    follow    model    tough    lateral    tightly    coordinate    reveal    combining    cambia    layer    tree    dynamics    phloem    regulatory    crispr    located    lineage    4th    matching    plant    organ    regulate    ablation    mechanism    cambium    unknown    organs    nested    regeneration    1st    remained    unexpectedly    xylem    meristem   

Project "CORKtheCAMBIA" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙999˙752 €
 EC max contribution 1˙999˙752 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 1˙999˙752.00

Map

 Project objective

Growth originates from meristems, where stem cells are located. Lateral meristems, which provide thickness to tree stems and other plant organs, include vascular cambium (produces xylem [wood] and phloem); and cork cambium (forms cork, a tough protective layer). We recently identified the molecular mechanism that specifies stem cells of vascular cambium. Unexpectedly, this same set of experiments revealed also novel aspects of the regulation of cork cambium, a meristem whose development has remained unknown. CORKtheCAMBIA aims to identify the stem cells of cork cambium and reveal how they mechanistically regulate plant organ thickening. Thus, stemming from these novel unpublished findings and my matching expertise on plant stem cells and lateral growth, the timing is perfect to discover the molecular mechanism underlying specification of stem cells of cork cambium. To identify the origin of stem cells of cork cambium, 1st-we will combine lineage tracing with a detailed molecular marker analysis. To deduce the cell dynamics of cork cambium, 2nd-we will follow regeneration of the stem cells after ablation of this meristem. To discover the molecular factors regulating the stem cell specification of cork cambium, 3rd-we will utilize molecular genetics and a novel method (inducible CRISPR/Cas9 mutant targeting) being developed in my lab. Since the lateral growth is orchestrated by two adjacent, nested meristems, cork and vascular cambia, the growth process must be tightly co-regulated. Thus, 4th-an in silico model of the intertwined growth process will be generated. By combining modelling with experimentation, we will uncover mechanistically how cork and vascular cambium coordinate lateral growth.

CORKtheCAMBIA will thus provide long-awaited insight into the regulatory mechanisms specifying the stem cells of lateral meristem as whole, lay the foundation for studies on radial thickening and facilitate rational manipulation of lateral meristems of crop plants and trees.

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The information about "CORKTHECAMBIA" are provided by the European Opendata Portal: CORDIS opendata.

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