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CORKtheCAMBIA SIGNED

Thickening of plant organs by nested stem cells

Total Cost €

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EC-Contrib. €

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Partnership

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 CORKtheCAMBIA project word cloud

Explore the words cloud of the CORKtheCAMBIA project. It provides you a very rough idea of what is the project "CORKtheCAMBIA" about.

underlying    lab    xylem    utilize    4th    originates    timing    regulating    origin    wood    regulatory    intertwined    3rd    stems    foundation    combining    mutant    uncover    cambium    lay    mechanism    regulation    crop    adjacent    lateral    protective    experiments    revealed    plant    regulated    molecular    stemming    stem    corkthecambia    tracing    inducible    layer    organ    orchestrated    crispr    co    experimentation    phloem    genetics    cas9    trees    forms    specifying    cell    tree    marker    cambia    cells    perfect    thickness    coordinate    nested    growth    plants    mechanisms    2nd    unpublished    matching    thickening    silico    radial    meristem    expertise    unknown    unexpectedly    specifies    follow    organs    rational    manipulation    reveal    deduce    mechanistically    1st    vascular    ablation    meristems    awaited    regulate    located    tough    cork    tightly    lineage    regeneration    model    dynamics    combine    produces    discover    specification    remained   

Project "CORKtheCAMBIA" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙999˙752 €
 EC max contribution 1˙999˙752 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 1˙999˙752.00

Map

 Project objective

Growth originates from meristems, where stem cells are located. Lateral meristems, which provide thickness to tree stems and other plant organs, include vascular cambium (produces xylem [wood] and phloem); and cork cambium (forms cork, a tough protective layer). We recently identified the molecular mechanism that specifies stem cells of vascular cambium. Unexpectedly, this same set of experiments revealed also novel aspects of the regulation of cork cambium, a meristem whose development has remained unknown. CORKtheCAMBIA aims to identify the stem cells of cork cambium and reveal how they mechanistically regulate plant organ thickening. Thus, stemming from these novel unpublished findings and my matching expertise on plant stem cells and lateral growth, the timing is perfect to discover the molecular mechanism underlying specification of stem cells of cork cambium. To identify the origin of stem cells of cork cambium, 1st-we will combine lineage tracing with a detailed molecular marker analysis. To deduce the cell dynamics of cork cambium, 2nd-we will follow regeneration of the stem cells after ablation of this meristem. To discover the molecular factors regulating the stem cell specification of cork cambium, 3rd-we will utilize molecular genetics and a novel method (inducible CRISPR/Cas9 mutant targeting) being developed in my lab. Since the lateral growth is orchestrated by two adjacent, nested meristems, cork and vascular cambia, the growth process must be tightly co-regulated. Thus, 4th-an in silico model of the intertwined growth process will be generated. By combining modelling with experimentation, we will uncover mechanistically how cork and vascular cambium coordinate lateral growth.

CORKtheCAMBIA will thus provide long-awaited insight into the regulatory mechanisms specifying the stem cells of lateral meristem as whole, lay the foundation for studies on radial thickening and facilitate rational manipulation of lateral meristems of crop plants and trees.

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The information about "CORKTHECAMBIA" are provided by the European Opendata Portal: CORDIS opendata.

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